Met with our MO this week to discuss my Guardant results and determine path forward after Jevtana failed. My last Choline PET scan showed a large area on my left femur that we treated with radiation. Through all this my PSA has risen from 14 to 20.
So on Friday I started my first infusion of Keytruda, I have a tumor burden or 34.2% which my MO said is one of the highest he’s seen. So it seems it will take 3-5 infusions to see if it’s working so the wait and see has started. I feel good about the treatment and hope for good results.
Written by
Jackpine
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I am one of your many followers, and read your latest post. Sounds like Keytruda is a viable option for you. Wishing you much luck and look forward to your future updates.
I have been waiting to start a trial that combines Keytruda with Enzalutamide and Actinium. Unfortunately, a global shortage of Actinium has put things on hold. Unless it opens up soon, I will need to move on and am considering my next option of using both Carboplatin and Cabazitaxl.
I am somewhat discouraged by your experience with 9 rounds of Jevtana. I definitely understand that what doesn't work for someone doesn't mean it won't work for me.
My particular cancer for some reason seems to mutate around most treats like chemo, LU177 and radiation both of which I’ve failed multiple times. In August I will be celebrating 6 yrs. at stage 4, and I still have a high QOL.
Not privy to many things and far from minimal knowledge, but could "outside the box" be a direction possibly taken??? I think Keytruda is one component used. Back in 2015 @ GL10 and as far as scanning no mets yet I accepted Dr. O's offer of Keytruda + Opdivo + Yervoy Immuno injection. Sorry to intrude if offended and ask for reply deletion if desired. Good Luck.
Dr. Onik was a "stand alone" provider at that time but had been associated with Celebration in Orlando and elsewhere in early years. His cancer involvement dates back to early 1980's and began PCa in late '80's with procedure innovations and equipment inventions.
The offer to use his mixture followed his success on others and I was a "ONE OFF" experiment at the time having my diagnosis. I chose a Quality of Life (minimal side effects)direction over SOC to see if it might work. 71st birthday was Saturday and bicycled 115 miles. Short of my goal but I had a bike crash one week ago and am still hurting.
I recommend checking for mutations at least yearly (others may have more information). Ut my first Guardant test show low MSI and only the PICK3A mutation. Now I have multiple mutations and a very high MSI.
I will continue to post on how I’m responding to Keytruda. From what I’ve read it’s been able to put some men into remission. I’m sure research will show that immunotherapy can be improved to reduce possible side effects.
My husband is one of the lucky ones, 2 treatments of Keytruda and 2 years later psa still undetectable. I am over the moon happy for you!!!! Such wonderful news I'm praying for you and can't wait to read your success story
It stands for tumor mutational burden and is a measure of tumor mutations in the DNA string. A higher number typically responds well to certain types of immunotherapy.
A friend of mine who has throat cancer has been in remission for some time responding to Keytruda.I went to see his oncologist ( not a very friendly guy ) and asked if Keytruda is for me/ He said a flat NO. Now I see this having some success with prostate cancer. What is the individual common items that will be successful doing Keytruda? Was he just an ignorant .......?
I just saw my doctor at UMass and asked about keytruda for metastatic prostate cancer. She said it wasn’t in use yet but in trials. I’d certainly like to try it!
I’m not in a clinical trial but my tumor mutation burden was 32% which made me a candidate I believe to try it. I don’t have many choices available at this time so I’m happy to give it a go!
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