This is about my Father, he was on Nubeqa and Eligard shot for last two years. His PSA started going up again and his pains also started. His medical oncologist changed his Oral drug to Zytiga with prednisone.
He is told not to eat anything two hours before and one hour after Zytiga.
And usually prednisone is taken after a meal.
So should he take Zytiga and take a break of one hour and then have prednisone after the meal?
I just want to know how usually others are taking Zytiga with Prednisone?
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Szdnizam3
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I typically take my Abiraterone (generic Zytiga) when I get up at night to urinate, usually between 1:00 and 3:00 AM. I take the prednisone shortly after I wake up around 6 AM with a little food.
I just take my 1000mg of abiraterone and 5mg of prednisone at the same time when I get out of bed, or sometimes a little earlier when I wake up. I wait an hour to eat anything other than black coffee. I have responded well to this therapy with nothing other than the usual side effects.
Let me point out for those who have not been at this long, I am at year 26!
EVERYTHING WE DO DURING THE LAST STAGE IS EXPERIMENTAL! THERE JUST IS JUST NOT ENOUGH TIME OR CASES TO BE ABLE TO CHART A SINGLE PATH FORWARD, thus we are ALL GUINEA PIGS, but that is life.
I SCREAM FROM THE RAFTERS TO LIVE LARGE WITH THE TIME YOU HAVE LEFT!
Make up a bucket list and get at it, live your life with pc and DO NOT LET IT CONTROL YOUR LIFE!
Yes I will write more about it soon as I just started to fail last November but am now in serious trouble as websites to long to switch drugs! But oh well 26 years is still a record so no regrets, sone 43 rounds of IHT combo !!!
Yes I am the impossible but it is true! I have now failed and because our system did not react quickly, my cancer has taken off big time do a bad situation for me but such is life in this nightmare!
Tks but such is life. I got 26 years while my two closest pals only got 6 and 7. Further, I feel for the young people who get serious cases of cancer but have not had time to live life etc
Exactly, I have given much of myself to help the cause since day one as not a day goes by when I do not think of my two best pals who both died ugly painful ends after only a few years.
I push hard yo stay here in there memory and honour! Stay well as the wsr hies inside and outside of us to get this disease made chronic!
Much of the answer depends on your dad's sleeping and waking habits. I tend to be a night owl, and I may have a late-night snack around midnight. I've gotten into the cycle of taking my Abiraterone at 10 am . . . shortly after I wake up. Most people would wake up and, as a result, take the Abiraterone earlier. But that general schedule--eating, sleeping, waking up, and taking Abiraterone certainly meets the requirement of no food for two hours before the medicine.
Then I have to wait, at least technically, an hour before eating. I'll have a cup of coffee an hour or so after taking the Abiraterone . . . though I doubt that even counts as food. I actually don't eat until about two hours after getting up.
As for the prednisone, my oncologist didn't specify a time of day . . . just that it should be on a full stomach. So I'll take the prednisone after I've eaten dinner.
been on Abiraterone and prednisone for more than two years.. i take it early morning at 5-5:30 and I cannot eat Breakfast until 2 hrs after. (Must be on an empty stomach).prednisone is after bfst at about 8 am.
Early morning before breakfast is my routine, too. Zytiga's website says "Take ZYTIGA® tablets as a single dose one time a day on an empty stomach. Do not eat food 2 hours before and 1 hour after taking ZYTIGA®." I take the Prednisone after breakfast.
Watch out. He shouldn't be taking full dose zytiga (1000 mg) with meals. That's potentially overdose since fat in food will increase uptake. Check with your doctor and follow the advice on the drug info and on this site.
Hi, my husband takes his Zytiga as soon as he gets up in the morning and then waits at least an hour to eat breakfast. He takes his prednisone with dinner.
I (like others who have posted) Take my Zytiga/Abiraterone and Prednisone right after getting up in the morning.
Then after the morning rituals of showering, shaving, and such a good amount of the hour that I have to wait before eating breakfast has elapsed.
I did find that other meds that I normally took in the morning, blood pressure specifically seemed to be less effective if Itook them at the same time as the Zytiga/Abiraterone and Prednisone. After a few trials on timing I was able to find a sweet spot to take the other meds.
I'm off abiraterone (Zytiga) with prednisone for a vacation for the time being. I tried taking it as the label indicates, 1000 mg ( four tablets) fasting with no food after for at least one hour. This gave me an unpleasant upset stomach. It was bad enough that I vomited once, I couldn't hold it down. My doctor changed the treatment to one tablet with food. The recommended food is about 300 calories containing about 7-8 grams fat. I had no gastric discomfort with this and my PSA was undetectable. However, my testosterone though it fell dramatically was still around 40 so my doctor told me to increase the abiraterone to two tablets with food. This reduced my testosterone level to 16-20 range while keeping the PSA undetectable. This was good since I didn't have any upset stomach. It may turn out that studies will prove that a lower testosterone level gives better long term cancer control but so far they have not to my knowledge so this will be the regimen i take when I inevitably go back on treatment.
Of course taking less medication is cheaper but since I can buy the four tablets daily dose for $138/month online cost is not the problem.
I take my Zytiga at 5:00 am and my Prednisone with breakfast usually in the area of 9:00 am been doing this regiment since 2018 so far so good. PSA is 0.1 since I started. Never give up never surrender Leo
U of Chicago , Dr.S , his protocal is for 1-250mg of Zytiga + 5mg taken together after a light breakfast . Been doing this combo coming up to 3 yrs . All good so far .
I've been on that protocol for a year. I take Zytica when I wake then set an hour alarm and take the prednisone in an hour or when I wake up again, after I've had some breakfast. Then I take a second prednisone at 4 pm because it you take it later it can keep you from falling asleep.
It's amazing how hit and miss it all seems, having read everyone's experiences. I bet you wish you had never asked 😏.
There was a study done some years back about the efficacity of Zytiga taken with food and without. The idea is based on absorption, a lesser amount Zytiga taken with food, or Zytiga taken with water.
I take mine 500 mg with breakfast every day, the prednisone I take about an hour earlier.
I've been working on the absorption method. But remember we are not all the same, our metabolism for example.
At this moment in time, it might be wise to take the medication as prescribed by the doctor, then later on you can start to tweak it, if you feel you need to.
I don't think 1000 mg with food is a good idea. It might be over load.
My husband has been taking Zytiga (abiraterone) and prednisone for around 8 months. When he gets up in the morning he takes the Zytiga (4 tablets) before his coffee. Then later after eating something he takes his prednisone. With that he also takes calcium with vitamin D, Vitamin K and Magnesium. So far he’s been responding well to the hormones. He also has an Eligard injection every 3 months. He’s been PSA undetectable since March after his 28 IMRT radiation treatments and continued ADT and ARPI.
Aberiterone is now off patent and there is an alternative product called Yonsa Mpred which as the name suggests includes prednisone, so the idea is to take the prednisone in conjunction with the aberiterone. More importantly, the daily dose provides only half the amount of abiterone compared to Zytiga. The manufacturer claims they use a micro fined aberiterone which is absorbed more readily. It is suggested it be taken with a meal. Trials have shown that the level of aberiterone in the body are similar between Zytiga and Yonsa when used at the manufacturer’s full dose.
Yonsa has been approved by the FDA and approved in Australia from 1 August 2024. I live in New Zealand and it is not approved here yet. It’s big appeal is that it is about one third the cost of Zytiga when both are used at the manufacturer’s full dose. I can’t get funding for aberiterone until my primary ADT ( goserellin ) fails.
My husband takes 250 mg Zytiga and 5 mg of prednisone every morning with food. His oncologist who is medical director of cancer research and oncologist specializing in prostate cancer at CU Health reported to us that 250 mg of Zytiga WITH food is comparable to 1000 mg on empty stomach. So far he has been doing this since April and all is good. I wish your father the very best.
Yes, I am planning to reduce the dose of my AA soon..I will have 250mg Zytiga and pred 5mg with low fat food in the morning to save cost, hope this will work for me. The small research in India has been done with hundreds of sample as well as some Oncologies that the low dose of AA with food showing the result is better than the presribed dose
I have been on both for about a month. I take Prednisone with breakfast and one after dinner, I take Abie 4 pills when I go to bed around 10:30 or 11 or 2 hours after a snack around 8 or 9pm. Pharmacist stated that since Abie can make you feel tired after you take it, why not take when you go to bed. makes all the sense to me.
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