Olaparib-Keytruda Trial

[scarlino]

Update of my adventures on this trial:

11 days in after 1 infusion of Keytruda and taking four caps of Olaparib I developed a significant rash all over my body. Went to Emergency room. Steroids knocked it down had me suspend Olaparib until my next visit 10 days later. Dr. Was surprised at this, said rashes don’t usually show up until later. Also vomiting a number of times. So he’s hoping the stopping of Olaparib will allow my body to reset. I will make sure I have Benedryl on hand to curtail it if possible. Still too early to see if it is working.

[SPEEDYX]

It's a battle every step on the way...Trusting treatment will be effective 🙏

[scarlino]

Sorry, 600 mg Olaparib daily (300 mg twice daily 12 hours apart).

[Fairwind]

After a Foundation One genetic test showed Olaparib might work for me, my VA oncologist put me on it..For a few weeks it worked well, my PSA showing a significant drop..But my Red Blood Cell and Hemoglobin counts also dropped to the point I needed a transfusion...Onco cut Olaparib dose in half..It stopped working, PSA resumed its rapid rise (5300 now) RBC's still very low..Lots of things going on backstage, I'll start a new thread later..

[HopingForTheBest1 in reply to Fairwind]

Did the genetic test show you being BRCA2+?

[henukit]

Thanks for the update. I was planning to participate in that trial but after brain metastasis showed up I became not eligible. But got approval for off-label Keytruda. So now I'm on the same combination of Lynparza and Keytruda. About 4 weeks after first Keytruda infusion I had very difficult couple weeks with constant fever and immense tiredness, basically hardly even moved. Then it slowly subsided, I had a second infusion (once in 6 weeks). I also had to back off Olaparib down to nothing and then gradually increase back to the original dose. Now I'm on standard 600mg. RBC is a bit below normal range as well as hemoglobin.

I'm struggling with nausea, food aversion and lack of appetite, constant tiredness and sleepiness. I'm taking ginseng and ursolic acid to counteract lack of energy. I'm trying to exercise as much as weakened body and low energy allows.

It should work, stay strong!

[scarlino in reply to henukit]

Thanks for sharing. I will be on lookout for those things. Stay strong and be blessed on your journey!

[scarlino in reply to henukit]

My Keytruda is every three weeks.

[j-o-h-n]

FYI I've had 16 treatments (1 every 3 months) of Keytruda for my Lung Melanoma and never had a side effect from the meds. BTW it's working and stopped treatments on 01/10/2018.

Good Luck, Good Health and Good Humor.

j-o-h-n Saturday 09/19/2020 7:00 PM DST

[donits in reply to j-o-h-n]

Hi J-o-h-n.

Are you still taking Fenbendazole? Have you noticed the positive effects of this treatment, any side effects?

Best regards and I also wish you a good sense of humor.

[j-o-h-n in reply to donits]

Hello donits,

I have never taken Fenbendazole.......But driving in NYC I've had a few FenderBendersFromDasAzole drivers.....

Good Luck, Good Health and Good Humor.

j-o-h-n Monday 09/20/2020 5:15 PM DST

[donits in reply to j-o-h-n]

Hello J-o-h-n,

Thank you for your post.

I confused you with another forum member ( also J-o-h-n ) who wrote me a year ago that he mixes fenbendazole with oatmeal for breakfast.

However, I would like to point out that even if you were taking (secretly) fenbendazole, there is nothing to be ashamed of. Many forum participants are taking fenbendazole and no one is ashamed of it. Me too.

With love,

donits

[j-o-h-n in reply to donits]

No problem....

I am not ashamed of the meds fenbendazole but I'd rather eat donits for breakfast.....

Good Luck, Good Health and Good Humor.

j-o-h-n Wednesday 09/23/2020 10:43 AM DST

[donits in reply to j-o-h-n]

Hi j-o-h-n,

Thanks for your post. I think we have something in common because I love donits too, but I think my memory is better than yours

[j-o-h-n in reply to donits]

Oh Yeah!!! Those are_________ words.... (Hold on, I'll fill in the gap as soon as I can remember what kind of words)???

Good Luck, Good Health and Good Humor.

j-o-h-n Thursday 09/24/2020 11:42 AM DST

[Peterd110]

How is the trial going now?

[Peterd110]

How are you doing now?