Rising PSA after SBRT : 3 weeks ago I... - Advanced Prostate...

Advanced Prostate Cancer

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Rising PSA after SBRT

John347 profile image
9 Replies

3 weeks ago I had 5 rounds of SBRT after a PSMA scan showed a spot suspicious of bone met. Yesterday, I went for my blood test...my PSA had risen to 14.9 from 8.5 in March.I had expected the PSA to decline after SBRT. What does the increase in PSA mean? That the rib met was a false positive?

What are the recommended treatments now going forward? I'm meeting my oncologist tomorrow...what questions should I ask him?

Thanks for any advice.

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John347
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9 Replies
Tall_Allen profile image
Tall_Allen

It means dead cancer cells dump a lot of PSA into the bloodstream. Test again in 2 months.

John347 profile image
John347 in reply to Tall_Allen

So I need not be unduly concerned by the rise? Thanks for your reply Allen.Should I ask for ADT to start immediately or wait for the PSA test then decide?

in reply to John347

I keep reading this:

Surprisingly, research suggests that radiation patients who go through a bounce actually have better long-term outcomes than those who don’t. 

Tall_Allen profile image
Tall_Allen in reply to

That's not a bounce. Bounces refer to prostate treatment.

in reply to Tall_Allen

ncbi.nlm.nih.gov/pmc/articl....

Alturia profile image
Alturia in reply to

The article that you cite refers to treatment of the prostate, not treatment of metastases as Tall_Allen has noted.

in reply to Alturia

you only read the yellow paragraph. Which was explanatory

if you kept reading

Our case suggests that this effect can also be seen in patients who have undergone previous radical prostatectomy and PSA bounce should be considered in patients with a PSA rise following salvage radiotherapy.

Alturia profile image
Alturia in reply to

Salvage radiotherapy and/or previous RALP still are not the same as radiation to distant metastases.

Tall_Allen profile image
Tall_Allen in reply to John347

You should never be off ADT, unless you need a break.

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