Chemo showing signs of not working anymore, will soon be switching to Xofigo Radium 223, starting to scrape the bottom of the barrel as far as treatments for 4th stage metastatic prostate cancer treatment, im kind of worried and i am scared that the side effects may be bad, i dont know but will find out, i just dont want to die a horrible painful death.
jack
Mrjack, wow, you’ve been fighting so hard for some time. I commend you in this battle. A cruel disease. Wish I could help in some way... any advice to us that are trailing you or just starting out. ? I will suggest any form of canabis to maybe not cure but possibly to help many of those side effects..
yes, I know what you mean, I'm looking for an affordable vape device, smoking is hard on the throat and lungs. need something smoother. try to enjoy life and laugh a little.
thanks
jack
Difficult when brutalized in pain or suffering. I am not currently suffering too much .Thank god !. Not in denial as to what the future may hold. Basically live for today.. Vaping in general is for getting high primarily. I like it. They discard most of the cbds to consentrate on the Thc high. Taking pure cbd alone is beneficial . For health issues you need both. I’d suggest edibles and edible oil is the best.. I would try almost anything in hope to relief symptoms. If you find that you like the effects of Thc it can enhance and improve your daily outlook. Food taste better , music sounds better, comedy is funnier, it basically can break up monatomy if you are experiencing it. It’s a crutch , with benifits.... not for everybody but it helps me.
Mr. Jack: I don’t know what state your in, but you got to try some CBD combined with some THC (THC causes aptosis to cancer cells).You’ve got to find a dispenser you trust, and spell out your needs to them. I’ve also made my own cancer formula using a flower tower I purchased out of Florida($500.) ; and basically it’s an essential oil machine. You take the cannibus you purchase or grow, ground it up like coffee, and run it through the tower. Instructions are online and you can google the flower tower for purchase. I am going to start this up again. I would take the oil out of the syringe I captured it in, and put same in clear vitamin caps at measured doses. It’s a little messy but works. The dispenser folks can guide you on varieties good for pain and aptosis. No absolutes but it may help. I can’t smoke that stuff either. Once while making a batch I spilled the black residue on my wrist and hand and I got a little looped. The dermis us a great delivery system as well, though I wouldn’t advise same. Good luck
aptosis
What about Lu 177 PSMA treatment. There are some clinical trials going on.
The side effect profile of Xofigo is very favorable in most men. It increases quality of life by reducing metastatic burden and relieving bone pain. It also pairs very well with immunotherapies like Provenge. It doesn't seem to pair well with Zytiga. Xofigo and chemo are always more tolerable when used earlier in the course of the disease.
thank you
In regard to Mr Jack, I agree with Tall_Allen about Xofigo ie, radium 223, that it can have beneficial effect on bone mets. Cost in Australia is 6 infusions for usd $50,000, but getting Provenge treatment is much more expensive. And a man would need to have enough white cells to be able to be altered by Provenge so I am not sure if Provenge might work after a previous course of chemo.
I have big doubt that THC in cannabis has any effect on Pca and I think that's all wishful feeling. I grew my own cannabis from some wild Sativa plants which gave very low yield of cannabis oil. But it gave a beautiful high without any of the bad feelings of paranoia and anxiety that THC gives without a lot of CBD also present. I took nightly dose of only 2mg, a tiny amount of undiluted oil, more like a dark brown grease, nightly at 6pm for 8 months, and from 8pm to bedtime at midnight I was high as kite, and that made me think emotionally and become unable to be rational so I stayed home and did not drive or do any craft work. Sure I felt relaxed and calm, and happy. The days were all just fine and no sign of being high or impaired in any way. But for those 8 months, while continuing with ADT, there was not the slightest downward movement of my Psa, so I quit taking the oil. There was no sudden increase in Psa. There were no withdrawal symptoms and no addiction no paranoia, I just went
"back to normal" probably because my mind copes OK with general reality of both joys and troubles quite OK without ever needing any substances.
I also tried eating 30 apricot kernels a day for many months. These bitter almonds each have about 1mg amygdalin with cyanide within, which causes the bitter taste. The Pca cells are said to be killed when they let amygdalin molecule come in, but I saw no downward movement of Psa. In 1950s, there were clinics where up to 2cc or about 2 grams of amygdalin were infused into a vein daily. The trade name was Leatrile, and Leatrile clinics were outlawed by US authorities after it was found to be quack medicine that did not work. I read Leatrile clinics still operate in Mexico, and they claim 15% success with desperate patients with nothing to lose. But for me, amygdalin, like cannabis, had no effect on my Pca progress. UK report said more than 4 apricot kernels per day were toxic, but I felt not the slightest toxicity with 7 times the "toxic" level.
I just read a report elsewhere here where Ra223 plus abiraterone does not work too well. But the report did not say anything about cures, so Ra223 plus anything else just extends survival time and there would be a nasty end game when all treatments options come to an end. But the latest pain relief with Fentanyl implants probably stop the suffering. The Fentanyl is about 2,000 times more effective than heroin, and addictive, but I'd rather end my days as a medically supervised drug addict than try to just tough it out like an irrational hero.
I'm getting Lu177 now. After 2 infusions, Psa has moved from 25 to 17, and all soft tissue mets cannot now be seen in PsMa scan. Bone mets have declined a little, and no new bone mets are seen. I came to Lu177 earlier than most men who often come when Psa is 250, and bone met size is large.
I am 71, and fairly fit. Before No 2 infusion I cycled 960km in 3 weeks.
The second infusion made some temporary pain in 5 bone joints, but 4 have no pain now and only 1 hip has slight pain that made me feel uncertain about cycling, so I quit that for awhile, except for a 50km ride once a week to compare how my hip feels before, during, and after the ride.
But in last 5 weeks I have replaced 40metre long fence at my house, have re-laid a large area of paving bricks and although there was pain in hip before the work, during the work the pain vanished and its like going back to 1992 when I was still doing building work to earn a living. So far my docs think I am going OK and they like to see me arrive to talk to them dressed in lycra because they see a man who practices all the good ways of body health, unlike so many who never do exercise, have 4 other co-morbidities like diabetes, obesity, heart troubles. But I was lucky to have had a firm fair mind installed by Nature into my darn brain. Nature is not perfect, and you cannot have perfection in any system that is designed by Nature during millions of years of evolution all by trial and error. There does not seem to be any other way a man or a woman or any other living creature could have been created; I just cannot accept that a God said "Let there be Man" and he thought up all the DNA in an instant of creation. Old books like the Bible are a fantasy with grandiose ignorance of Nature. There may me a guide about morality, but nothing about the reality of Nature.
Nobody will die wise enough to know everything. I find I feel no need to know it all. Aging is inevitable, and one day I'll just have to un-exist. I'll enjoy the nurses until my end, and handle the future with the same lack of fear as I handled the past.
Hello Tall_Allen
I did in my lapptop a folder under yout name because your information is very valuable for me.
I did a blod test recently B-LPK
NPU-kod3.4 10e9/L ( 3.5-8.8
) its o.1 less than average ,by the way i did my psa its <0.1 i'm taking Bicalutamid 150 after my latest treatment of my lymp nodes april 2019,23 secessions my onkologist in Germanhy told me to stop bicatulamide on october this year.
I'm doing PSA test every 3 months.
Thanks for any answer
Regards from Sweden
George
Hi George - Sorry, I don't understand the terms: "B-LPK NPU-kod3.4 10e9/L" But your undetectable PSA is certainly a good sign.
Hello Tall_Allen
( B-LPK = LPK - leukocytes, white blood cells ) My test it was 3.4 and it should be between 3.5-8.8 its a borderline the differece is 0.1
should i be worry for that.
Thanks
Regards from sweden
George
Not unless you're starting chemo now.
Prayers sent your way MrJack that your mind and soul take a turn for the better. We're all in this together.
Ralph
thank you, I'm starting to realize the mind and soul part, I don't have a choice in having this disease, but I can choose how I react to it, so I hang on and make the best, try to laugh and do the best I can, I hate to be a burden to others. I'm ok now.
thank you
That sounds great, Mrjack. And next time, eat way less of that chocolate bar! I can't get them here in Florida (the legislature here make so many things so hard) but I can vape. I get oils and a vape stick that works wonderfully well. The stick was $75, and the oils were another $100. I did get a $75 discount for spending over $100 on my first visit which paid for the stick. I do NOT recommend the really cheap vaping devices if you can help it.
Good luck and God bless, Mrjack, and go easy on the chocolate!
Radium 223 instead of enzalutamide 
Timing of XGeva & Radium 223. 
Starting Xofigo RA 223
Radium 223
Radium-223 and [177Lu]Lu-PSMA
