I have been on Xtandi ( on a trial) for the last 6 months because of spread to my bones. I am having major cognitive difficulties so the dose was reduced from 4 pills a day to 3. (120mg.) My PSA was 25 when I started on the Xtandi 6 months ago and it has been dropping VERY slowly- only as low as 15. This month my PSA went up to 18 though the scans are stable so far. My doctor doesn't seem to be concerned but I am. Has anyone heard of this happening? I am also considering switching to Zytiga as it doesn't seem that the side effects (particularly cognitive) are as bad. But my doctor said that if the Xtandi fails, the Zytiga will not work.
Would love some opinions.