Moved from Abi to Nubeqa and saw a PSA increase

[Steel67]

I recently switched from Abiraterone/Prednisone to Nubeqa because of the high blood pressure that I had with Abi requiring additional BP meds. I was previously .058 a month ago when I switched and .109 today, almost double in a month. Any one with experience with this switch?

[MateoBeach]

That is surprising to me and I cannot think of a reason unless you hada previous failure on aa "lutamide" ARSI. Would repeat the test to confirm the ressults.

[DennisCA]

I did the same several months ago and did not have that problem. I also took a vacation from Lupron about 6 months ago (but still take Nubeqa) and, so far, my PSA has stayed <.1, which is what the MO wants. I assume that will change at some point. MO said that if cancer pops up we will try radiation, or, if we can't, it is back on Lupron and/or other drugs.

I call it better (?) living through chemistry.

[rick8637]

This is not the first time i have heard this but it could be just by chance. One month ago i quit taking xtandi and started on Nubeqa. I have been taking Xtandi for 11 months and have had continuous drops in psa every 3 months by about a point. Last was 1.4 sept 10. I switched to nubeqa nov 1 and a month later tested 1.4 again. I was hoping for even a small drop. I hope to have a better # in 3 months or i might consider going back to xtandi. So far the SEs are easier to take so it is a tossup!

[Jbooml]

I quit Abiraterone last spring after having many wierd cardio issues after 4 unbroken years use. Could have been all the spike protein spillover circulating in vaccinated population contributing? Anyway I’m better now with just 4 month Eligard shots. I’ve had to keep up on prednisone every other day as my hip joints were so weak after I tapered off. I’m one of the lucky super responders to ADT so take it for what that’s worth. We’re all very different having somatic (epi)genetic etiologies that don’t necessarily transpose with other histories. Hope this helps.