my husband has frequent urination at night and his doctor prescribed Silodosin 8mg. It hasn’t made much of a difference, so now he wants to add mybetriq 25mg. There is no generic and it’s $262/mo. That is with his Part D plan. Has anyone used this medication and did it help? Did you have any side effects? Or are you taking another medication (preferably generic) that has helped. He would be taking both of them. Thanks.
Frequent urination at night - Advanced Prostate...
Frequent urination at night
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Jewelrylady
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My husband has the same issue and did try Mybetriq 25mg and then 50mg and neither helped much. He also tried Flomax prior to that with the same result. Now on Avodart which also isn't helping but at least it's supposed to positively impact the PC.
In the meantime I've heard that amlodipine, which he's taken for years for high blood pressure, can cause or exacerbate the issue. So the GP has said he can try a half dose (or maybe cut it out altogether as he may not need it any more) and see if that helps. We're going to try that when we're able to get his BP tested regularly.
you can test your bp anytime you want and quite accurately at home nowadays. Get the new style cuff that is rigid in the back “ about 60% of the diameter of your arm “ . They are way more comfortable during inflation. The Omron machines like the m3 series are under or around $100 …. Very accurate to the point they can even do “ sets of 3 “ averaging and work to blue tooth apps that take Kardia home ekg and Bg machines all on one app. Just fyi OMHO.
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Thanks, we may try that. I've had no luck getting him to stop by the fire station, haha.
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Thank you. His blood pressure is good when he goes to doctor appointments and we have a BP cuff and it’s normal. It’s so frustrating trying all these meds and having nothing work. He doesn’t drink anything a couple hours before bed.
a lot of us endure frequent urination , even at night. Weve had some great talks about it on the group. In addition to your answers here , you can probably use the search tool at the top of the page to see those conversations, most are about coping without additional drugs or drug modifications.
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Thank you. Thats a great idea. What should I write in search? Frequent urination or ?
Well ….. went and looked but not sure it worked like I expected . Basically we’ve talked a lot about dealing with nighttime urinations by keeping vessels next to the bed and using those and not having to get up at all. Many of us keep jugs next to the bed at night, I use those tight lidded quart Florida orange juice jugs. I keep several …. when I have to go, I roll over and uncap a jug …. Finish up and recap it. After a while, you can do it automatically never having to actually wake up to pee. Next day or a couple days later ( depending upon how many jugs and how fast you fill them ) , empty jugs into toilet , rinse them out in bathtub , squirt a hefty amount of isopropyl alcohol in them to keep them sanitary, use them again. No worries with drug interactions or SEs .. quick quiet effortless comfort.
I’m partially in a wheel chair, so jumping up to go across the hall is a big deal for me. Additionally, I sleep in a waterbed, which I can barely get out of at night or anytime. Containers by the bedside solves everything. Definitely no $262 a month. lol I use mine up to 4-5 times a night.
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I find it a real pain to have to pee from 3 to 8 times a night but would never even think of adding another marginally effective drug to try to fix that. Get a decent urinal and pee when you need to. I just used my husband's Oura ring to monitor my sleep and i found out that I am actually sleeping OK in spite of waking up frequently to pee and with hot flashes and with pain. I am tired a lot during the day but it might be more from just being a *!ch$#up mess from the cancer and the drugs. I might actually be gettin OK sleep in spite of all this.
Don't take other BS expensive drugs if you can avoid them.
Yea I agree. I sleep on a cpap every night and waking to “ go “ semi asleep doesn’t change my quality of sleep at all. We sure “ don need no more stink'in badges…. ur …drugs “ . Those screw top, crooked neck “ urine containers “ ( type urine containers on Amazon) also work great beside the bed at night and no spills with the top and neck design.
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i looked at amazon. screw top is critical for me. i spilled the nic stainless steel open top one a couple of times. what i have now is a little stainless "growler" with a very tight screw top. the only down side is that the opening is only about an inch so you have to aim carefully but i have never missed so far.
Besides the OJ jugs, I too have the crooked neck , screw top, jugs from Amazon. That handy handle hooks on things ( rung of dining room chair or basket on my mobility cart ) . Mine are plastic. They can be “ life savers “ so to speak, when you need one desperately. With all the shrivelage and shrinkage down there , if I’m in a big hurry…. what ( very ) little that is left fits in there easily , tidy up after with a moist towel. We haven’t had a laughing session about shrivelage and shrinkage and mink lined tweezers in a long time. Maybe its time for another fun thread about that topic. 😂😂😂
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Have you tried a Paralogic Catheter? Basically like a condom that you clip a bag to.
we can only wish rotflol. Shrivel and shrinkage kinda make that impossible on me. I love one of those to work for me, especially when driving.
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They come in different sizes. The first one I ordered was small so a bit more research and ordered the right size, they have a sticky surface on the inside so that it won't come off. I wear a clamp pretty much 24 hrs a day, the one I'm using is made in Canada
that actually sounds intriguing, think I’ll order one and give it a try for when I’m out about driving or on my etrike. Thanks for the info, the sticky surface part makes it look potentially useful. I’m good around the house but I need better usefulness when away.
Thanks
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The correct expression is Nocturia.
Many of us suffer from it after Hormone therapy and Radiotherapy for PCa but hopefully after a few (sometimes several) months it will settle down back to normal.
My timeline last night for instance was bed at 11pm, wake up at 12:30am, get up and dribble, and so on every 1-2 hours until I get up at 6am, this is pretty typical.
My RT finished 5 weeks ago so still hopeful it will soon get better. I have my last drink at 6pm, it helps.
It makes you feel pretty wiped out as we maybe only complete the odd full sleep cycle, these are essential for overall health. We should be completing about 4-6 full sleep cycles each night, but with nocturia we don't get close to that.
I have moved to the spare room which fortunately has an en-suite to save disturbing my wife too much.
The medical profession accepts this is a common side effect of RT but unfortunately doesn't have much in the way of reliable treatments.
If you find something that works I would be very interested to know, good luck.
I will definitely post again if he finds something that works! He decided he will try the Mybetriq and he got it for $211. Woohoo!
Not sure my experience will translate to yours but I had an enlarged prostate many years ago and suffered with BPH. I got up at least 3-4 times a night. My Urologist tried me on a couple of alpha-blockers but the side effects were lousy. The third alpha-blocker we tried was Alfuzosin and it worked well with no noticeable side effects. I probably used it nightly for at least six years. It relaxes things down there and was not expensive.
Thanks. He was on alfuzosin and had to double the dose, but after his SBRT it stopped working and doctor switched to silodosin. And now that’s not working! He had total knee replacement 5 weeks ago so maybe the meds he was on for that is causing the problem. Glad to hear things got better for you.
I had knee replacement quite a while ago and I can confirm that the drugs made me have to urinate frequently throughout the night. I did return to relatively normal frequency after 2-3 months.
I've been taking one 20mg Trospium (generic for Sanctura) at night for 4 yrs. It worked great for 4 yrs but my last batch came from a different manufacturer (originally AVET but now GLENMARK). Now I'm getting some minor side effects from it for the first time. Not sure if it's the new manufacturer and some inactive ingredient? I still recommend it over Mybetriq, though its been around longer. I'm also taking 0.8mg Tamsulosin and that combo keeps things comfortable for me for the most part. And pretty much covered by Medicare.
I find the Trospium helpful, too.
I am taking 50mg of Myrberiq and it has help quite a bit. I used to get up 5 to 6 times a night and now I usually only get up 2 times a night, occasionally 3 times if I indulge in a beer with dinner. You have to take Myrberiq for a couple of weeks before it really starts working. No noticeable side effects BTW.
He decided to try it so I hope he’ll have similar results as you 🤞
Have you seen Peter Attia MD video "Is your nocturnal urinary frequency normal? | Peter Attia & Ted Schaeffer" wearing compression socks has worked wonders for me. Hope it helps.
I live in South Australia. I have the same problem but have been able to cut back to 2-3 times a night. One GP put me onto Solicare (Solifenacin Succinate 10mg). Then another GP told me to take 1/2 Betmiga (Mirabegron 25mg) with 1/2 Solicare each afternoon. This has helped me considerably. Betmiga costs me A$66.95 for 30 tabs (so I get 60 tabs when cut in half)but I get back about $40 from my private health. Solicare costs me A$27.95 for 30 tabs. I don’t get anything back from Bupa with this. Not a full solution to my peeing, but may help others too. Another thing I do is have a plastic peeing bottle next to my bed, which saves walking to ensuite. One step, I am up, then pee and back to sleep almost straight away.
try bladder training also try Prelief and Claritin 10 mg seems to to help me i have tried everything for 17 years no side effects only watch calcium intake.
I’m sorry to hear of his troubles, but unfortunately it is a chronic, somewhat insoluble issue for many of us as you can see.
One important consideration is how much urine he can comfortably hold. I have tried just about every drug, settling on Trospium 60mg daily. It works as well as Mybetriq for me and it’s cheap.
However, because I’m so habituated to wake every hour or so, nothing really changes it. I don’t like the feeling of even a slightly filled bladder anymore, so I have to get up just as frequently, even if I’m not producing much volume.
If he is producing considerable volume with each trip, restricting fluids later in the day can really help. If not, and none of the drugs seem to make a difference, it becomes a matter of how much he’s sleeping at a time, how far he has to go to pee and how easily he can get back to sleep.
I work on all three, and for me getting 90 minutes or more of sleep at a time is crucial, since 90-100 minutes is the length of sleep cycles. Everyone-everyone-wakes up approximately that often every night, but of course the average person goes right back to sleep without stirring enough to realize it.
If I can get intervals of 90 min to 2 hours my issue is inconvenient but quite manageable, as I am skilled/lucky at going back to sleep.
But if the intervals are shorter, say 45 minutes to an hour, it’s impossible for me to get proper rest. Sleep aids of any kind either don’t help enough or aren’t worth the side effects and/or tolerance. I do best with lots of exercise, fluid restriction late in the day, and the trospium.
The tricky part of that drug and most others for the purpose (including Mybetriq) is they can induce comstipation, which is countered in part by exercise, a good diet but also hydration-a catch 22.
Again, try to consider if how much he’s getting up is due to actually producing that much urine at night. It could be that he’s now just in the habit of waking up, or simply can’t hold much comfortably anymore. This is important to know as you pursue answers. Also be sure to rule out any apnea or other common sleep issues. Great luck to you!
"... now he wants to add mybetriq 25mg. There is no generic and it’s $262/mo. That is with his Part D plan. Has anyone used this medication and did it help? Did you have any side effects?"
I took, and it helped, with no side effects. I took it for a few months, three years ago, when I was having MRI, biopsy and radiation. I was mainly concerned with daytime urgency. But it was not that important to me and I disliked having my insurance pay $600/month for a pee drug, so I stopped it.
what has really helped my husband is elevating his legs for awhile in the afternoon. This helps the fluid that has accumulated in his lower extremities get urinated out before he goes to bed. We found this trick by reading about nocturia. He is on Oxybutin, which seems to help.
Hello, I was on Oxybutynin about 1/2 way through my 44 IMRT treatments. That and Terazosin had me very comfortable and the flow felt great. Not 30 yr old great but felt awesome for a change. Took me off it a few months later and only on 1mg of Terazosin. Probably should do twice a day but trying to limit meds. Just turned 70 and that’s all I’m on. I do wake up at least twice a night and it seams the mornings are 2-3 times before going of to work, probably from water/coffee intake. I do leak/spot while sleeping on occasion. Humiliating this getting old stuff. All we can do is all we can do!
Hi / What you need a protection during the night and then look at this adress may it helps you.
youtube.com/results?search_...
Looking for help for those of us who have no prostate and have undergone radiation. These videos seem addressed to different situations. Currently undergoing pelvic floor training with a physical therapist. So far, no improvement. I get up 2-6 times a night. Thanks.
Try the legs elevating during the day It has really helped my husband Or wear compression socks
both
I took saladosin and it worked for me. However before that I was on flomax then and did not work. But maybe that will work for you
Drink less water before sleep and try supplement Grape Seed.
A caution about less water …. If you are on opiate pain management and using laxitives to balance the constipation that brings, keeping an even water / liquid intake is important to prevent bowel plugs / obstructions. Cutting down all night and before might create a dangerous bowel obstruction problem. This is strictly IMHO, always check with your palliative care team first for anything / everything like this.
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I take a quarter gummy bear at night that doesn’t stop having to get up four times due to hot flashes. But it makes it easier to go back to sleep quickly. I use something called “lights out “
Suggest your goal be 3 trips over 6 hours, and at 8 hours up and at em ? More than that, and start a program to restrict liquids x hours before bed?
All Day Chemist sells Mirago 50 mg for $1/pill. Generic is Mirabegron. I've used it for many years. Works some, not a total solution for me.
I also was up 3-4 times a night , I then tried sleeping without underwear and now get up once. It seems kind of obvious now, wish I had thought of it sooner. JJ
I was getting up every second hour to urinate. It did not seem to matter what I drank in the afternoon. If I drank less I just peed less, but still had to go to the bathroom. I also have high blood pressure and an artificial sphincter and blaimed it on those.
I also have sleep apnea and stopped breathing up to 50 times/hr. The hospital gave me a CPAP machine and since I started using that I rarely have to get up at all. Feel refreshed and no need for an afternoon nap anymore.
Hello, sorry to hear the trouble your husband is having fighting Nocturia. I too had RT 38 sessions and this was back in 2018. The frequent urination is what finally made me go to see an urologist, six years later I still have to go to the restroom 4 to 5 times every night. MO put me on Flomax which to me made the Nocturia worsen. As many others have said adding another pill to my already full stash of drugs isn't appealing to me. I bought a plastic portable urinal that I keep near my bed and it has been very helpful. By now I am used to not getting more that five hours of sleep for a long time.
Tried everything for years. Finally was in rehab center for broken hip rehap and had to use a urinal while bed ridden. EUREKA!!! Why was i not doing this all those years. Get some checp urinals with covers and put next to bed. Just be a little careful till you get the hang of it (very easy) and your life will change!👍😜. Good luck.
Frequent night time urination is bothersome. In my, now 9 years after G9, have discovered that stopping fluid intake three hours B4 bed and fully voiding helps. The biggest help has been compression socks for the day.
After my radical prostectomy in 2021 I engaged a physical therapist who worked with me for several months regarding doing kegel and other exercise variations- I reduced to one visit per night by about the 5 month. I'm holding steady but I still do kegels 3 times a week.
Sleep wearing two depends (double up)..... and you'll piss all you want without knowing, feeling it.... change in the morning.....(waterproof mat on top of mattress just in case you're lucky and have a very wet dream)....
Good Luck, Good Health and Good Humor.
j-o-h-n
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