Xgeva side effects?????

[MydogisTed]

I started ADT a little over a year ago. I'm on Trelstar and my PSA is < 0.04. In March of this year I started taking Erleada. The side effects from both drugs have been minimal, some hot flashes and fatigue. Two months ago my doctor started me on Xgeva. The first dose I felt no ill effects, but the next dose kicked my butt. The day after the second injection I felt like I had the flu, body aches, chills, and my heart rate climbed to over 100 bpm. Luckily, I felt better the following day. Yesterday I go to my general practioner to have routine blood work done, and I find the my cholesterol, which is normally around 120 has climbed to 205, and my triglycerides have practically doubled. I'm on cholesterol meds, and after some investigation, I find that there is a moderate(??) drug interaction between the the Xgeva and my cholesterol meds. I'm wondering if it is going to be worth continuing the Xgeva. Any thoughts or comments?

[rsgdmd]

What was the interaction you found between Xgeva and statins - I couldn't find any. I'm on simvastatin & have had no SE (so far) with Xgeva,

[MydogisTed in reply to rsgdmd]

I'm on Ezetimibe/Simvastatin for cholesterol. Go to Drugs.com/drug_interactions and you can compare the two drugs.

[rsgdmd in reply to MydogisTed]

Seems like the interaction is between the 2 cholesterol meds.

[MydogisTed in reply to rsgdmd]

yes, after I looked at it again, that’s how it appears.

[epfj3333]

If your PSA was undetectable,

If your PSA was undetectable, why did you start switching drugs?

[MydogisTed in reply to epfj3333]

That's a good question that I will discuss with my urologist/oncologist on my next visit.

[SteveTheJ]

Those side effects are similar to what I've heard about. Does a bone density scan indicate any issues and if not, why are you taking Xgeva at all?

[MydogisTed in reply to SteveTheJ]

I had a bone scan done in 2022 and I had 3 lesions in my spine and pelvis. From what I read the Xgeva is standard treatment for prostate cancer that has metastasized to the bone.

[SteveTheJ in reply to MydogisTed]

I have bone metastases as well but never had an infusion like that. IMHO, get a bone density scan to determine if you even need it.

[MydogisTed in reply to SteveTheJ]

Thanks, that's a good point. I will discuss with doctor on my next visit.

[j-o-h-n]

MydogisDead...............There's plenty of people who think my ex-wife killed him and ate him. It's still under investigation.....

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 07/06/2023 6:09 PM DST

[Mormon1]

I am 72. In great health except for metastatic prostate cancer. Been on xgeva for almost 4 years. The shot hurts. I adk them to spray numbing spray befor the injection. I get 3 months at a time. I have had no problems. No broken bones. The cancer had attacked my thoracic spine. So I am kind of stuck. Check with your vancer doc about the adverse reactions. Try to hang in there my friend. God bless. Not easy getting old.

Pops old store

[MydogisTed in reply to Mormon1]

I’m glad that the Xgeva has worked well for you. Good luck!!!

[j-o-h-n in reply to Mormon1]

Geez I can still see Pop's thumb on the weighing scale..... Can't get ride of bad habits.....

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 07/07/2023 7:31 PM DST