Olaparib

[elainea53]

My husband is in a phase 2 trial with Olaparib. He does not have the Barca gene. The full does of 600 mg made him too weak so taking 300mg. His hemoglobin is down to 9. He is weak but better than the full dose.

So if he doesn’t have any of the mutations will this drug still work. Anyone know?

[pjoshea13]

Hi Elaine,

Is this the clinical trial? [1]:

"The goal of this clinical research study is to learn if olaparib, when given after treatment with cabazitaxel, carboplatin, and prednisone, can help to control aggressive variant prostate cancer (AVPC). The safety of these drugs will also be studied.

This is an investigational study. Cabazitaxel and carboplatin are FDA approved and commercially available for the treatment of certain types of prostate cancer. Prednisone is FDA-approved and commercially available as a corticosteroid. Olaparib is FDA approved and commercially available for the treatment of certain types of ovarian cancer. The combination of cabazitaxel and carboplatin followed by olaparib in this study is investigational."

From an Olaparib study paper ten years ago [2]:

"Objective antitumor activity was reported only in {BRCA} mutation carriers, all of whom had ovarian, breast, or prostate cancer and had received multiple treatment regimens."

You say that he tested negative for BRCA, but was he negative for other mutations that might respond to a PARP inhibitor?

-Patrick

[1] clinicaltrials.gov/ct2/show...

[2] nejm.org/doi/10.1056/NEJMoa...

[elainea53]

Pten loss and TP53 R282W are ones that showed up on foundationone

[Tall_Allen]

All I can tell you is that it works much better in men with the BRCA mutation compared to men who have functional BRCA genes:

pcnrv.blogspot.com/2019/10/...

[ArabianNights]

Hi Elaine.

I am waiting for my father's genetic testing results. We are trying to decide if we should still do the trial with Olaparib even if he doesn't have the BRCA mutation. What results have you seen if any?

[elainea53 in reply to ArabianNights]

My husband was taken off lypanza trial at mda. Now waiting to start a radium treatment.

[elainea53]

He does not have brca