TRUP vs. alternatives: New info from... - Advanced Prostate...

Advanced Prostate Cancer

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TRUP vs. alternatives

Scout4answers profile image
13 Replies

New info from meeting with RO Yesterday he says because my prostate is enlarged ( 158 grams estimate from MRI, about 5 x normal) he thinks that having a TURP prior to radiation might be a good idea.

His thinking is; radiation may swell my prostate and if my urethra were to close off flow during the 28 day procedure they would have to go in and do a TRUP at that point and it would be worse as the radiation could complicate the healing of the urethrae.

From Mayo Clinic web site

Overview

Enlarged prostate with benign prostatic hyperplasia compared with normal prostate

Benign prostatic hyperplasia (BPH)Open pop-up dialog box

Transurethral resection of the prostate (TURP) is a surgery used to treat urinary problems that are caused by an enlarged prostate.

An instrument called a resectoscope is inserted through the tip of your penis and into the tube that carries urine from your bladder (urethra). The resectoscope helps your doctor see and trim away excess prostate tissue that's blocking urine flow.

TURP is generally considered an option for men who have moderate to severe urinary problems that haven't responded to medication. While TURP has been considered the most effective treatment for an enlarged prostate, a number of other, minimally invasive procedures are becoming more effective. These procedures generally cause fewer complications and have a quicker recovery period than TURP.

Here are some of the alternatives I have found:

Does anyone have experience with any of these

Traditional Treatment Methods for Enlarged Prostate

Treatment options

Alpha blockers

5-alpha reductase inhibitors

Combination therapy

TUMT

TUNA

Water-induced thermotherapy

Surgery

Laser surgery

Open simple prostatectomy

Lifestyle changes

Recognizing BPH

If trips to the restroom require sudden dashes or are marked by difficulty urinating, your prostate may be enlarged. You’re not alone — the Urology Care Foundation estimates that 50 percent of men in their 50s have an enlarged prostate. The prostate is the gland that produces the fluid that carries sperm. It grows larger with age. An enlarged prostate, or benign prostatic hyperplasia (BPH), can block the urethra from transporting urine from the bladder and out of the penis.

Keep reading to learn about traditional treatments for BPH.

BPH treatment options

Don’t resign yourself to living with BPH. Addressing your symptoms now can help you avoid problems later. Untreated BPH may lead to urinary tract infections, acute urinary retention (you can’t go at all), and kidney and bladder stones. In severe cases it can lead to kidney damage.

Treatment options include medications and surgery. You and your doctor will consider several factors when you evaluate these choices. These factors include:

how much your symptoms interfere with your life

the size of your prostate

your age

your overall health

any other medical conditions

Alpha blockers for BPH

This class of medications works by relaxing the bladder neck muscles and the muscle fibers in the prostate. The muscle relaxation makes it easier to urinate. You can expect an increase in urine flow and a less frequent need to urinate within a day or two if you take an alpha blocker for BPH. Alpha blockers include:

alfuzosin (Uroxatral)

doxazosin (Cardura)

silodosin (Rapaflo)

tamsulosin (Flomax)

terazosin (Hytrin)

5-alpha reductase inhibitors for BPH

This type of medication reduces the size of the prostate gland by blocking hormones that spur the growth of your prostate gland. Dutasteride (Avodart) and finasteride (Proscar) are two types of 5-alpha reductase inhibitors. You’ll generally have to wait three to six months for symptom relief with 5-alpha reductase inhibitors.

Medication combo

Taking a combination of an alpha blocker and a 5-alpha reductase inhibitor provides greater symptom relief than taking either one of these drugs alone, according to an article in Current Drug TargetsTrusted Source. Combination therapy is often recommended when an alpha blocker or 5-alpha reductase inhibitor isn’t working on its own. Common combinations that doctors prescribe are finasteride and doxazosin or dutasteride and tamsulosin (Jalyn). The dutasteride and tamsulosin combination comes as two drugs combined into a single tablet.

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Stand the heat

There are minimally invasive surgery options when drug therapy isn’t enough to relieve BPH symptoms. These procedures include transurethral microwave thermotherapy (TUMT). Microwaves destroy prostate tissue with heat during this outpatient procedure.

TUMT will not cure BPH. The procedure does cut down urinary frequency, makes it easier to urinate, and reduces weak flow. It doesn’t solve the problem of incomplete emptying of the bladder.

TUNA treatment

TUNA stands for transurethral needle ablation. High-frequency radio waves, delivered through twin needles, burn a specific region of the prostate in this procedure. TUNA results in better urine flow and relieves BPH symptoms with fewer complications than invasive surgery.

This outpatient procedure can cause a burning sensation. The sensation can be managed by using an anesthetic to block the nerves in and around the prostate.

Getting in hot water

Hot water is delivered through a catheter to a treatment balloon that sits in the center of the prostate in water-induced thermotherapy. This computer-controlled procedure heats a defined area of the prostate while neighboring tissues are protected. The heat destroys the problematic tissue. The tissue is then either excreted through urine or reabsorbed in the body.

Surgical choices

Invasive surgery for BPH includes transurethral surgery, which doesn’t require open surgery or an external incision. According to the National Institutes of HealthTrusted Source, transurethral resection of the prostate is the first choice of surgeries for BPH. The surgeon removes prostate tissue obstructing the urethra using a resectoscope inserted through the penis during TURP.

Another method is transurethral incision of the prostate (TUIP). During TUIP, the surgeon makes incisions in the neck of the bladder and in the prostate. This serves to widen the urethra and increase urine flow.

Laser surgery

Laser surgery for BPH involves inserting a scope through the penis tip into the urethra. A laser passed through the scope removes prostate tissue by ablation (melting) or enucleation (cutting). The laser melts excess prostate tissue in photoselective vaporization of the prostate (PVP).

Holmium laser ablation of the prostate (HoLAP) is similar, but a different type of laser is used. The surgeon uses two instruments for Holmium laser enucleation of the prostate (HoLEP): a laser to cut and remove excess tissue and a morcellator to slice extra tissue into small segments that are removed.

Open simple prostatectomy

Open surgery may be required in complicated cases of a very enlarged prostate, bladder damage, or other problems. In open simple prostatectomy, the surgeon makes an incision below the navel or several small incisions in the abdomen via laparoscopy. Unlike prostatectomy for prostate cancer when the entire prostate gland is removed, in open simple prostatectomy the surgeon removes only the portion of the prostate blocking urine flow.

Self-care may help

Not all men with BPH need medication or surgery. These steps may help you manage mild symptoms:

Do pelvic-strengthening exercises.

Stay active.

Decrease alcohol and caffeine intake.

Space out how much you drink rather than drinking a lot at once.

Urinate when the urge strikes — don’t wait.

Avoid decongestants and antihistamines.

Talk with your doctor about the treatment approach that best suits your needs.

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Scout4answers
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13 Replies
Tall_Allen profile image
Tall_Allen

High rate of incontinence for TURP+RT. Ideally, you would wait a year or two after. Or you can have a prostatectomy instead.

meowlicious99 profile image
meowlicious99 in reply toTall_Allen

Allen any references to high rate of incontinence . Dad is getting rt near term after his turp. Want to read more about incontinence issues.

Tall_Allen profile image
Tall_Allen in reply tomeowlicious99

journals.lww.com/amjclinica...

redjournal.org/article/S036...

For men with high risk PCa, ADT can continue until tissues are healed before starting radiation.

cesces profile image
cesces

1. I recollect that mine was larger than yours. I had no problems.

2. Get some second opinions. And ask them how many times they have done this in the past.

3. Going in and disrupting all that tissue in order to avoid using a catheter? Seems like you are risking a lot for a little.

Maybe not such a good trade? LoL

4. Get some second opinions. Measure twice, cut once.

Literally. LoL

Scout4answers profile image
Scout4answers in reply tocesces

worse yet they put a temporary catheter in during the procedure

We are on the same page

meowlicious99 profile image
meowlicious99 in reply toScout4answers

my dad had bipolar turp 2 weeks ago. Catheter was gone after day 2 of surgery. So far so good.

Scout4answers profile image
Scout4answers in reply tomeowlicious99

Thanks Meow

very helpful

here is a study I found comparing them

Comparative Study Urol J

. 2015 Dec 23;12(6):2452-6.

Safety and Efficacy of Bipolar Versus Monopolar Transurethral Resection of the Prostate: A Comparative Study

Erkan Hirik 1, Aliseydi Bozkurt 1, Mehmet Karabakan 2, Huseyin Aydemir 3, Binhan Kagan Aktas 4, Baris Nuhoglu 1

Affiliations expand

PMID: 26706745

Free article

Abstract

Purpose: Transurethral resection of the prostate (TURP) is considered gold standard for surgical treatment of benign prostatic hyperplasia (BPH). In this study, we aimed to compare post-operative clinical outcomes and adverse effects between monopolar and bipolar TURPs.

Materials and methods: The study included 590 patients who underwent TURP by a single urologist (E.H.) between June 2006 and June 2014 with a diagnosis of BPH. Patients were divided into two groups as monopolar TURP (group 1, n = 300) and bipolar TURP (group 2, n = 290). Patients receiving oral anticoagulants or aspirin and those with prostate cancer diagnosis were not included in the study. Data regarding pre-operative age, International Prostate Symptom Score (IPSS), maximum urinary flow rate (Qmax), post voiding residual urine volume (PVR), serum prostate specific antigen (PSA) levels and prostate volume (Vp) of the patients were gathered from medical records. Groups were compared in terms of catheterization, operation time, hemoglobin (Hb) decrease, and IPSS, Qmax, and PVR values at post-operative 12th month follow-up visit.

Results: From pre-operative to post-operative period, IPSS, Qmax and PVR showed significant improvements within both groups (P < .001). When groups were compared with each other, bipolar TURP group had significantly lesser catheterization time and hemoglobin decrease than monopolar TURP group, while no significant differences were detected regarding all other variables.

Conclusion: Bipolar and monopolar TURPs are both effective and safe treatment modality for BPH. Bipolar TURP is superior to conventional monopolar TURP in terms of catheterization time and Hb decrease.

Comment in

Re: Safety and Efficacy of Bipolar versus Monopolar Transurethral Resection of the Prostate: A Comparative Study.

Kaplan SA.

J Urol. 2017 Jun;197(6):1530. doi: 10.1016/j.juro.2017.03.085. Epub 2017 Mar 17.

PMID: 28505927 No abstract available.

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980-Nm Diode Laser Vaporization versus Transurethral Resection of the Prostate for Benign Prostatic Hyperplasia: Randomized Controlled Study.

Cetinkaya M, Onem K, Rifaioglu MM, Yalcin V.

Urol J. 2015 Nov 14;12(5):2355-61.

PMID: 26571321 Clinical Trial.

Comparative randomized study on the efficaciousness of endoscopic bipolar prostate resection versus monopolar resection technique. 3 year follow-up.

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Lasers Med Sci. 2018 Sep;33(7):1411-1421. doi: 10.1007/s10103-018-2539-0. Epub 2018 Jun 27.

PMID: 29947009 Review.

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Cited by 1 article

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Publication types

Comparative Study

Gemlin_ profile image
Gemlin_

Very large prostate volume caused by benign prostate enlargement means large radiation volume with increased risk of side effects from the urinary tract and rectum. Have you considered prostatectomy + extended pelvic lymph node dissection?

MateoBeach profile image
MateoBeach

If you are able to urinate adequately despite the BPH, then I would be loathe to have a TURP prior to definitive treatment, either your planned RT with adjuvant ADT or prostatectomy. Might be of more benefit for the urologist than for you. - TURP is their go-to hammer. Let the RO assess the anatomy and advise on risks with RT for your particular anatomy and organs-at-risk.

Fairway profile image
Fairway

No expertise this area, Scout. Just sending all best wishes for your complete recovery. Fairway

Scout4answers profile image
Scout4answers in reply toFairway

Thanks for the kind words Fairway. Hope to be where you are at in 5 years

j-o-h-n profile image
j-o-h-n

Ahoy Captain Ahab what to do off the starboard bow?: Dar she blows....Moby Dick........

Good Luck, Good Health and Good Humor.

j-o-h-n Friday 10/29/2021 11:30 PM DST

Doseydoe profile image
Doseydoe

I've had a TURP and about 8 months later a TURBT, all character building. My point is in my case they were both needed. Bite the bullet and get it done but if your medical team just think it might be worthwhile, then I suggest a cuppa tea and a re-think.

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