Castrate resistant

[hersheyboy]

If one is determined castrate resistant on Lupron and Zytiga, why is the standard of care to remain on Lupron when the cancer has moved on to different fuels?

[BarronS]

Because it still helps with any cancer that may still be hormone sensitive. Have you become castrate resistant?

[Tall_Allen]

As castration resistance sets in, the cancer becomes exquisitely sensitive to even the smallest amount of androgens, so it is more important than ever to be totally testosterone free.

[pjoshea13]

CRPC means being resistant to castration - not androgen independent. I would not categorize testosterone as PCa fuel, but in most CRPC, the androgen receptor remains in play. Drugs that target the androgen receptor axis need basic ADT to continue.

-Patrick

[Magnus1964]

Your doctor should recommend other ADT drugs. They all approach Pca in different ways. He/she should be trying casodex or zytiga.

[Drcrunch]

There are a mixed population of cancer cells. Most may be castrate resistant but some are still sensitive to androgens.The adt drugs are for them.