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Dutasteride increases PSA Doubling Time after PSA Recurrence
These two Kaplan-Meier plots compare
Dutasteride
(0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot,
Dutasteride
increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X).
These two Kaplan-Meier plots compare
Dutasteride
(0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot,
Dutasteride
increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X).
janebob99
in
Advanced Prostate Cancer
1 month ago
Dutssteride increases PSA Doubling Time by 2X for men with PSA Failure.
These two Kaplan-Meier plots compare
Dutasteride
(0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot,
Dutasteride
increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X).
These two Kaplan-Meier plots compare
Dutasteride
(0.5 mg/day) to Placebo in a randomized, double-blind trial from 2012 of 187 men who have progressed to
PSA Failure.
In the upper plot,
Dutasteride
increases the
Doubling Time
from, for example, 9 months to 18 months (factor of 2X).
janebob99
in
Prostate Cancer Network
1 month ago
Should the dose of Dutasteride be increased?
Taking 0.5 mg/day of
Dutasteride
reduces the normal DHT level by 94.7 % to about 24 pg/mL (reduction factor = 19X). Increasing the
Dutasteride
dose to 2.5 mg/day reduces the normal DHT level by 97.7% to about 10 pg/mL (reduction factor = 40X).
Taking 0.5 mg/day of
Dutasteride
reduces the normal DHT level by 94.7 % to about 24 pg/mL (reduction factor = 19X). Increasing the
Dutasteride
dose to 2.5 mg/day reduces the normal DHT level by 97.7% to about 10 pg/mL (reduction factor = 40X).
janebob99
in
Advanced Prostate Cancer
2 months ago
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Should the dose of Dutasteride be increased?
Taking 0.5 mg/day of
Dutasteride
reduces the normal DHT level by 94.7 % to about 24 pg/mL (reduction factor = 19X). Increasing the
Dutasteride
dose to 2.5 mg/day reduces the normal DHT level by 97.7% to about 10 pg/mL (reduction factor = 40X).
Taking 0.5 mg/day of
Dutasteride
reduces the normal DHT level by 94.7 % to about 24 pg/mL (reduction factor = 19X). Increasing the
Dutasteride
dose to 2.5 mg/day reduces the normal DHT level by 97.7% to about 10 pg/mL (reduction factor = 40X).
janebob99
in
Prostate Cancer Network
2 months ago
Dutasteride (5-ARI) extends time to disease progression in Low-Risk men on Active Surveillance, compared to Placebo
This study by Finelli et al. (2010) looks at the effect of
Dutasteride
(5-ARI) on the rate of prostate cancer disease progression in Low-Risk men on Active Surveillance.
This study by Finelli et al. (2010) looks at the effect of
Dutasteride
(5-ARI) on the rate of prostate cancer disease progression in Low-Risk men on Active Surveillance.
janebob99
in
Prostate Cancer Network
19 days ago
Dutasteride reduces PSA by 40% over 6 months
This companion chart from data reported in Moore (2017) compares PSA, at baseline and at 6 months, comparing placebo to
Dutasteride
. This was a randomized, double-blind, placebo-controlled clinical trial.
This companion chart from data reported in Moore (2017) compares PSA, at baseline and at 6 months, comparing placebo to
Dutasteride
. This was a randomized, double-blind, placebo-controlled clinical trial.
janebob99
in
Prostate Cancer Network
1 month ago
Dutasteride Reduces Tumor Volume by 30% after 6 months.
This chart compares prostate cancer tumor volume measured by MRI, at baseline and at 6 months, comparing placebo to
Dutasteride
. This was a randomized, double-blind, placebo-controlled clinical trial.
This chart compares prostate cancer tumor volume measured by MRI, at baseline and at 6 months, comparing placebo to
Dutasteride
. This was a randomized, double-blind, placebo-controlled clinical trial.
janebob99
in
Prostate Cancer Network
1 month ago
PSA and Eligard and bicalutamide
I am a little bit uncomfotable about discontinuing bicalutamide and
dutasteride
.....
I am a little bit uncomfotable about discontinuing bicalutamide and
dutasteride
.....
Domas
in
Advanced Prostate Cancer
1 month ago
Dutasteride Monotherapy is effective for Newly Diagnosed PCa men not on ADT
About 15% of men in Group A are non-responders, and about 35-40% of men in Group B are non-responders to
Dutasteride
monotherapy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757197/
About 15% of men in Group A are non-responders, and about 35-40% of men in Group B are non-responders to
Dutasteride
monotherapy. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7757197/
janebob99
in
Prostate Cancer Network
1 month ago
Reference Library of Papers about Dutasteride for Treating Prostate Cancer
Here is a library of 20 papers about using
Dutasteride
to treat prostate cancer. In one study,
Dutasteride
monotherapy reduces PSA by 50%, reduces prostate volume by 25%, and reduces tumor volume by 30%, after 6 months of treatment, compared to placebo (Moore, 2017).
Here is a library of 20 papers about using
Dutasteride
to treat prostate cancer. In one study,
Dutasteride
monotherapy reduces PSA by 50%, reduces prostate volume by 25%, and reduces tumor volume by 30%, after 6 months of treatment, compared to placebo (Moore, 2017).
janebob99
in
Advanced Prostate Cancer
21 days ago
Dutasteride and PSA dropping
I've read that you are supposed to double the PSA to get an "equivalent" non-
dutasteride
level of 11. Does anyone understand why we are supposed to double the PSA value when taking
dutasteride
?
I've read that you are supposed to double the PSA to get an "equivalent" non-
dutasteride
level of 11. Does anyone understand why we are supposed to double the PSA value when taking
dutasteride
?
janebob99
in
Prostate Cancer Network
4 months ago
My own PSA values over time: 70% drop in just 3 months on Dutasteride and no ADT
Dutasteride
decreases
DHT
levels by more then 90%, which is why there is such a dramatic decrease in PSA levels.
DHT
is the fuel that feeds prostate cancer growth, not testosterone.
Dutasteride
also shrinks the prostate by 25-50%, as well as reducing the risk of PCa by 20%.
Dutasteride
decreases
DHT
levels by more then 90%, which is why there is such a dramatic decrease in PSA levels.
DHT
is the fuel that feeds prostate cancer growth, not testosterone.
Dutasteride
also shrinks the prostate by 25-50%, as well as reducing the risk of PCa by 20%.
janebob99
in
Prostate Cancer Network
2 months ago
Dutasteride Black Box Warning Label is Inappropriate.
This plot that I made goes back to the original paper by Thompson et al. (2003), that was the basis for slapping the Black Box Warning Label on
Dutasteride
prescriptions.
This plot that I made goes back to the original paper by Thompson et al. (2003), that was the basis for slapping the Black Box Warning Label on
Dutasteride
prescriptions.
janebob99
in
Prostate Cancer Network
1 month ago
Why don't doctors prescribe Dutasteride more often?
Here is the single best paper reviewing the three major trials that compared
Dutasteride
to placebo for men with PCa.
Here is the single best paper reviewing the three major trials that compared
Dutasteride
to placebo for men with PCa.
janebob99
in
Prostate Cancer Network
22 days ago
Bicalutamide and Eligard
Doctor recommend Eligard (Lupron) with bicalutimide and
dutasteride
. No choice. I went thru thus on Jan 10, 2024. Hospital said I have to run thru Eligard for 24 months on a quarterly basis. Every 3 month. Doctor Said Eligard works only for 2 years, and I have to find another drug thereafter.
Doctor recommend Eligard (Lupron) with bicalutimide and
dutasteride
. No choice. I went thru thus on Jan 10, 2024. Hospital said I have to run thru Eligard for 24 months on a quarterly basis. Every 3 month. Doctor Said Eligard works only for 2 years, and I have to find another drug thereafter.
Domas
in
Advanced Prostate Cancer
3 months ago
Dental Issues on Finesteride
She suggested
dutasteride
but with similar mechanism of action I want no part of that either. I will be 74 in a few weeks. I received full gland HIFU ablation surgery in 2016. I received a 6 month eligard shot months before that. Since then I have been off ADT. Oh, I had a pylarify scan Sept '23.
She suggested
dutasteride
but with similar mechanism of action I want no part of that either. I will be 74 in a few weeks. I received full gland HIFU ablation surgery in 2016. I received a 6 month eligard shot months before that. Since then I have been off ADT. Oh, I had a pylarify scan Sept '23.
fast_eddie
in
Fight Prostate Cancer
3 months ago
Any Data or MO Advice Regarding Dutasteride / Finasteride At Very Early Biochemical Recurrence?
Does anyone know of any studies or MO advice they've gotten regarding use of
Dutasteride
or Finasteride at very early signs of Biochemical Reccurrence (uPSA in the 0.03 - 0.1 range) prior to Salvage Radiotherapy?
Does anyone know of any studies or MO advice they've gotten regarding use of
Dutasteride
or Finasteride at very early signs of Biochemical Reccurrence (uPSA in the 0.03 - 0.1 range) prior to Salvage Radiotherapy?
jazj
in
Advanced Prostate Cancer
3 months ago
Hashimotos - understanding latest blood test results - any advice for next steps?
index 1.4 (0.3-5.6) She is taking the following daily: 75mcg levo (T4) 6.25mg T3 (tiromel) 200mg spironolactone 4000iu vitamin D 210mg ferrous fumarate 100mg vitamin C and 20mg zinc 1 teaspoon of nigella sativa 50ml aloe Vera juice 1000ug of methylfolate (very recent addition) In addition to 0.5mg
dutasteride
index 1.4 (0.3-5.6) She is taking the following daily: 75mcg levo (T4) 6.25mg T3 (tiromel) 200mg spironolactone 4000iu vitamin D 210mg ferrous fumarate 100mg vitamin C and 20mg zinc 1 teaspoon of nigella sativa 50ml aloe Vera juice 1000ug of methylfolate (very recent addition) In addition to 0.5mg
dutasteride
Ehal89
in
Thyroid UK
4 months ago
PSA Response From Broccoli Sprout Extract (Sulforaphane) May Due To Just Being Moderate ADT
Which will bring me to another topic later regarding early
Dutasteride
/Finasteride use.
Which will bring me to another topic later regarding early
Dutasteride
/Finasteride use.
jazj
in
Advanced Prostate Cancer
3 months ago
How Long To Discontinue 5-ARIs and/or Select Supplements to "Unmask" PSA?
I believe the general rule of thumb is on 5-ARIs like Avodart (
Dutasteride
) you are supposed to double the PSA reading to get the "real" PSA?
I believe the general rule of thumb is on 5-ARIs like Avodart (
Dutasteride
) you are supposed to double the PSA reading to get the "real" PSA?
jazj
in
Advanced Prostate Cancer
15 hours ago
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