Dumb Question about rising PSA after initial RT.

[Researcher50]

If you still have a prostate after RT treatment 7 years ago ( NO ADT), could a slowly rising PSA just be 'natural' as you age? Have always been curious, as when initial biopsy was ordered, the doctor said, "if you were a few months older (70), your PSA level would not have prompted further investigation".

Reason for asking is with a recent clear PSMA-PET, do we say 'thank you, Cancer gods, and ignore the rising PSA, or get more aggressive?

So act like a Canadian or an American? LOL! (BTW, loved that post--sent to nephew in Ontario)

[KocoPr]

No dumb questions here.

What are your psa numbers?

[Researcher50 in reply to KocoPr]

See Bio. Things were fairly stable, then a jump with consecutive rises, but not official BCR. People in this group suggested asking for PSMA-PET, which we did and it was clear. Last recent PSA was down slightly, but the results from this lab are ALWAYS lower. (Before someone comments about not using the same lab, we split our year between north and south, and Quest is not available in both places. Also the times of year of testing are different. )

[Tall_Allen]

Biochemical recurrence is nadir+2. No need to investigate further until that happens, or at least nadir+1 and consistently rising.

[Researcher50 in reply to Tall_Allen]

OK, I will keep up our offerings to the Cancer gods and use the Canadian approach for the time being. I also plan to continue monitoring this group for the outstanding information and insight on treating PCa. On the initial go-round was woefully ill-informed and don't want a repeat if needed. Besides, have become quite attached to you guys over the years!😊

[jfoesq in reply to Tall_Allen]

Tall-Allen

I a familiar with the 2+ standard you mentioned but am not familiar with the +1 and consistent rising. How does one "investigate" a +1 with consistent rising? I thought 2.0 amd above was needed for a PSMA scan to be useful. THX

[Tall_Allen in reply to jfoesq]

PSMA PET scans are very sensitive at PSAs of 0.5 upon recurrence. One can also get an mpMRI.

[jfoesq in reply to Tall_Allen]

Thank you!

[jfoesq in reply to Tall_Allen]

Is the mpMRI at a PSA of .5 or above only effective if you haven't had your prostate removed?

[Tall_Allen in reply to jfoesq]

PSMA PET, not mpMRI.

0.5 is post-prostatectomy.

[jfoesq in reply to Tall_Allen]

Thx, again

[j-o-h-n]

We limit one dumb question per customer.....However, if you've ever gotten down on one knee and asked someone if they would marry you?.....Then you're already over the limit.

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 01/17/2024 8:08 PM EST

[skiingfiend in reply to j-o-h-n]

Step 1. Get down on one knee

Step 2. Fall down on two

youtube.com/watch?v=DCjE-29...(Not working as expected?)

[BluesmanNick in reply to skiingfiend]

Oh boy! The man. 😉👍👌

[j-o-h-n]

Step 3. Prostrate

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 01/18/2024 10:55 AM EST