What should I expect?

[Seabird12]

Hi, I just want to know what I should expect next?

My husband diagnosed in January being on prednisone and zytiga since then , psa undetectable, started radiation a month ago , 10 more days left , meanwhile he had a test , it seems his liver shows abnormality, OC asked to stop zytiga for a while and have a MRI scan , what it means to you ? What gonna happen to him?

[Tall_Allen]

If the liver enzymes normalize when off Zytiga (he should not stop prednisone abruptly), the doctor may ask him to restart at a lower dose.

[tango65]

Zytiga could cause an elevation of the liver enzymes. This situation could be managed by decreasing the dose of Zytiga depending on the magnitude of the increase of the enzymes or bilirubin. If the problem persist when taken only 500 mg, Zytiga should be discontinue .

accessdata.fda.gov/drugsatf...

[LearnAll]

Zytiga can be restarted at 250 mg a day with full fat breakfast.

[Frigataflyer in reply to LearnAll]

I have been on Zytiga (+ prednisone and Lupron) for three months. My biggest problem in taking zytiga is scheduling the daily 500 mg doses of zytiga so they fall on an empty stomach. Recently, I have read some comments To the effect, that the dose of Zytiga can be reduced to 250mg, if it is taken with a full fat breakfast. Could someone please provide more info or a few references about this approach. Thank you.

[LearnAll in reply to Frigataflyer]

There was a research study published by University of Chicago late last year where they found that bioavailablity of Zytiga (Abi) is the same if 1000 mg is taken empty stomach OR 250 mg of Zytiga taken with full fat breakfast. This study results were published in many popular magazines and newspapers.

We had a discussion about this topic on this forum about 8 or 10 months ago. If you search it you might find that thread.

[Frigataflyer in reply to LearnAll]

Thank you

[Hidden]

He will be ok . Just get him through the chemo for now .. His body is under attack . Recovery takes time also .. Apc is nerve racking all the way .. so many gray areas ? .. you’ll receive answers here .. Heal him with love💕

[SPEEDYX in reply to Hidden]

Nerves are definitely racked