Anyone here? switched to Nubeqa from Xtandi

[God_Loves_Me]

I wanted to know if anyone here in this group tried Xtandi which stopped responding after few months and switched to Nubeqa and it worked and showed success.

[tango65]

Great.!!

[vintage42]

I see you don't need ADT because of the orchiectomy. You went from Zytiga to Xtandi after only 2 months, and after 4 months you want Nubeqa. Is that because the first two did not lower the PSA? I am told that FDA does not approve Nubeqa added to ADT without Taxotere. I wonder how the orchiectomy will be considered.

[God_Loves_Me in reply to vintage42]

You can have Nubeqa without Taxotere. I have confirmations from MO.

[Teacherdude72 in reply to vintage42]

If the FDA does as you say then my 33 months of Lupron/Nubeqa was a violation. Neither of my MO, one was reassigned to skin cancers, mentioned that nor my RO.

[vintage42 in reply to vintage42]

I will take it up with my urologist next week. A few weeks ago his nurse stormed out of the room when I questioned the Erleada he prescribed, then brought me the Nubeqa exception application to sign, and said I would have to discuss the meds with the urologist.

[God_Loves_Me]

Ya first two did not lower or control the PSA.

[Hidden]

I switched, almost no side effects. I follow the STEP-UP trial, works very well.

[God_Loves_Me in reply to Hidden]

What' was primary reason to switch from Xtandi to Nubeqa ?

[FigureGround]

I switched from Xtandi (enzalutamide) to Nubeqa (darolutamide), which I take along with Orgovyx. Not sure I can really tell the difference, but not a lot of complaints either.

[God_Loves_Me in reply to FigureGround]

What' was primary reason to switch from Xtandi to Nubeqa ?

[FigureGround in reply to God_Loves_Me]

If I remember right (working through brain fog...), I think I believed from reading that darolutamide had less side effects than enzalutamide, but I don't know if that's true. Also, Astellas removed me from their Patient Assistance Program.

[Hidden]

Half time, Daro has 20

Hours, Enza almost a week. I want to create a shock for the cancer cells.

[GeorgeGlass in reply to Hidden]

What does this mean?

[j-o-h-n]

As I posted before..... My doc switched me off Bicalutamide (a/k/a Casodex) to Nubeqa.....and so far it's working.

Good Luck, Good Health and Good Humor.

j-o-h-n

[Nubeqa22]

My husband had been on Xtandi for several months when he experienced a mini-stroke. Sitting in his chair and didn’t know his dog’s name or where he was. Fortunately, no lasting obvious deficits, but that was the impetus for switching him to Nubeqa this past couple of years. So far no problems and it’s been keeping that @$#% disease at bay.

[GeorgeGlass in reply to Nubeqa22]

Is it still working?

[Nubeqa22 in reply to GeorgeGlass]

Yes and no, it did for about 4 years— recently PSA went up a bit, which triggered a PET scan. He now has a few bone mets that have freaked us out. Doc has kept him on the Nubeqa for now along with the every 12 weeks injection. If things progress, they are talking about going to chemo/ trials. The takeaway is that he was diagnosed in 2013 at age 67–now 78. So we managed to get that much time …so far.

[GeorgeGlass in reply to Nubeqa22]

Well, i wish you the best going forward. This is the way it odd for most of us on this site. The bones would probably lead to a longer life but with alot of pain. I’m probably going to die because the cancer has found its way to an artery that’s connected to the aorta, which will lead to blood clots in the brain etc. Nobody likes to have these kind of discussions on this site, but they are very sad realities. We just have to try the trials, and probably try them before we get too weak. 78 years old is good. I’m only 59, and been dealing with this for almost ten years. You also need to consider immunology bs pluvicto etc.

What injections are you referring to, lupron?

[Nubeqa22 in reply to GeorgeGlass]

59 is not enough; hoping you get more — with some quality time. so sorry. Husband’s father died of it . We have a son and 6 grandsons between our 3 kids. Stinks to know what they are all likely genetically predestined for.

The injection every 12 weeks is a slow release “capsule” that at present I can’t remember the drug name. 😵‍💫

[MateoBeach]

Darolutamide has many fewer vulnerabilities to mutations that lead to failure. Aside from the better SE profile, it may work longer and better than enzalutamide or apalutamide. Worth going for the "exceptions application" if you don't actually need docetaxel chemo presently.

pubmed.ncbi.nlm.nih.gov/342...

[Joeym1040]

I failed Nubequa after 4 months and asked my MO if i could try Xytiga or Xtandi and he said no. Fail one, fail all. Is he correct?

[God_Loves_Me in reply to Joeym1040]

I don’t know but same thing my dr told me

[Joeym1040 in reply to God_Loves_Me]

Let's see what TA has to say.

[garyjp9 in reply to Joeym1040]

I know several men who had lots of problems with Xtandi SEs, especially fatigue and brain fog, and were able to switch to Nubeqa, which they find causes them much fewer problems.

[God_Loves_Me]

Tall_Allen any inputs on Joeym1040 question ?