Seeking olaparib information

[Goldberg]

Will be starting on 0LAPARIB in the next few weeks and going off Xtandi I have Mets To My bones and lymph glands. Has anyone relevant information regarding response rates and costs. I Normally do not qualify for help. II am BRCA two. I appreciate any information you have available. I will be starting this at UCSF.This disease is hard to figure out some times which direction to go. Thank everyone onThis site for all their help And advice

[tango65]

The response rate in patients with BRCA2 is good , around 75%. This article has some info:

ncbi.nlm.nih.gov/pubmed/307...

[2dee]

I too am BRCA2 positive. My MO's plan is to use OLAPARIB or something similar WHEN Leupron fails because I am positive. Not available if not.

Keep us posted on progress if you find a way to give it a try.

2Dee

[vandy69]

I had Lynparza for about 9 months after being diagnosed with ATM defect. Medicare Rx plan covered it and do not recall any specific side effects.

Best wishes. Never Give In.

Mark, Atlanta

[p3d1]

I am on the TRITON 3 trial for the past 8 weeks, the drug is Rubraca not OLAPARIB but the response for all PARPi seems to be the same. 30% have a good response, 40% stable and 30% come off the drug. Which type of BRCA2 are you? Germline or somatic? This may alter your side effects.

Regarding costs, the TRITON 3 trial is still recruiting, and it covers all costs for the treatment.

[Goldberg in reply to p3d1]

Thanks for your input hope I will be in the 30%. My Brca 2 is germline

[KAYTCOLE]

Hi Goldberg! I'm new here but wanted to say my Husband is Stage 4 PC since 10/2015 and has been on Olaparib for 6 months now. The CT and bone scans have been steady but the PSA went from 215 to 1100 right after he started. It's down to 790 from the April 13th and next appointment is June 16th. He goes through the VA because he is a Veteran. This is one of many studies we've been through. The only side effects which just started are his feet and ankles have started to swell and he has some blood clots on his lungs but they say that comes from just the fact of having and treating cancer. He's 65 soon to be 66. Other than the nausea and fatigue sometimes that's about it. Dexamethasone has helped keep his weight up and give him energy. But he washes the vehicles and gets around pretty good most days. Don't know if any of this is helpful but keep pushing on and keep fighting. Most studies are free and some will actually pay you for your troubles! Best of Luck to you Goldberg!