Alk Phosphate going up after third Radium 223

[mdiaz76]

hello all.

Husband dx in 2017 with 489 PSA.

So far we’ve done Docetaxel, Xgeva, Zytiga. Currently on Xofigo (Ra 223) it knocked the Alk Ph way down then after the third treatment it went up a few points. Has this happened to anyone?

RO suggests doing 4th treatment then PSMA scan to see if there’s improvement.

Any suggestions feedback is helpful. Feeling a little anxious at the moment

[CAMPSOUPS]

Only went up a few points then I like the RO's plan.

When is the next Xofigo treatment and PSMA scan? If its only 2 or 3 weeks away so much the more I think you can relax.

[mdiaz76 in reply to CAMPSOUPS]

Nexf Xofigo is 12/16 then scan.

[MateoBeach]

Good plan.

[Wings-of-Eagles]

mdiaz76,

I have been on Zytiga for 8 years now, and the Alk Ph value is always watched closed on my labs every three months. The higher the value is an indication your bones may be getting weaker. These treatments are known to knock the PSA way down, not sure about the Alk Ph. I always thought they were likely to increase the Alk Ph value somewhat. Fortunately for me long term, the values are consistently below 100. I do not know the effects of Xogifo, but likely that may be the cause. A few points is probably normal. Trust your Doctors's plan ,as we here are all laymen.

Wings