Have any of you been castrate resistant and Xtandi or Nubeqa has worked?
Castrate resistant : Have any of you... - Advanced Prostate...
Castrate resistant
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Good Morning Fight 11I started Nubeqa about 2 months ago.
I am castrate resistant and non metastisized, PSA was rising even though I was on another (3rd or 4th) round of Lupron.
I have a Gleason 9 so I didnt want to watch and wait as PSA climbed deom<.1 to .2 to .05 then .7, 1 and 1.07 and then 1.77. So I was lucky enough to get with Dr Taplin at Dana Farber and she prescribed Nubeqa. In 2 months I am down to .6Next appointment at DFCI is 3/29 so I should know more then.
The VA is paying the tab. I am 100% service connected out of Viet Nam.
If either works, your not castrate resistant.
So in other words if your castrate resistant it won’t work ? Wonder why the MO said let’s try one or the other!
In my humble opinion its not relevant to look at this as whether castrate resistant or not. He has progressed under multiple treatments no matter what one wants to label the castrate situation.By now the cancer is complicated. It has mutated. It has found work arounds to various treatments.
He has not had Xtandi yet and it might do some good. The recent chemo he had might even cause the Xtandi to work better.
Wont know of course until it is tried.
Hang in there. I hope you guys get a break, some time with no progression.
If the scans show significant bone metastasis and especially if he has pain from them you might consider a new posting : Is there benefit to adding RA223 therapy to Xtandi?
However if I remember correctly his blood markers have been low due to poor bone marrow so RA 223 might be difficult.
Darolutamide, sold under the brand name Nubeqa, is an antiandrogen medication which is used in the treatment of non-metastatic castration-resistant prostate cancer in men. It is specifically approved to treat non-metastatic castration-resistant prostate cancer in conjunction with surgical or medical castration. Wikipedia
Xtandi is given for metastatic castration-resistant PCa. Nubeqa is only approved for non-metastatic castration-resistant PCa.
Xtandi is working for a close relative of mine, elderly. The side effects are pretty tough--but it's working.
When I was dx 5 years ago, I was immediately put on Lupron every 12 weeks and 6 rounds of chemo. My PSA reached 0.1. Fast forward 3 years later. my PSA jumped to 6.4 which is when my Onc put me on Xtandi. 2 years of Xtandi and my PSA is still undetectable. there are others here who have been on it longer. Hope that helpsNick
Our MO used to say the resistance is not a sharp line but a gradient. Even when declared resistant, some cells will get the benefit of hormone based medications. My husband's ADT alone stopped working to hold PSA back, they added Enzalutamide and when the PSA rises on that, they are trying radiation of the bone mets as of today.
My husband's psa was rising rapidly, doubling about every month while on Eligard only. PSA had reached 5.9 in December. He had a pylarify scan in January with Dr. Sartor at Tulane and approximately 8 retroperitoneal lymph nodes showed positive. No other metastases were identified (no bone or liver) and Dr. Sartor put him on Nubeqa. Two months after starting Nubeqa his PSA was at 0.64. I believe my husband would be characterized as metastatic because of the retroperitoneal lymph nodes. Dr. Sartor is very pleased with the results he's getting with Nubeqa. Medicare approved the drug for him. That being said our Part D co-pay for the medication is $2400 a month. Medicare pays about $6000 and about $4000 is disallowed. Ouch.
Doesn't your insurance plan have a maximum out-of-pocket costs limit, which when exceeded the plan pays most of your prescription costs the rest of the year? Mine does, and it's $6,550.00. Mine is aptly called Catastrophic Coverage.
It works for me. Gleason 9 post RP, post radiation, post 3 times om Lupron.PSA began to rise. Non metastatic. Began Nubeqa 1/18/22. PSA down from 1.77 to .63. It had been rising very fast after a Lupron holiday. When I started back on Lupron PSA kept steadily rising. Just back from Boston yesterday. Very pleased with the results this far.
We tried to get Nubeqa!! We were told that it’s not FDA approved for CRPC so insurance companies don’t approve it often so we ended up with Xtandi. Hope it works and not a lot of side effects. Heard Nubeqa is more tolerable.
There is always a clonality of cells..some will be hormone sensitive...So you can still continue to have some response to Xtandi for some time