Cut in dexamethasone

[Cynthgob]

Husband has been on prednisone and then dexamethasone along with Zytiga for 2 years and 8 months. My worry is his adrenal glands won’t function as we are having to wean him off the dex due to water retention. Any thoughts? Dex has been 9 months. Stopping zytiga as well for now.

[Tall_Allen]

He has been taking too much Dex, and has to be weaned slowly. Why would his adrenals not function?

[Cynthgob in reply to Tall_Allen]

I had read that the steroids eventually kill off the adrenal glands. They r slow to return to functional and a lot of times they don’t return. Need to stay on steroid of some type.

[Tall_Allen in reply to Cynthgob]

Just take it as it comes. Wean him off first and then see if his adrenal function returns.

[Cynthgob in reply to Tall_Allen]

But he needs to function this summer. . Time is something we don’t have

[Tall_Allen in reply to Cynthgob]

What is your choice?

[elvismlv123 in reply to Tall_Allen]

I have taken proscar or finasteride since 2004. It suppresses DHT and DHEA. My adrenals function ok. It could be an alternative to Zytiga

[elvismlv123]

It doesnt work that way for finasteride or testosterone...so I dont believe it does that to the adrenal gland. I am not sure but I think the adrenals produce DHEA.