Xofigo or Radium Lately?

[Steve77755]

Considering this after a successful six sessions of LU-177 (Pluvicto), but now PSA is rising quickly. Thanks.

[GP24]

If Pluvicto worked well for you, additional cycles will usually work well too. I would use Xtandi as maintenance therapy during and after Pluvicto. Get two cycles and then check with a PSMA PET/CT how well it worked.

[Hidden in reply to GP24]

my guy is starting Pluvicto March 30, But his doctor said he has to come off his Xtandi during the treatment. Actually said he has to be off of it for 30 days before he starts. Are there doctors that allow patients to stay on other cancer meds during treatment?

[GP24 in reply to Hidden]

This advice is wrong, do not stop Xtandi! Xtandi increases the PSMA expression and makes Pluvicto more effective:

Xtandi doubles overall survival in combination mit Pluvicto.

[Hidden in reply to GP24]

thank you for this. I’ll research it and speak to his doctors.

[GP24 in reply to Hidden]

To help with your research, here is a report about this:

mdpi.com/2072-6694/14/11/2691

[j-o-h-n in reply to GP24]

You're a saint..............

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 02/13/2023 8:11 PM EST

[Seasid in reply to j-o-h-n]

Yes

[Seasid in reply to GP24]

Correct

[Hidden in reply to Hidden]

Listen to his doctor. If course you can ask why he recommends stopping or adding what he does, but nobody knows your husband better than his doctor.

[Hidden in reply to Hidden]

I wish I could say that is true. But my mother died after a routine heart catheterization. That’s when I learned that you have to watch everything like a hawk. I had an extra 2 1/2 years with my father because I didn’t trust everything the doctors did and double checked everything. The first Doctor that diagnosed him said he would not have chemo because he was too far along. When I pointed out a study from the University of Virginia that showed that chemo extended the life significantly she backpedaled and agreed. Of course I got him away from her. But doctors are not all knowing. And if you completely trust them you’re making a mistake. I learned that the hard way. Sorry if that sounds cynical. But it has been my experience.

[Tall_Allen]

Good idea! (as long as your bloodwork is sufficient)