Another Update

[Dondodoc]

After stopping Aberaterone for 6 weeks gone to enzalutemide, after 6 weeks blood test psa is <0.1, but side effects horrendous, tiredness lack of energy no appetite not interested in anything! Consultant today reduced dose to two tablets a day for two weeks, if no change after two weeks a holiday taking nothing. Anyone had similar experiences? Don

[Tall_Allen]

You may be better off alternating chemos and advanced hormonals.

[Dondodoc in reply to Tall_Allen]

Thanks T A alternative chemo, deco or something else?Willing to try anything Don

[Tall_Allen in reply to Dondodoc]

docetaxel is fine if you haven't had it. Sometimes it can reverse advanced androgen resistance so that Xtandi works better afterwards.

[Shooter1]

Enzo 160 mg made me a complete invalid. Currently on 80 mg and have been for a couple of years. Tolerable at that dosage. I didn't even ask Drs, just did it after my wife and I discussed it and decided 3 yrs as a living being was better than 10 years as an invalid. Wish you luck with the reduced dosage.

[Proflac]

Really sorry you have these effects. My husband had a similar response to enza. It totally wiped him out and there seemed to be some minor cognitive issues too. And a reduced dose didn't help unfortunately. It seems very variable as some tolerate this well for years. Not sure there is any way of knowing who will have adverse effects, I guess it just has to be tried. We had the option to moving to abiraterone as this had not been tried first. A better experience from the perspective of side effects so far. Still fatigued but nothing like on the enzalutamide. Wish you well.

[MateoBeach in reply to Proflac]

Hope that regimen with Abi works well and long for him. When one day another advanced AR med is called for (perhaps after alternating with a chemo) he might try darolutamide which does not get into the brain. Could be justified due to high grade intolerable SEs from enzalutamide. Hope that is way down the road. Happy thanksgiving.

[Proflac]

Thanks, and thanks for the thanksgiving good wishes, though being a Brit we don't celebrate! I do though have some very happy memories of my husband and I joining a celebration of thanksgiving in Sausalito (SF, CA) back in the late 1970's.

[j-o-h-n in reply to Proflac]

Sausalito.... now you're talking..........(especially in the late 70's)....

Good Luck, Good Health and Good Humor.

j-o-h-n Tuesday 11/24/2020 10:08 PM EST

[Shooter1 in reply to j-o-h-n]

Fun time of life in Calif. before urbonites took over and before Pca. At least when I got back from SEA>

[j-o-h-n in reply to Shooter1]

youtube.com/watch?v=y3KEhWT...(Not working as expected?)

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 11/25/2020 4:57 PM EST