Rising PSA

[John347]

Hi all,I had RT about 2 years ago and have been having 3 monthly Lupron jabs. My PSA has been rising steadily from a low of 0.02 ug/l (May, 2024) to 0.04 ug/l (August, 2024) The result of my blood test today is 0.09 ug/l (Nov, 2024).

My PSA seems to be doubling every 3 months. Is this cause for concern? Or, are the readings normal considering my prostate is still intact? Or, is the Lupron starting to fail?

Thanks for any advice.

[Justfor_]

They will tell you that BCR post RT is nadir +2. So, you will have to wait until 2.02 which is absolutely nonsense as this 0.02 was achieved under ADT. IMO your RT has failed to the degree that ADT isn't enough to mask it up. Only way to know more than wait-and-see would be a PSMA PET/CT. Sorry if I brought you bad news.

[Mgtd]

Just to confirm are you still getting Lupron shots or have you stopped getting them?

[John347 in reply to Mgtd]

The Lupron shots are still ongoing. Next shot is next week after consultation with MO.

[Mgtd in reply to John347]

Thanks for the reply. I am almost in the identical situation except I am off the Lupron and my T has returned to my normal range of around 700. My MO told me as my T rises I can expect the PSA to increase also. However in your case your T should still be low in the castration range.

Have you had your T tested recently to see if Lupron is working as advertised?

[John347 in reply to Mgtd]

Thanks for sharing Mgtd. I have not tested my T level recently but should still be low as evidenced by the usual side effects of low T.

[Fiddler2004]

Hi John, has your MO suggested adding another med to the Lupron injections? (i.e. Zytiga w/ Prednisone or Xtandi? Could help augment the Lupron. Are your Lupron injections every 3 months or monthly every month? Have you missed any injections? You're still in a good place IMHO but I wouldn't wait for it to climb too high...