Is Graviola (Soursop) Fruit Extract A Heavy Weight Fighter Against Prostate Cancer Cells?

[back2health]

There are loads of information on numerous websites about the Graviola fruit, also referred to as Soursop, being a very powerful cancer cell fighter/destroyer. Has anyone any information about or experience using it for prostate health?

[timotur]

It’s anecdotal, but there’s a 92 yo Filipino man at my local McDonald’s who swears he beat Stg IV PC drinking Soursop tea and going vegan, among other things, like smoothies with coconut oil, spinach, orange, and banana.

[cesces in reply to timotur]

You can find a variety of such treatments at:Quack watch.com

[timotur in reply to cesces]

quackwatch.org/cases/fdawar...

[cesces in reply to timotur]

Meets the "LOW AND BEHOLD" standard of statistically validated results. LoL

“Prostate and Bladder Cancer…I was diagnosed with prostate and bladder cancer…I chose to bypass surgery and started my own research to find alternate treatment. In my search I found an article that explained the effects of sour sop on cancer cells. I started a daily regiment [sic] of sour sop about two years and low and behold the mass has been steadily shrinking.”

[back2health in reply to cesces]

Great--glad to hear that, for you and everyone else who could benefit from this medicinal fruit plant!

May I ask, how were you taking it-- raw fruit juice, or in extract capsules? If extract capsules, what amount?

[Bythetree in reply to cesces]

Hello Cesces, hope you feeling well.I started soursop1 month ago.

Glad to know that it takes many months of regular use for soursop to work, as per your post.

Did you have RT or what treatments.

I have 3+4=7 Gleason Score, and recent mri, shows no spread,as per PSMA 9 months ago.PSA remains at 3.5 for 14months.Was at 4.7 when diagnosed 17 months,but went down some after starting a vegan diet.

But have chose IRE as treatment(talking to radiologist soon. It was recommended by my Decipher's score to do hormone theraphy.I do not want ADT, side effects,and is trying to get some oestragel .

I am thinking since soursop takes many months to work I can continue it with oestragel ,and the IRE.

Sorry to unload all of that on you but would appreciate your opinion on any part above

[back2health in reply to Bythetree]

It can't be any kind of Graviola supplement. It needs to be the concentrated extract, the same form used in research studies to expect similar results. Better yet, a "concentrated standardized extract" will be best because it has the highest levels of the active phyto- compounds from the fruit and other parts needed for the best results. And those compounds are called Acetogenins.

[back2health]

Thanks for the reply. I realize the fruit, like they all, have nutritional and therapeutic value. But from I've been reading from a number of sources, the concentrated extracts of the fruit have shown impressive cell-protective and restoration benefits for numerous diseases, including cancer.

[Graham49]

There are studies showing anti PCa properties of Graviola but they all seem to be in-vitro studies. The study below is for leaves and bark extract.

Research article

Open Access

Published: 10 December 2020

Selective cytotoxic and anti-metastatic activity in DU-145 prostate cancer cells induced by Annona muricata L. bark extract and phytochemical, annonacin

Kimberley Foster, Omolola Oyenihi, Sunelle Rademan, Joseph Erhabor, Motlalepula Matsabisa, James Barker, Moses K. Langat, Amy Kendal-Smith, Helen Asemota & Rupika Delgoda

BMC Complementary Medicine and Therapies volume 20, Article number: 375 (2020) Cite this article

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Abstract

Background

Annona muricata L. was identified as a popular medicinal plant in treatment regimens among cancer patients in Jamaica by a previously conducted structured questionnaire. Ethnomedically used plant parts, were examined in this study against human prostate cancer cells for the first time and mechanisms of action elucidated for the most potent of them, along with the active phytochemical, annonacin.

Methods

Nine extracts of varying polarity from the leaves and bark of A. muricata were assessed initially for cytotoxicity using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) assay on PC-3 prostate cancer cells and the ethyl acetate bark (EAB) extract was identified as the most potent. EAB extract was then standardized for annonacin content using High-performance Liquid Chromatography - Mass Spectrometry (HPLC-MS) and shown to be effective against a second prostate cancer cell line (DU-145) also. The mode of cell death in DU-145 cells were assessed via several apoptotic assays including induction of increased reactive oxygen species (ROS) production, reduction of mitochondrial membrane potential, activation of caspases and annexin V externalization combined with morphological observations using confocal microscopy. In addition, the potential to prevent metastasis was examined via inhibition of cell migration, vascular endothelial growth factor (VEGF) and angiogenesis using the chorioallantoic membrane assay (CAM).

Results

Annonacin and EAB extract displayed selective and potent cytotoxicity against the DU-145 prostate carcinoma cells with IC50 values of 0.1 ± 0.07 μM and 55.501 ± 0.55 μg/mL respectively, without impacting RWPE-1 normal prostate cells, in stark contrast to chemotherapeutic docetaxel which lacked such selectivity. Docetaxel’s impact on the cancerous DU-145 was improved by 50% when used in combination with EAB extract. Insignificant levels of intracellular ROS content, depolarization of mitochondrial membrane, Caspase 3/7 activation, annexin V content, along with stained morphological evaluations, pointed to a non-apoptotic mode of cell death. The extract at 50 μg/mL deterred cell migration in the wound-healing assay, while inhibition of angiogenesis was displayed in the CAM and VEGF inhibition assays for both EAB (100 μg /mL) and annonacin (0.5 μM).

Conclusions

Taken together, the standardized EAB extract and annonacin appear to induce selective and potent cell death via a necrotic pathway in DU-145 cells, while also preventing cell migration and angiogenesis, which warrant further examinations for mechanistic insights and validity in-vivo.

[back2health in reply to Graham49]

Thanks Graham for this informative research study. The fruit looks quite promising! Insightful finding out about the main active component "annonacin."

[monte1111]

I can't even get past mango.