Anyone here? switched to Nubeqa from Xtandi

[God_Loves_Me]

I wanted to know if anyone here in this group tried Xtandi which stopped responding after few months and switched to Nubeqa and it worked and showed success.

[tango65]

Great.!!

[vintage42]

I see you don't need ADT because of the orchiectomy. You went from Zytiga to Xtandi after only 2 months, and after 4 months you want Nubeqa. Is that because the first two did not lower the PSA? I am told that FDA does not approve Nubeqa added to ADT without Taxotere. I wonder how the orchiectomy will be considered.

[God_Loves_Me in reply to vintage42]

You can have Nubeqa without Taxotere. I have confirmations from MO.

[Teacherdude72 in reply to vintage42]

If the FDA does as you say then my 33 months of Lupron/Nubeqa was a violation. Neither of my MO, one was reassigned to skin cancers, mentioned that nor my RO.

[vintage42 in reply to vintage42]

I will take it up with my urologist next week. A few weeks ago his nurse stormed out of the room when I questioned the Erleada he prescribed, then brought me the Nubeqa exception application to sign, and said I would have to discuss the meds with the urologist.

[God_Loves_Me]

Ya first two did not lower or control the PSA.

[Hidden]

I switched, almost no side effects. I follow the STEP-UP trial, works very well.

[God_Loves_Me in reply to Hidden]

What' was primary reason to switch from Xtandi to Nubeqa ?

[FigureGround]

I switched from Xtandi (enzalutamide) to Nubeqa (darolutamide), which I take along with Orgovyx. Not sure I can really tell the difference, but not a lot of complaints either.

[God_Loves_Me in reply to FigureGround]

What' was primary reason to switch from Xtandi to Nubeqa ?

[FigureGround in reply to God_Loves_Me]

If I remember right (working through brain fog...), I think I believed from reading that darolutamide had less side effects than enzalutamide, but I don't know if that's true. Also, Astellas removed me from their Patient Assistance Program.

[Hidden]

Half time, Daro has 20

Hours, Enza almost a week. I want to create a shock for the cancer cells.

[j-o-h-n]

As I posted before..... My doc switched me off Bicalutamide (a/k/a Casodex) to Nubeqa.....and so far it's working.

Good Luck, Good Health and Good Humor.

j-o-h-n

[Nubeqa22]

My husband had been on Xtandi for several months when he experienced a mini-stroke. Sitting in his chair and didn’t know his dog’s name or where he was. Fortunately, no lasting obvious deficits, but that was the impetus for switching him to Nubeqa this past couple of years. So far no problems and it’s been keeping that @$#% disease at bay.

[MateoBeach]

Darolutamide has many fewer vulnerabilities to mutations that lead to failure. Aside from the better SE profile, it may work longer and better than enzalutamide or apalutamide. Worth going for the "exceptions application" if you don't actually need docetaxel chemo presently.

pubmed.ncbi.nlm.nih.gov/342...

[Joeym1040]

I failed Nubequa after 4 months and asked my MO if i could try Xytiga or Xtandi and he said no. Fail one, fail all. Is he correct?

[God_Loves_Me in reply to Joeym1040]

I don’t know but same thing my dr told me

[Joeym1040 in reply to God_Loves_Me]

Let's see what TA has to say.

[garyjp9 in reply to Joeym1040]

I know several men who had lots of problems with Xtandi SEs, especially fatigue and brain fog, and were able to switch to Nubeqa, which they find causes them much fewer problems.

[God_Loves_Me]

Tall_Allen any inputs on Joeym1040 question ?