Had RP in 2006. PSA in 2007 was 0.03. PSA in 2017 was 0.152. Now at 0.698
My Urologist says I should do nothing because of elapsed time, doubling time and present PSA level. He says some cells probably have metastasized already. He feels it will never become a problem in my lifetime( I'm 75).
My RO says I have an 84% cure rate with 6 mos. ADT and 8 weeks Radiation. He feels cells are localized in the fossa. Thoughts?
They are both right. Although I would qualify what your urologist said - you probably won't die from it, but growing metastases may be a problem. They may cause pain, fractures and spinal compression. So watchful waiting (systemic therapy to treat symptoms when they arise) or salvage radiation are both reasonable options. The question is - what do YOU want to do?
Probably leaning towards the radiation. At least I got a shot at getting rid of the damn thing. Just a little worried about any permanent damage from the radiation
Have you any idea why Ferrotran never made mainstream MRI contrast agent? Used effectively in Nijmegen I understand. It's finely divided nano particles of iron oxide. Seems a very good idea to me. Better than Gadolinium contrast agents. Identify those LNMs early...
The iron oxide nanoparticle (USPIO) they use at Radboud in Nijmegen called Combidex (ferumoxtran-10). My understanding is that they hold the patent and still use it there. Other USPIO formulations have not been successful.
You have a doubling time of 1.8 years. Therefore your PSA value could make you nervous in a few years. I would get the radiation and live without ADT in the coming years.
psma scan to get some intel?
Had the Axumin scan. As I suspected it didn’t show anything.
Add a Medical Oncologist to your Medical Team.
Same trip here. RRP in 1996. Recurrence in 2005. PSA slowly climbing, last was 0.58. Axumin negative. Wait? Treat? How, and why?
Tall Allen: I'm not getting this, and it's possible that Tied isn't either. "Localized in fossa?" Which fossa? Is this based on a scan? If he is in fact metastatic, how is it possible that there is an 84% cure rate? And how does such a precise number derive?
Had salvage radiation no side effects ,was not that bad just holding a full bladder can be hard> had a psa of 0.14 now 0.04 hope it stays put for a while... about 2years now good luck
Did you have ADT along with the radiation?
NO Radiation oncologist > felt no need as of now had glesson 3+4 one small positive margin at apical> took 6 years to reach 0.14 what was your glesson #
3+3
I think they are both right, but I think you should get a lot more information about the long term side effects of the radiation and ADT treatments. The RO "thinks" he knows where cancerous cells are, but he doesn't "know" that's where they are. I declined a similar recommendation for radiation "down there" and ADT in 2015 after my 2012 prostatectomy, but I wasn't willing to risk the likely effects of radiation and ADT for the chance that it might be a cure. Six years later my PSA has slowly risen to 0.6 with no treatment, except good diet, exercise, stress reduction, and some supplements. I've also participated in some trials and studies to get the latest radio tracer scans, and no cancer has shown up yet. If/when the ever-improving scans locate one or more tumors, I'll seek localized treatment (radiation or surgery) to get them. Meanwhile, I am having many years of great quality of life, uncompromised by debilitating effects of radiation and ADT.
Suggest care and caution with radiation. I had an L3 lesion treated by SBRT which led to a compression fracture and quite a lot of pain. Now being relieved by acupuncture. I also had pelvic salvage radiation which resulted in serious bowel adhesions and then major bowel surgery to relieve two serious strictures. On the positive side, my PSA is undetectable due in large measure to the radiation therapy, chemo and ADT so its a balance. I'm not suggesting not to proceed with radiation, just to get fully informed as to the risks that apply to the treatment being proposed for you. All the best.
Quit your job and then "Buy low, Sell high".........
Good Luck, Good Health and Good Humor.
j-o-h-n Friday 09/03/2021 7:50 PM DST
I had prostate removed 2002 and five years after that PSA came back and started going up ever since . Till 2020 it was going slowly and than I had COVID-19 and since than things started going nuts. From 12 it went to 25 than to 45 than to 79 and now it is 109 . I have never taken any meds or treatments . Just had PET PSMA scan done and things are not good . All along my doctor kept saying don't worry there is nothing . Well mow I am very worried !!! Waiting on the doctors to say what is the next step .
PSA rising
PSA Rising
Psa rising 
Apalutamide and rising PSA 
PSA Rising
