MY HUSBAND HAS BEEN ON LUPRON FOR 8 YEARS. HIS PSA ROSE TO 1.6 FROM .5 IN 1 MONTH . WE CONTINUED WITH HIS TREATMENT AND FOR THE LAST 3 MONTHS HIS PSA HAS DECLINED EVERY MONTH AND NOW DOWN TO .89.
THIS HASN'T HAPPENED TO US EVER, AND OUR ONCOL. AS WELL AS WE ARE THRILLED.
HAS ANYONE EXPERIENCED THIS?
THANKS
BOOGEE
Written by
ROLNCIN1
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Lupron may be failing. He has gotten a lot of years out of it!!!!!!! He responds well to treatment. His PSA is still low so don't panic. Maybe it's time to move on new treatments i.e. Caxodex, Xtandi, Zytiga, and some chemotherapy.
It's good news -sometimes the cancer is more active than other times. Now that he is officially "castration resistant" it allows him to get a wider range of medicines.
We thought once his psa increases while on treatment he is castrate resistant and that may still be the case, however it has gone down for 3 straight months.
Had been .5 and in 1 month went to 1.6.
It now is .89.
Oncol. wants to stay with this Lupron treatment monthly until or when it reaches 2 or above.
I have been on Eligard/Lupron for seven years and I have had fluctuations. I went from 0.45 to 0.06 in my fifth year and six months later it was 0.06 again, and then six months later 0.21. And now 0.40. I specifically asked if this is an indicator of resistance. The answer was "maybe...have a nice summer and we will check again in the fall." I should add, though, that I am on IP-6 with the Lupron and my doctors know it. They act scornful of supplements, but they respect Dr. Shamsuddin. Also, making my situation a little tricky for my physicians is the fact I have an intact prostate as the metastases precluded surgery or radiation in 2012. I have never had either.
Your husband has good suppression of T, so the Lupron is doing its job. Go out and enjoy life.
I hope you understand that when you use Lupron you are "fooling" the pituitary gland by telling it to send out a hormone to stop the production of androgens throughout the body. This is called "chemical castration". After a while the pituitary catches on and stops sending out this hormone, and the patient is "castration resistant". I have seen on this website many men have said they believe that everyone taking shots for castration will all eventually become castration resistant. You understand that when the PSA goes up it means that somewhere in the body prostate cells are multiplying. Your doctor should find other chemical agents to use in this case. I wish you well.
Yes we understand that to be true. My husband has been on continuous Lupron for 8 years, so we were just shocked as it has started going down now while on the same treatment.
Next month will be the 4th month {if it drops} again. My husband gets monthly treatment of Lupron.
One month he was at .50 and then in 1 month it jumped to 1.60 in 1 month and started declining continually.
He now is .86
I say we as my husband and I are a team re: this dreaded disease.
BTW our Oncol. will consider changing treatments if or when the PSA reaches 2 or above.
Since the PSA has reversed itself there is no reason for immediate concern. If he is on Lupron and the PSA begins to again show signs of increasing the first thing you should do is confirm that he is still castrate by having his testosterone level checked (a blood test). His testosterone level should be below 20 ng/ml. If it isn't then the doctor should be changing the hormone manipulation (possibly gong over to Firmagon).
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