I promised some people a bit of a short outline of experience of 177Lu-167 therapy.
Had 8.1 Gbq yesterday. Administered after saline solution, then half hour of Lu-617 followed by more saline. Throughout was sipping on lemon water to protect salivary glands.
Only side effect so far is mild fatigue.Baseline fbc, eflt psa etc done two days prior. Next infusion in 6 weeks; was to be 8, but on discussing with Dr Wong there is no real therapeutic reason for 8 vs 6 weeks. so ive gone for 6 week interval.
Will know whether there is any significant effect after scans etc following second infusion.
Cheers
Mark
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MarkEmrys
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Thanks Mark. Yes please. Keeping us updated. Mateo Beach is on a similar path. We will learn from our Brothers. EARLY seems more effective, is a recurring theme, on so many of these treatments. Hit it when its weakest. “EXTINCTION VORTEX” is what Paul calls it. Best of luck to you and yours,
I expected ice to cool salivary glands — i guess to reduce blood flow. They do the lemon water sipping to get a protective layer of saliva. Not aware of any proper studies on this.Cheers
Hi I have lots of question on this for anyone to answer?
Lemon water? To get your saliva glands squirting I guess?
We heard in the past about trying to cool saliva glands with ice applied to the skin to prevent damage to them?
Where is the science on this today, around the world? India, Germany, US, etc?
Is LU-177 approved for general use for PC patients in Australia.
In the US it was recently approved for certain PC statuses. What it will actually cost to get that Drug into your body for each treatment with approval of up to six injections? Anyone know?
Drug company will charge hospital or clinic $42,500 for each injection for just the drug. Does facility double drug cost and then add all the charges for medical personel, supplies, room charges, etc etc? Could this cost $90,000 or more for each injection?
Has any US insurance said they will pay for it?
Anyone actually received this in the US outside of trials?
I am looking for similar information. My U of Washington OC has suggested my local Cancer Center reach out and find a facility where a PSMA scan and LU-177 are available after the FDA approval. No luck so far, very little information coming my way. It may be a new round of a different Chemo in the meantime. Good luck on tracking down the needed information.
I think the U of W and the Seattle Cancer Care Alliance we’re going to offer Pluvicto this month until the suspension of production announcement on May 5………who knows how that will affect insurance coverage……..looking to consider another 1-3 rounds of chemo while waiting……… must be off chemo for at least 4 weeks before first Lu-177 treatments.
Thank you for your reply, I will be back in the states on Wednesday and will probably get that bad news. Best of luck, I assume I will be back on the second round of a different Chemo.
Mark - we’re all rooting for you and following your updates. I’m interested in how you ended up here. Could you give a little history- how long have you been in the fray?
Dx m1 oct 2019. Mets to iliac and scapula. Docatexel and fiirmagon upfront followed by ebrt to pelvis and prostate. Abiraterone plus prednisone worked for a year. Then SBRT. Following progression now doing lutetium…
Hi Mark thank your for your LU treatment update interested in your LU journey . I am in Brisbane tried for first line LU treatment but refused by 3 different doctors did not try I-Med Wesley ALL the best with your treatment
Mark thanks for your reply I am interested to know if you have had exposure to chemicals/fumes/ bad dust during your life. As when i was diagnosed 12/2022 told PC was advanced & aggressive and matched with 3% of advanced PC most of whom had Agent Orange or were Farmers or Firemen. I have had exposure to chemicals/fumes /dust
Thank you Mark for keeping us all informed on this new treatment. I am HSPC With mets to lymphs in pelvic and chest and am going for my OC consult at MSK in NYC this week for a phase 1 trial of lu177 and SBRT .I will also post my experience with specifics.
On a new thread as my case is not advanced CRPC, but it is prior to any ADT treatments.
I didn’t qualify for the Lu177 because i had 5 separate tumor locations, 3 was the max in the inclusion criteria. They should have told me before i drove 4 hours to the big city.
I did and it was no. I did read the inclusion exclusion criteria but the administrators said come on down, then when I met with an oncologist he was not the OC on the trial and he thought I was there for a second opinion. When i told him why i was there he looked up the trial criteria and said I don’t qualify but he would check with the trial OC. This same thing happened when I wanted to participate in a trial at Dana Faber. I am learning the pitfalls of hospital staff not talking to the other hand.
"but he would check with the trial OC" so can you do the follow up call about this? Or at least a follow up email? I believe that it is in there interest to have someone with 5 bone mets instead of only 3. The Lutetium should mopp up the rest. Or you could come to Perth like Mateobeach... He had only 2 Lutetium infusions. I think 2 weeks apart. That would be even better for you?
TA pointed me to this trial. It’s phase 1 but it is only recruiting 6 people at MSKCC NY. I normally don’t look for phase 1, but it is phase one because they are combining two approved treatments SBRT and Lu177
Thank you for updates on your treatments, I hope you the best. I have been told a PMSA scan is necessary before starting the LU-177 treatment, but isn't there several PSMA scans? If so, which is recommended?
Hi docbulldogIn Australia the main use is gallium-68 PSMA PET-CT (Gallium PSMA-PET scan and CT scan). Im aware that there are various kinds of PSMA-PET scan available but am not qualified to advise on which may be "best". For Lutetium therapy, they also do an FDG scan to find out if there is concordance between PSMA and non-PSMA avid lesion areas. Issues occur if there are non-PSMA expressing tumour areas.
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Lu-177 continue or not ?
Lu-177 update
