Is VERU-111 (Novel Oral Tubulin Inhibitor) similar to Fenbendazole or Mebendazole?

[cigafred]

Does anyone have enough background to tell me if this looks like something similar to fenbendazole and/or mebendazole?

VERU-111 is an oral, next-generation, first-in-class selective small molecule that targets and binds to the alpha and beta-tubulin subunits of microtubules in cells. Microtubules are essential components for cell division and for shuttling critical growth receptors into the nucleus, where they stimulate cell proliferation. Unlike taxane chemotherapy, which only binds the beta subunit of tubulin, VERU-111 binds strongly to both the alpha and beta-tubulin subunits. Additionally, VERU-111 inactivates by cleaving poly ADP ribose polymerase (PARP), which is important for DNA repair in cancer cells.

urotoday.com/conference-hig...

[Tall_Allen]

No, not at all similar. It's more similar to taxanes (docetaxel, cabazitaxel) in that it stabilizes microtubules so that the cancer cell cannot divide. It also acts as a PARP inhibitor. It is a kind of chemo.

[cigafred in reply to Tall_Allen]

Thanks, and this is neither important nor aimed at boosting fenbendazole, but I thought that the presumed activity of fenbendazole was to do the same. At first check I cannot find an authoritative source, but there are many references like this: "Fenbendazole is in a class of medications called benzimidazoles, and the main action of these drugs is to inhibit tubulin polymerization. Drugs that inhibit tubulin polymerization are sometimes called microtubule inhibitors and are some of the most frequently used anti-cancer drugs. Taxane-based drugs and vinca alkaloid-based drugs are both examples of chemotherapy drugs that are microtubule inhibitors. Microtubules are like little ropes that are used to move things around the inside of a cell. They are especially important during cell division (aka. mitosis) when they move and separate chromosomes (genetic material) before it can be replicated. If a medication prevents microtubules from doing their job correctly, cell replication can’t be completed, and the cell will die. In cancer medicine, these drugs are used because cancer cells typically reproduce and divide faster than healthy cells."

longevitymedical.com/blog/d...

[Tall_Allen in reply to cigafred]

I think you are talking about the difference between a cannon and a pea shooter.

[cigafred in reply to Tall_Allen]

Yeah, that is how I feel when I compare my brain to some of the cannons here like yourself.

[Hidden in reply to cigafred]

Thankyou!

[Magnus1964 in reply to Tall_Allen]

Happy to hear that, my research doctor is thinking of putting me on VERU-111 at the next phase level.