What I have read is slow decline is better and in extension of life as TomTom said down is good because while going down it isn't going up. In the past TA has said that the nadir or lowest it goes is also relevant. I almost positive it is possible for Stage 4 to reach undetectable.
From all of the articles I've read on this (I think our diagnoses were pretty similar), my understanding is this. Anything under 0.1 is remission. Anything under 0.05 is considered undetectable. Re the rate of deceleration, I don't know. All of us will produce some PSA if you still have a prostate. You should also remember that the PSA test is considered somewhat unreliable. I understand that a professor at Queen's university in Belfast is working on a better test. It's when it starts to rise rapidly that one should be concerned. My own PSA hovered around 0.18 while on enzalutamide. The doctor told me that radiotherapy would kill off the remaining stubborn cancer producing cells in the prostate. And it did this.
Really, Really good I say. 2 years and you have not had a PSA rise. You are still on basic ADT. You have not had to move onto Zytiga or other 2nd line ADT.
PS I forgot to answer your last question. From what I've read, and I'm not a doctor, yes, it is possible for your PSA to become undetectable even though you have stage 4 prostate cancer. But, at the risk of repetition, the PSA test is not a 100% accurate determinant of prostate cancer so even if the reading was zero, you will still have prostate cancer cells lurking in your body. Furthermore, when I was diagnosed, my PSA was 10.79. But I was told that my scans suggested much wider spread of the disease in my body than a reading of 10.79.
Hang on in there. The cure is around the corner.
Congratulations 🥳 You’ve hit the first mark in survival. I was #4 and I’ve now been undetectable over five years. I’m still on a pill adt stopping adrenal . By you keeping up your strength and workout it bodes well . Keep keeping on big guy! Ride this good news . Some have lived for decades past #4 .
Congratulations. It took about a year to reach my PSA nadir and it has basically stayed quite low since then. Each time I have scans done, my tumours continue to get smaller. My latest scans, more than three years after diagnosis, show that the bone mets are no longer visible.
I hope we both continue to have great results for years to come.
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