Hi, I'm new here. Was diagnosed with PCa in 2015, Stage IV, PSA 22.2 when diagnosed mets to brain, spine and hips. I don't have a Gleason since they have never done a prostate biopsy. I've had an Orchidectomy, Radiation to my brain and then had 6 rounds of Taxotere and then again radiation to my spine and currently my hips. Finish this next week and then they want me to go onto Xtandi. My fatigue is at an all time low, hardly able to get up to go to the bathroom, is this Xtandi going to knock me down even more??? From what I've read fatigue is the main side effect, but since I'm already so fatigued, hoping it won't get any worse......experiences out there??