Dipyridamole To Reduce Platelet Formation, inhibit Fibrin Coating

[Researchshortcut]

Has anyone taken the above with the hope of reducing/inhibiting metastasis, and tumor formation?

This is an old drug used for at risk stroke and heart attack patients. It is also an anti-inflammatory (COX-2 path) . It's primary purpose is to curtail the formation of platelets and platelet adhesion for stroke type risks, but this platelet formation is also used by cancer cells to spread to distant tissues.

The drug has a reputation for high tolerability, and little side effects. It is an Rx requirement and this, of course, would be an off label use requiring some back and forth with oncologist.

It was a Jane McClellean favorite .

Just wondering. I am stage 4 HSPCa, to the bone and lymph and on Lupron, Nubeqa at present after (6) Docetaxel, and Lupron. I am one of those that believes the use of many bullets is necessary to wound and slow the beast. Thought this might be low risk possibility.

Has anyone had any experience with this drug?

Jeff

[LearnAll]

It is well established that anti platelet therapy slows growth of metastasis. If you need more info, search my old thread about platelets and cancer.Platelets coat the circulating cancer cells and thus hide them from Macrophages and NK cells. The goal is to keep Platelet count in low normal range. And adding a mini aspirin helps further by not letting the platelets be sticky.

I keep my platelet levels in 120-140 range by eating 5 piper betel leaves with saffron threads Every single day. So far, for over 2 years, my platelet count is responding well to this harmless leaf which is eaten by over a billion people in the world every single day. Make sure not to put anything in leaf other than Saffron and Rose petals. Saffron has anti cancer substances like Crocin and Crocetin and Rose petals provide anthocyanins. Platelet count should not fall below 100 so adjust number of betel leaves according to platelet count.

[Researchshortcut in reply to LearnAll]

Hmmm……food for thought (pun unintended).

Thank you for sharing!

[dhccpa in reply to LearnAll]

You use that combo to raise or lower your platelets? First time I've seen you mention. Saffron's pretty price, isn't it?

[Tall_Allen]

Most men with PCa would love to have more platelets. You seem like a good candidate for Pluvicto, but not if you inhibit platelets. I think Jane McClellan is a whack-job.

[Researchshortcut in reply to Tall_Allen]

Thanks for the quick and honest response! I think I got your drift!

I still don’t know what to think of Jane in total. Her research was prolific for a lay person (no offense to physiotherapy as a profession in all honesty), but not medically without fault. There is no way I could or would attempt what she did, but there were interesting points laced through her research.

After all, I accepted the distilled bark of a yew tree as primary treatment. I m sure you know where I m headed.

I don’t think it is possible to discount the natural world, but the sheer volume of possibilities and combinations make it impossible to expect our profit driven medical world to fully explore.

So, I continue to look for non-toxic, low risk roadblocks to the cancer stem cell metabolism, from any reasonable source.

I do appreciate your point of view.

[Tall_Allen in reply to Researchshortcut]

Plants produce millions of chemicals, many are toxic (like taxanes), some are salubrious. One doesn't know which is what until they are tested. Thousands of plant-derived chemicals have been tested and some have been improved for our use. There are well-tested procedures for screening and testing. In fact, there is a whole branch of science, pharmacognosy, devoted to that.

[FRTHBST in reply to Tall_Allen]

Whether increase in platelet count is beneficial or problematic would seem to rely on particular stage in progression of disease and/or treatment regimen. In general for PCa and other solid tumors, higher platelet counts are associated with worse outcomes.

pubmed.ncbi.nlm.nih.gov/355...

pubmed.ncbi.nlm.nih.gov/345...

and lowering platelet count of some benefit following rt;

pubmed.ncbi.nlm.nih.gov/324...

To the extent that Dipyridamole can reduce platelet count, this may be good for many.

I would say that Jane McClellan's emphasis on newer metabolic approaches to cancer treatment is somewhat prophetic given the amount of basic science being pursued in that direction. Cancer is so complex and still so partially understood that counting any reasonable approach out at this point would be a bad bet.

[Tall_Allen in reply to FRTHBST]

In contrast to what you concluded, the first one actually said:

"We could not demonstrate an association between elevated platelet count and worse survival in our study population of patients with prostate cancer."

pubmed.ncbi.nlm.nih.gov/355...

The second one only found a correlation between some bloodwork and CTC count.

The third one found "Low platelet count was associated with inferior FFBF and FFDM after prostate radiotherapy. " which is the opposite of what you conclude.

There is no evidence that reducing platelet count is a good idea. Be careful about drawing erroneous conclusions - it can damage your health.

[FRTHBST in reply to Tall_Allen]

You are absolutely right. I was lazy in my quick reading. I apologize because when bad information is posted it could affect others as well as myself.

Basically upon careful reading, the relationship of platelet count to PCa progression is complex.

The first study did not support earlier studies finding a relationship between high platelet count and worse outcomes-thanks for pointing this out.

The third did find a relationship between platelet count, outcomes and medication to prevent thrombosis, though as you point out, low platelet counts were associated with worse outcomes. I think this finding might be relevant in discussing Dipyridamole as an anti -thrombosis medication, not in lowering platelet count. But if one did have a low platelet count, medications such as Dipyridamole might be beneficial for cancer outcomes.

Still further reading; pubmed.ncbi.nlm.nih.gov/344... "Preferential interaction of platelets with prostate cancer cells with stem cell markers" explores a complex relationship of specific platelets "activated" by interaction with cancer stem cells.

The first study notes that high platelet counts have been associated with worse outcomes in many solid tumor types, that this observation doesn't hold up in regard to PCa provides yet another warning against generalizing information across different cancers. And prostate cancer is different. Platelets may well be involved in metastasis of PCa, not in a simple count of high or low.

[Medline]

Interestingly, the use of dipyridamole is associated with a lower risk of lymphoid neoplasms!

onlinelibrary.wiley.com/doi...

[Researchshortcut in reply to Medline]

That was interesting and unknown to me. Thanks.

[Bigm789]

pubmed.ncbi.nlm.nih.gov/311...

[LearnAll]

The men with PCa whose bone marrow is impaired and is not producing enough platelets ...Need higher platelets. This does not apply to men who still has bone marrow UNAFFECTED and churning out enough platelets. This confusion happens when poster does not qualify the answer and make sweeping generalizations and the goal is keep the "fear level" high. Big Pharma and the OI complex and their paid agents ..are anti herbs and Anti Plants BUT the same entities are trying to spend millions in research to extract some plant based chemical and sell it for thousands of dollar a month . So this anti plant, anti herb, anti exercise, anti nutrition propaganda serves the purpose of these entities but does not help real patients.

[Graham49]

33 minutes agoDetails

ldoi.org/10.1016/j.molmet.20...

Here's another paper (only in vitro though) that indicates statin and dipyridamole combination may be a benefit for treatment prostate cancer

[Researchshortcut in reply to Graham49]

Thanks for the article. It is interesting and provokes some thought on potential statin/dipyridamole. Begs further questions at worst.