Olaparib

[Sun1115]

Olaparib, is this drug our new hope? I recently read some interesting things about . That it could be a cure for advanced prostate cancer . Does anybody have any input on this ?

[Tall_Allen]

Sadly, it's not a cure. But it is a very good therapy for men with mutations in their BRCA genes. Here's some more info about its use:

prostatecancer.news/2019/10...

[6357axbz in reply to Tall_Allen]

TA, is the reason they are doing these trials on men with gene mutations, which I think is a small subset of Stage IV mPCA, because they already found it didn’t provide a benefit to the larger group?

[Tall_Allen in reply to 6357axbz]

Yes, they did trials on the larger group with any kind of DNA repair mutation and only found a benefit in men with BRCA mutations. PARP is a gene that repairs the cancer's DNA, so PARP inhibitors prevent repair.

[6357axbz in reply to Tall_Allen]

Thanks

[George71 in reply to 6357axbz]

I posted the trial article on it yesterday scroll down the posts it is titled

"Hang in there -- its happening"

here is the link

eurekalert.org/pub_releases...

[Hidden in reply to George71]

I finish my Radium 223 treatment in early October. It then sounds like I get a break for 2-3 months (other than Lupron). After the break, with monthly blood tests, I will begin the following trail with a PARP inhibitor. They Docetaxel/Carboplatin is used to enhance the Parp Inhibitor Rucaparib. I am not sure how it is different from Olaparib. Below is the descriptor of the trial. I am BRCA mutation positive.

Docetaxel, Carboplatin, and Rucaparib Camsylate in Treating Patients With Metastatic Castration Resistant Prostate Cancer With Homologous Recombination DNA Repair Deficiency,

[Hidden in reply to Hidden]

Thank you for doing the trial.

[Curehunter in reply to Hidden]

Is this the Triton 3 trial?

[Hidden in reply to Curehunter]

This is the only information I have at this point....

PLATI-PARP: A Phase 2 Study of Induction Docetaxel and Carboplatin followed by Maintenance Rucaparib in Treatment of Patients with Metastatic Castration Resistant Prostate Cancer with Homologous Recombination DNA Repair Deficiency

[Patrick-Turner]

Tall Allen is right about Olaparib. It helps some men with Brca1 and Brca2 genes.

I just got results back from geneticist for DNA analysis of a blood sample, and there are ZERO genes that indicate I have any DNA faults likely to indicate I was a sitting duck to get Pca or any other disease. Quite a large number of genes were looked at and nothing was found to indicate any cancer was likely, or anything else. My Mum lived to 98 without getting major cancers and I may have similar DNA to hers, but I am a man, and maybe still got enough DNA from my Dad's branch of family tree to get Pca, and his branch of family mainly died early from cancers. He died at 60 from Melanoma.

It does not look like I'll ever be treated with PARP inhibitors like Olaparib. It would not work. Maybe something else would. but I have to wait until something else becomes available therapy.

But I am now into second round of Lu177, maybe this works well, but after first round last year, Psa 25 went to 0.32 a year later, then bounced up to 30 in 8 months. Its now back to about 10 after 5th Lu177 shot last July 24. Next 6th Lu166 is next week, and I hope the 2 shots lower Psa again to so low that having more Lu177 would be useless.

But Pca is like a weed, it grows back up again so I'll probably need more Lu177 next year. Then comes a time when I can't have any more due to accumulated toxicity, so I might be allowed to have Radium 223, because Pca is now mainly in my bones. Recent PsMa scans over last 12 months show no soft tissue mets, only bone mets, and these are the most difficult to kill with anything.

Patrick Turner.

[45yrsDenmark in reply to Patrick-Turner]

I read somewhere that Lu-177 tends to work better on soft tissue than bones. Just keep that in mind..

[Balsam01]

There are lots of comments on this site about side effects. If you search "Olaparib", many comments will come up. Several are from women.

[RalphieJr64]

I got two good years out of it.