Castrate resistant

[Fight11]

Is being castrate resistant treatable? If so what drugs do they usually use for treatment? Can some share your story about being castrate resistant. My husbands psa is double each month the Dr is going to try Zytiga along with the Lupron which really is working by itself.

[Tall_Allen]

Zytiga works on men who are castration resistant. Castration resistant just means that the cancer progresses when on Lupron alone.

[Fight11 in reply to Tall_Allen]

Are you castrate resistant? My husbands psa last month was 10.49 it is now 19

[anit_t in reply to Tall_Allen]

Does zytiga always work for castrate resistant men? It didnt work for my dad right at the start. Same with enzalutamide. Now has completed some chemo cycles. Would zytiga or enzalutamide work now?

[Tall_Allen in reply to anit_t]

It is approved for castration-resistant men. You can try to re-challenge with Zytiga or Xtandi after chemo.

[Hidden]

Many of us on the forum are castrate resistant. Guys can go quite a long time on Zytiga or Xtandi after becoming castrate resistant. When my PSA went up to 26, I started on Zytiga and 2 years later my PSA is undetectable. Eventually that will become ineffective and then generally the best treatment is chemotherapy.

[mklc in reply to Hidden]

Good morning gregg,

How long do you mean by 'quite a long time'?

Sincere thanks. Mike

[Fight11 in reply to mklc]

??

[Hidden in reply to mklc]

When you have stage 4 cancer, I would consider 2 or more years a long time.

[mklc in reply to Hidden]

I should clarify, can you give a length of time that Zytiga can be effective for? Reference what you mentioned about Zytiga or Xtandi being effective for quite a long time.

Many thanks

[Fight11 in reply to mklc]

Someone else mentioned that. I would like to know as well...

[mrscruffy in reply to Fight11]

I am currently at 18 months with undetectable PSA.

[Hidden in reply to mklc]

The median progression-free survival is around 15 months. There's more information here on the prescribing sheet where you can read the clinical trial data.

janssenlabels.com/package-i...

[mklc in reply to Hidden]

Thank you so much. Best of health to you.

[mrscruffy in reply to Hidden]

If the median is 18 then the high end should be about 3 years

[Hidden in reply to mrscruffy]

Or more, lots of guys get between 2 and 3 years. My doctor said he had one guy that got 6 years.

[Fight11 in reply to Hidden]

2 to 3 years survival or meds working

[mrscruffy in reply to Fight11]

meds working

[Fight11 in reply to mrscruffy]

Have they always worked? My husbands Lupron stopped working his psa is rising

[mrscruffy in reply to Fight11]

for me yes

[Magnus1964]

Has he been on casodex or xtandi? They work in a different way from zytiga.

[Fight11 in reply to Magnus1964]

No he hasn’t

[Magnus1964]

He could try casodex, then if that doesn't work go to xtandi.

[Fight11 in reply to Magnus1964]

Will that bring down the psa as well as Zytiga and Xtandi

[Magnus1964 in reply to Fight11]

Casodex is a good first step . It is an older ADT drug . Zytiga and xtandi are may have some side effects, put those In reserve.