Lynparaza and Testosterone?

[nuc1111]

Some small trials have shown benefit---has anyone had personal experience? Thanks

[Tall_Allen]

There was only one clinical trial that I'm aware of. The results were equivocal:

30 heavily-pretreated men who were mCRPC and who have progressed on either Zytiga or Xtandi, received BAT and the PARP inhibitor olaparib. Half had DNA damage repair defects.

• ¾ had at least some PSA reduction

• 47% had a PSA reduction ≥ 50% (44% if 2 who dropped out for progression are added)

• 23% had a 12-wk PSA increase ≥50% (28% if 2 who dropped out for progression are added)

• Median progression-free survival was 14.8 months if they were mutation-free vs. 7.5 months if they had the defects.

• 2 patients had a complete PSA response

• 5 of 8 90+% responders were free of DNA damage repair defects

• 3 of 6 90+% progressors had DNA damage repair defects

• 5 patients had serious (grade ≥ 3) toxicity, including one death

• Excellent responders had mutations of the T53 gene or DNA repair genes

urotoday.com/conference-hig...

More interesting (I think) were the trials combining PARP inhibitors with abiraterone:

prostatecancer.news/2022/06...

[tango65]

Thanks for the posting. Something to have in mind after failing the new anti androgens.

[HopingForTheBest1]

Lynparza was very effective for me being BRCA2+. Lasted almost 2 years, keeping my PSA undetectable, until it ran its course.

[nuc1111 in reply to HopingForTheBest1]

Thank you-Ed

[Shooter1 in reply to HopingForTheBest1]

Why does it always seem that all of our treatments run their course and then drop us back into the mud ???

[HopingForTheBest1 in reply to Shooter1]

We just have to try our best to get back up after being knocked down again and again. Keep researching, ask questions, and challenge your doctors.

[Shooter1 in reply to HopingForTheBest1]

Well, BAT is next. My MO has never done it , but has been consulting with other drs to see what they have done... He is now on board as he has run out of other treatments.... We'll see if it works for me.... Life Is Good, especially when you have at least one more treatment lined up to fight this beast.