Castrate resistant

[wolverine11]

Have become castrate resistant to abiraterone after 3 1/2 yrs.. Oncologist wants me to stop aby before starting chemo because aby may make chemo less effective, does that sound right?

[GP24]

If Abi does not work you can avoid its side effects during chemo.

[wolverine11 in reply to GP24]

Thank you

[Tonyliv]

I was on abiraterone for 5 years, and only stopped as it became ineffective. I continued it whilst i had targeted radiotherapy; but yes, a bit pointless whilst on chemotherapy.

[jackwfrench]

Hello - Not sure, but a question - I am one year in on Lupron and Abi and wondering about CR timing - were you also on something besides Abi? Have seen some articles on Abi as monotherapy.

[wolverine11 in reply to jackwfrench]

I am on Lupron of which I will continue on, also will stay on prednisone. With high volume metastatic PC, in general I have read, on average Castrate resistance sets in about 3 yrs. Of course there are exceptions to that

[kiteND]

My docs have kept me on ADT although I am castrate resistant. Their view is that it is still working and doing something. Maybe that is because I am still low volume.

[wolverine11 in reply to kiteND]

Thanks That's what I was wondering, if staying on zytiga would still block cancer growth while doing chemo. I am high volume.....Perhaps others have more info. on this site.

[wolverine11 in reply to wolverine11]

Just found the answer. taking zytiga while on chemo causes more side effects, possible liver toxity for example.

[Tall_Allen]

Consider the PRESIDE protocol (switching to enzalutamide and adding docetaxel):

prostatecancer.news/2022/10...

[wolverine11 in reply to Tall_Allen]

Thanks TA...Oncologist and I discussed taking Xtandi. But did not go into details of when to start Xtandi. When I see her I will tell her about the PRESIDE trial......

[Tall_Allen in reply to wolverine11]

Suggest you email the link before you see her.

[wolverine11 in reply to Tall_Allen]

Thanks TA

[Mbnm in reply to Tall_Allen]

Mistakenly missed 5 days of Abiraterone treatment….started again but concerned..would it be wise to increase dosage for a couple days….my next labwork scheduled for December…up till now treatment has worked well with very low psa and t levels….really hope I did not screw up…your help would be greatly appreciated thanks

[Tall_Allen in reply to Mbnm]

Don't increase the dose. Max plasma concentration is just 2 hours and steady state concentration is achieved within 8 days. More important is to not miss prednisone doses.

[dk73]

once aberaterone stopped working, they tried Xtandi but that didn’t work either so back to chemo (he started with chemo after his surgery/radiation). He had 9x of taxotere but 10 months later PSA was rising so did pluvicto. Did 4 rounds of that but experienced a massive spread of bone Mets. Now doing Jevtana. He did eligard alongside all these treatments, every 6 months.

[wolverine11 in reply to dk73]

I hope he has a good outcome

[old64horn]

Wolverine, I'm sorry but I never had chemo. I had radiation to the prostate bed when my PSA became detectable seven years after surgery, I wish you luck.

[wolverine11 in reply to old64horn]

Thank you.... feeling very sick today wonder if I can get emergency chemo at hospital

[Mbnm]

long story but I stupidly mistakenly went off Abiraterone for 5 days …back on it again i am concerned…should I temporarily increase the dose slightly? Should I ask for a blood analysis to see whathappened to my PSA and T which have been very low? My quarterly blood test is not till yearend . So dumb?.help would be appreciated

[wolverine11 in reply to Mbnm]

Tall Allan or others can probably give more information about your concern

[Mbnm]

have you considered Pluvicto Lutetium injections .?