Trial on the definitive treatment

[Northcaptain]

This trial is open, although i'm not M1 yet i would like to get the group's opinion on this approach ?

clinicaltrials.gov/ct2/show...

[Tall_Allen]

If you're not M1, why aren't you looking at curative therapies?

[Northcaptain in reply to Tall_Allen]

Hi Allen because it seems that whatever the grading T2 or T3, if an RP surgeon want to remove everything including nervers and lymph in case of ... so why not consider the situation and hit hard ?

[Tall_Allen in reply to Northcaptain]

It depends what you mean by "hit hard." In fact, brachy boost therapy has a better record of success than RP for high risk men. It's because cutting depends on what you cut, which is often inadequate. Let's talk about you instead of some hypothetical man with M1. If you wait until you are M1, you will be incurable.

[Northcaptain in reply to Tall_Allen]

Hi Allen sorry my french-english is playing tricks on me, i didn't understand correctly your first intervention. You said: If you're not M1, why aren't you looking at curative therapies?

So why am i not looking at curative therapies, because i only talked to surgeons until now and the urologist that i've seen is not an oncologist. I haven't seen an oncologist yet to discuss treatment, i'm searching for one. Brachi boost seems ok but thereafter the prostate is not removable i've read. It seems to me that if the disease is confined to the prostate, why not remove it ?

[Tall_Allen in reply to Northcaptain]

Because with high risk PC, it is usually NOT confined to the prostate. If you want to see what your odds are fill this in:

mskcc.org/nomograms/prostat...

It is true that surgery after radiation is not a good idea, but there are lots of better salvage therapies:

pcnrv.blogspot.com/2017/09/...

More to the point, with cure rates of 85% or more for brachy boost therapy, why even worry about salvage?

[Northcaptain in reply to Tall_Allen]

Hit hard i meant the procedure on trial that goes for Docetaxel prior to remove the prostate. Most of the people see there PSA goes down and so we might expect many undectable free running cancer cell to be wiped at the same time. Its only a few 3 weeks cycle, so i could use it right now and have the prostate removed by March.

[Tall_Allen in reply to Northcaptain]

But you have to have distant metastases first. Chemo does nothing but add toxicity if there are no metastases:

europeanurology.com/article...

[Northcaptain in reply to Tall_Allen]

Thanks so much i learned more in 48 hours than so much week reading whatever research.

[j-o-h-n in reply to Northcaptain]

Listen to Tall_Allen he really knows is stuff. BTW where are you located and where and by whom are you being treated by right now? Merci beaucoup.

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 12/17/2018 7:15 PM EST

[Northcaptain in reply to j-o-h-n]

Hi John I'm in Quebec city, province of Quebec,Canada. On public healthcare... but all my MRI are done private because they are short notice and have the best (Tesla3). I'm awaiting meeting with oncologist on dec 27 to discuss options. For the moment I have only seen genetic urologist not specialized in Pca.

cheers!

[HopingForTheBest1 in reply to Northcaptain]

Instead of having started right away with a round of docetaxel, at the initial suggestion of my Oncologist when I was first diagnosed, my research showed that I would possibly do better by using Zytiga with Prednisone and Eligard without the side effects of chemo. After discussing with Oncologist, he agreed, and after 5 months so far so good. Also had robotic prostectomy 1 month ago as part of SIMCAP clinical trial. Hitting it hard.