PSA rising after clinical trail

[Moco1]

Psa in 2018 diagnosed with biopsy gleason 9. Has prostate robotically removed psa went to undetectable .05 from MSK.

Year later climbed to 1.7. Had psma done and "bone met " on sitting bone" Had radiation 3 times to that bone and 40 times to pelvic bed which psma showed cells..

Participated in clinical trial with enzalutamide 30 months ago psa was undetectable in February 2022

March 2022 had pain in that bone psa was .07

I had a bone scan as well as CT scan and no "uptick" thenin April 2022 psa climbed to .11

Next appointment in August for psa . Guidelines are psa needs to be at least .2 to take another psma.

Any input is appreciated on what I can expect.

Moco

[Tall_Allen]

Your break from hormone therapy is ending. But it's up to you when to restart it.

[Moco1 in reply to Tall_Allen]

What is the best I can hope for and how many times can this happen.? If PSA goes to undetectable after therapy and lasts another 30 months can be done again again ?

[Tall_Allen in reply to Moco1]

No way of knowing

[Moco1 in reply to Tall_Allen]

Thank you for response. Aren’t there statistics?

[Tall_Allen in reply to Moco1]

No- Everyone does iADT differently.

[Moco1 in reply to Tall_Allen]

Thank you again. Does the fact that I reacted well to the last therapy indicate a positive outcome ?

[Tall_Allen in reply to Moco1]

Sounds good to me.

[Magnus1964]

Wait for another PSA test, if it's up again, it may be time to move to zytiga

[HopingForTheBest1]

Have you had genetic testing?

[Moco1]

I have not. will discuss with my oncologist in August. Ty