How to get cell counts back to normal after Radium 223 (Xofigo) first dose?

[Luucy]

Since my Dad had his first dose of Radium 223 (Xofigo), a few months ago now, his cell counts; Neutrophils, white blood cells, Heamoglobin and platelets have decreased.

There was mention of a blood transfusion but I don't think it is necessary yet.

He obviously can't continue with his treatment until these levels are down, can anyone recommend any supplements or advice on how to bring these levels back to a healthy level please? We are in the UK.

He is feeling very tired with little appetite, and has swollen ankles now too.

Thanks

[Tall_Allen]

Unfortunately, the cancer itself has those effects too. When bone marrow gets damaged by chemo or radiation, you have to wait for its function to recover. Medicines that stimulate one factor or another (like erythropoietin) may strain his existing resources. If the cancer has damaged his bone marrow, it is not a good idea to continue radiation of it - it may destroy what he has left. A bone scan may tell you the degree of bone marrow infiltration.

[vivamais7 in reply to Tall_Allen]

Try papaya leaf tea or papaya leaf extract. Google "papaya for platelet count". Also, look at Febendazole. I have been on Xofigo and Febendazole and after 4 shots I am going to stop Xofigo and go on with Febendazole and nothing more as my PSA count is getting normal.

[Tall_Allen in reply to vivamais7]

All the papaya in the world won't restore bone marrow function. PSA is not cancer.

[vivamais7 in reply to Tall_Allen]

Your opinion. I have 24 years experience fighting prostate cancer and I only suggest what has been working for me. Back 17+ years I have not accepted RP ((I believe the most stupid thing doctors want us to accept) and liveded a wonderful life on Dr. Rath's therapy till the day an urologist made me reduce Vitamin C from 5 to 2 grams a day. Because of this reduction my PC turned metastatic and then I have been submitted to 30 shots of Radiotherapy and as a consequence I have got problems with my platelets and YES Papaya Tea as helped. Also I have used Cannabis oil (RSO) and YES for almost an year I have been cancer free while I have been able to get the real RSO (most sources of this medicine are scamers).

For the last 4+ years I have returned to Allopathic Medicine: Radio Surgery (a failure) and for the last 4 months on Xofigo and YES on Fenbendazole.

PSA is not Cancer but those who have PC have abnormal levels of PSA as you probably know. Meanwhile here goes my last PSA counts: before Xofigo PSA=128; after 1st. Xofigo PSA=254; after 2nd. Xofigo and Fenbendazole PSA=246 (-8); after 3rd. Xofigo and Fenbendazole PSA=190 (-56). The analisys for the last Xofigo shot will take place on 5/18. For the last 18 months I have been out of hormone therapy. This makes me believe that Fenbendazole (4 days on 3 days off) works.

How successful have you been with YOUR cancer?

[Tall_Allen in reply to vivamais7]

I am cured. But that is irrelevant. So are your beliefs about cause/effect of your attempts at therapies, like oral Vitamin C. It turned metastatic because you didn't curatively treat it when you had the opportunity.

The OP didn't just have problems with his platelets, he had problems with all his blood components - an indicator of bone marrow problems.

Xofigo has little or no effect on PSA in most men. PSA is only a biomarker, and often not a very good one, especially if men are taking supplements that interfere with the assay.

I'm glad you think fenbendazole is working for you, and I hope it is

[Luucy in reply to Tall_Allen]

Thanks for your reply, glad to hear you are cured.

It is interesting you say his problems are an indicator of bone marrow problems.

I guess he will need to try to have another scan though not sure when this would likely to be.

[Luucy in reply to Tall_Allen]

Do you know whether a medication called G-CSF (granulocyte-colony stimulating factor), which can stimulate the bone marrow to produce more white blood cells might be an option.

I see it is given to people on the NHS who are undertaking chemo.

Thanks

[Tall_Allen in reply to Luucy]

G-CSF (Neulasta) to stimulate part of the immune system, erythropoeitin to stimulate red blood cell production and platelet-stimulating factors, are useless and possibly dangerous if the bone marrow is exhausted. If he had just one issue, stimulation might help, but with a global shutdown, you have to be careful. Talk to a hematologist.

[Luucy in reply to Tall_Allen]

Hi just wondering what you would suggest next for my dad please?

It looks like having just one dose of Radium 223 has knocked his immune system, and likely his cancer hasn't helped with low counts.

He has a few leg aches and back muscular aches he says, as if he's been driving for a while.

Also very swollen ankles.

Are there any possible options left he could look into?

He is wondering about restarting enzalutamide in case it works again, but he became hormone resistant so I don't think he should take it again.

Any advice appreciated?

[Tall_Allen in reply to Luucy]

Unfortunately, most clinical trials have minimum blood function limits. He might respond to estrogen patches?

[Luucy in reply to vivamais7]

Thanks for the reply, can you tell me more about Febendazole please, my father wants me to look into this for him. Thanks

[vivamais7 in reply to Luucy]

From my answer to Tall-Allen (probably a Doctor) you already know the story of my fight to live 17+ years without problems and a wonderful sex life I would have not had should I have accepted RP (a barbaric practice in my opinion). You also know the other treatments I made to date. Now I am on Fenbendazole with the approval of my Oncologist (an open minded Doctor).

I sugest you visit mycancerstory.rocks and Fenbendazole.com that inspired me to try this alternative therapy. From my experience I can tell you that it merits a try: no toxity, low cost, and up to now promising results. Just be careful with the elements of the Protocol:

I have been using Vitamin E Succinate (Allergy Research); Theracurmin (Natural Factors) ; CBD Oil (Sativida). Also I am taking Milk Thilste (Now Foods) to protect my liver.

Good luck for your father from this 83 young man.

[Tall_Allen in reply to vivamais7]

I'm not a doctor. Vitamin E has been proven to cause prostate cancer. Another antihelminthic, niclosamine, is in an early clinical trial with results expected this month. So far, trials have shown no therapeutic window for it. These types of drugs can be highly toxic, especially for those already debilitated by advanced cancer. This should be discussed with his oncologist.

[vivamais7 in reply to Tall_Allen]

Opinions just opinions without support.

On Niclosamine: ncbi.nlm.nih.gov/pmc/articl...

On Fenbendalole canceractive.com antiworm drug treatmeent

On Vitamine E Succinate (not just "natural vitamin e"):

urmc.rochester.edu/news/sto... ...

onlinelibrary.wiley.com/doi/full/10.1002/ijc/21689.

My oncologist is a real Doctor and supports me with what I am doing. Do not be so destructive. It's enough for me.

[Tall_Allen in reply to vivamais7]

No- I always can support what I write:

"Oral niclosamide could not be escalated above 500mg TID, and plasma concentrations were not consistently above the threshold shown to inhibit growth in CRPC models. Oral niclosamide is not a viable compound for repurposing as a CRPC treatment."

ncbi.nlm.nih.gov/pmc/articl...

When evaluating research, scientists abide by levels of evidence and GRADE standards that you evidently don't know about. When there is a large-scale randomized clinical trial like the SELECT trial, it becomes the standard of care. Whether or not different tocophererols are as harmful as Vitamin E cannot be determined without another large scale randomized clinical trial. Fortunately, most patients are prudent enough to not try anything so risky for so little potential benefit.

"Dietary supplementation with vitamin E significantly increased the risk of prostate cancer among healthy men."

jamanetwork.com/journals/ja...

Whatever you decide to do for yourself is your business, but don't encourage others to harm themselves.

[tom67inMA]

Hi Luucy, I'm currently in chemo with the expected roller coaster blood counts. My MO is also a hematologist, and my blood tests have also included things like reticulocyte counts, EPO, iron levels, etc. These tests are effectively a peek under the blood counts at the signaling and raw materials that the marrow needs to do its job. For example, low EPO would mean the marrow isn't getting a signal to make red blood cells.

One other thing he looks at is monocyte count. That's the type of white cell that comes back first. It's a learning indicator that other white cells are on their way back.

As for what to do about low counts, make sure he's getting sufficient calories and protein. This is one of the rare times I'm not going to recommend exercise. My anecdotal observation is that if I push myself too hard during chemo, my blood counts don't recover as well.

[Tall_Allen]

Unfortunately, your google searches only find lab studies- nothing "compelling." Only a very tiny proportion of "compelling" lab studies(and there are MANY!) turn out to have any clinical effectiveness. Wanting something to have clinical effectiveness doesn't make it true, no matter how much you or I want it to be true. I hope your beliefs turn out to be true.