Experiences with

Dutasteride

Has anyone used Bicalutamide & Dutasteride for keeping localized PCa stable during AS?

I've only taken 02 pills of dutasteride + tamsulosin hydrochloride, and already no sperm during orgasm. Pretty fast, right? I'm very worried about the side effects of this medication and how long I need to take it. And the consequences... Can anyone enlighten me, please?

These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to PSA Failure. In the upper plot, Dutasteride increases the Doubling Time from, for example, 9 months to 18 months (factor of 2X).

These two Kaplan-Meier plots compare Dutasteride (0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to PSA Failure. In the upper plot, Dutasteride increases the Doubling Time from, for example, 9 months to 18 months (factor of 2X).

This study by Finelli et al. (2010) looks at the effect of Dutasteride (5-ARI) on the rate of prostate cancer disease progression in Low-Risk men on Active Surveillance.

Here is a library of 20 papers about using Dutasteride to treat prostate cancer. In one study, Dutasteride monotherapy reduces PSA by 50%, reduces prostate volume by 25%, and reduces tumor volume by 30%, after 6 months of treatment, compared to placebo (Moore, 2017).

This companion chart from data reported in Moore (2017) compares PSA, at baseline and at 6 months, comparing placebo to Dutasteride. This was a randomized, double-blind, placebo-controlled clinical trial.

This chart compares prostate cancer tumor volume measured by MRI, at baseline and at 6 months, comparing placebo to Dutasteride. This was a randomized, double-blind, placebo-controlled clinical trial.

Taking 0.5 mg/day of Dutasteride reduces the normal DHT level by 94.7 % to about 24 pg/mL (reduction factor = 19X). Increasing the Dutasteride dose to 2.5 mg/day reduces the normal DHT level by 97.7% to about 10 pg/mL (reduction factor = 40X).

Taking 0.5 mg/day of Dutasteride reduces the normal DHT level by 94.7 % to about 24 pg/mL (reduction factor = 19X). Increasing the Dutasteride dose to 2.5 mg/day reduces the normal DHT level by 97.7% to about 10 pg/mL (reduction factor = 40X).

About 15% of men in Group A are non-responders, and about 35-40% of men in Group B are non-responders to Dutasteride monotherapy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757197/

I am a little bit uncomfotable about discontinuing bicalutamide and dutasteride.....

Here is the single best paper reviewing the three major trials that compared Dutasteride to placebo for men with PCa.

This plot that I made goes back to the original paper by Thompson et al. (2003), that was the basis for slapping the Black Box Warning Label on Dutasteride prescriptions.

The trial examines whether enzalutamide combined with dutasteride or finasteride can effectively manage prostate cancer while avoiding ADT.

Dutasteride decreases DHT levels by more then 90%, which is why there is such a dramatic decrease in PSA levels. DHT is the fuel that feeds prostate cancer growth, not testosterone. Dutasteride also shrinks the prostate by 25-50%, as well as reducing the risk of PCa by 20%.

As the resuly of my rising PSA of 7.3 , I have been on Dutasteride for 4 yars for BPH , I proceeded to have a Tesla 3.0 Prostate MRI which showed an increased T2 Signal plus a PI - RADS 5 . highly suspicious of cancer .

I've read that you are supposed to double the PSA to get an "equivalent" non-dutasteride level of 11. Does anyone understand why we are supposed to double the PSA value when taking dutasteride?

They were compared to people who took two other types of prostate drugs that do not activate the same enzyme—tamsulosin and the 5α-reductase inhibitors finasteride and dutasteride, called 5ARIs.

**I would also like to add that i have read Vitamin B12 can help Tinnitus,so i take 1000ug Vitamin B12 dual power (methlcobalamin 666ug and Adenosylcobalamin 334ug) As well as 5000iu Vitamin D3 + K2 (100mcg) Multivitamins Biotin 12000ug Cod Liver Oil also Dutasteride (0.5mg) & Oral Minoxidil (2.5mg)