Castrate resistant

[Fight11]

What is the life expectancy of someone who is castrate resistant? On an average. What meds are all of you on for it. Has it worked and for how long?

[LearnAll]

Varies from person to person but I heard it is normally 3 to 5 years. But on this forum there are people who are alive and kicking after 10, 16 and one even 27 years. It depends. No fixed number can be given Length of survival depends on many factors..besides meds and chemotherapy...factors such as your general health, level of physical activity, level of inflammation in the body, co-morbid illnesses, antioxidant, anti inflammatory diet, support system, relaxation and meditation, mostly plant-based anti oxidant diet, avidance of obesity, good control of blood pressure , cholesterol and Diabetes.

Herbs and spices also help. They include Turmeric, Ginger, Onion, Garlic, oragano, Grapes (resvestarol) Cruciferous vegetables (cabbage, Cauliflower, Brocolli, Radishes) , fruits like Guava, soursop, pomegranade etc. Vitamin D3, Yogurt and Green leafy vegetables to keep bones strong Herbs like holy basil, parsley, black cumin, . Avoidance of excessive alcohol and saturated fats. Drinking Green and Black tea daily .You get the point....All measures contribute some and cumulative effect causes longer life.

[Hidden in reply to LearnAll]

I agree with no fixed numbers, but 10, 16 and 27 years from diagnosis not from begin castrate resistance, or yes?

[LearnAll in reply to Hidden]

Those who live 10 ,16 or 27 yrs are outliers..very uncommon but possible in few cases. Most common range is anywhere from 3 to 5 years with optimum management.

Now a days..because castrate resistant meds are started from day 1 with Lupron..so it becomes hard to sort things out clearly.

[Fight11 in reply to LearnAll]

Are you castrate resistant

[LearnAll in reply to Fight11]

Not yet. I am only for 15 months in this. Right now on vacation from all meds for last 8 months and monitoring biomarkers very closely. I am doing Intermittent Androgen deprivation therapy.

[Fight11 in reply to LearnAll]

I had 42 rounds of radiation last summer also on Lupron. Six months after radiation my psa was 0.1 6 months after that which was July of this yr is now 10.49 it jumped that much in 6 months. Had a bone scan showed some Mets. Now the Dr wants me to try Zytiga

[LearnAll in reply to Fight11]

Very important point to remember is that every man's prostate cancer is different ..some ones cancer is like a "dove" gentle and less harmful...other ones is like "vulture" mean and very harmful.

If you find that your cancer is "vulture type" meaning more aggressive than you need to be aggressive in beating it too. Find out the nature and behavior of your cancer and deal with it accordingly.

[Fight11 in reply to LearnAll]

Is yours aggressive

[LearnAll in reply to Fight11]

Based on my cancers behavior, clinical symptoms, level of biomarkers, lab results .scans .my doctors think that it does not seem very aggressive and therefore we do not have to be too aggressive with it.

[BarronS in reply to Fight11]

Make sure to be up to date on all of your vaccinations. Make sure to keep your immune system strong through any vitamin supplements and nutrition. Be careful during flu season. These are things I wish I was told when my father was going through the journey.

[Ahk1 in reply to BarronS]

BarronS,

What type of vaccinations you mean please?

I have not been vaccinated for anything and hope I didn’t miss important ones.

[BarronS in reply to Ahk1]

pneumonia and whatever flu vaccine is being given during the season. Just stay vigilant during flu season too. Avoid people that have small children during Chemotherapy. Your immune system will be weakened and small children are disease factories.

[Cateydid in reply to LearnAll]

This is a great response!

[Magnus1964]

With the recent studies showing that there are drugs that can extend the efficacy of ADT drugs yourquestion becomes even more fuzzy.

I was on a drug trial with xtandi plus a mystery drug. The trial lasted 3 1/2 years. I am still taking xtandi on my own with Quercetin. So far so good.

[Fight11 in reply to Magnus1964]

Would you please be able to share your story with me

[Magnus1964 in reply to Fight11]

As I said, I was on a drug trial with Xtandi and a mystery drug . The only designation given to the Mystery drug was a alpha/numeric designation from Eli Lilly that was suppose to extend the efficacy of xtandi. I never found out what if anything came of the mystery drug but I got 3 1/2 years out of it. My Research Doctor told me I was the last man standing on trial in the entire country.

After the trail ended my PSA began to rise. I stayed with xtandi and added quercentin, a supplement that is suppose to extend the efficacy of xtandi I am still on the xtandi and my PSA is elevated but flat. It has bounced around between 50 and 55 for the last 4 months.

that is my person experience. I believe there are other drugs being pursued to extend the life of other ADT drugs but I am not in a position to say much about them.

[konichiwa12]

I am taking Zytiga and Prednisolone. I have read the replies and I was hoping for more than 3 - 5 years but I know I have an aggressive disease. Sadly this is playing on my mind a lot during Covid lockdown!

[Tall_Allen]

Read this:

menshealth.com/health/a2530...

The drugs approved for castration-resistant men are Nubiqa, Erleada, and Xtandi if metastases haven't been detected on a bone scan/CT, and if they have: Zytiga, Xtandi, Taxotere, Jevtana, Provenge, and Xofigo. Also, Lynparza and Rubraca if BRCA+; and Keytrua if MSI-hi/dMMR. Many more in clinical trials.

[JNunes]

Everything is so advanced in the world. More effective cancer control would be expected / desired by all of us...

[Hidden]

No one knows how long a man will live once they are castrate resistant. Some only live a year or two, others live for many, many years. It's impossible to predict the future. I have been castrate resistant for three years. (Or have I really been?) Currently my PSA in undetectable and my scans are clear. I run 4-5 miles four days a week and lift weights the other three days. I feel good and plan on living for many years. I have made it five and a half years so far. Original diagnoses was a PSA of 850 with numerous lymph node activity and four tumors on my bones. Bottom line, you never can tell.

[afab]

Things are moving so fast it’s hard to tell. I’ve been in durable remission for 6.4 years. Gleason 4+4 with 2 bone mets. On Xtandi and Lupron. PC research is well funded. Keep the faith.

[tango65]

If the cancer is castration resistant and there are not metastases it can be treated with darolutamide or apalutamide and the median progression free survival is 36 to 40 months. If there are metastases the treatments are less effective.

[Fight11]

The is some Mets

[ctarleton]

(USA) Approved drugs/treatment options for this situation are also listed in Chapter 9 of the NCCN Guidelines for Patients, Prostate Cancer.

nccn.org/patients/guideline...

Individual drug/treatments can also be researched further by Googling the drug name and "Full Prescribing Information". The collective results of the many patients who were in the Clinical Trials leading up to US FDA approvals are typically found within such documents.

It is always important to remember that numbers like "Overall Survival" in these trials are statistical entities, typically representing the amount of time (plus or minus, depending upon the sample size and other statistical factors) by which 1/2 of the men had died, and 1/2 of the men had not died. The total results for all the INDIVIDUALS shows up along a curve in the individual data points. If an individual is an "out-lier" with an unusual or aggressive disease or other things wrong, his data point could show a recorded death considerably sooner than the collective Overall Survival. Likewise, some individuals "have to be" at the "other end of the curve" in their treatment responses and survival durations.

(Anecdotally, I had very many "mets" and extensive disease from the beginning in Nov 2013, with a PSA in the thousands. Lupron worked very well for me for at least 2 years. I later went on to add Xtandi when castrate resistance happened, and it has worked well for at least 3 years. I am almost a 7 year survivor now, but will need another type of treatment soon. In light of more recent discoveries and clinical trial results, if I had to do it again, I might have opted to have had either Lupron + early Chemo (Docetaxel) or Lupron + early Zytiga, in hopes of a longer Overall Survival at the other end of the full course of my disease and treatments.

Others may get different recommendations from their doctors or second opinions).

If in doubt, keep asking your doctor for more information to help in the decision-making process.

Good Luck!

[db1966]

Difficult to not overthink it but there are many people like me surviving a stage iv (metastatic). 5 years since my diagnosis with a 212 PSA. Currently 0.2. Yes 0.2. Did chemo /lupron. I Take Zytiga and prednisone daily and Lupron every 90 days. Did some (outside the box) radiation in March this year (28 rounds). Feel great and working full time. Plenty of exercise helps.

We got a golden retriever 3 years ago and I can’t tell you how therapeutic that has been.

It’s a journey for sure but you become mentally stronger each day month etc.

Hope this helps.

[Fight11 in reply to db1966]

The Lupron isn’t doing it’s job my husbands psa is rising. They are adding Zytiga

[db1966 in reply to Fight11]

Zytiga will help significantly. You still have many treatment options so don’t panic.

[Fight11 in reply to db1966]

He has some Mets as well. Psa was 0.1 in Jan after 42 rounds of radiation the prostate couldn’t be removed it was fused to the rectum. Now the psa 6 months later is 10.49 😩😩😩

[Hotrod65]

All different life expectancies for us all that are crPC...Gleason 9 4+5..aggressive disease..surgery, Lupron, Chemo ,, had just about it all and given 3-6 months max, for Adenocarcinoma with Neuroendocrine differentiation pathology..next step was Genomic Sequencing of tumor, found I had a Hypermutated TMB and qualified me for Checkpoint Inhibitors Blockade immunotheraphy...6 yrs later I'm in Complete Durable Clinical Remission NED....infusions of Pembrolizimab Keytruda 48 total thus far with 2 to go by year end...no treatment required after that but 6 month clinic visits and yearly scans MRI and Bone., I am a walking miracle leading a normal life without limitations for a retired 65 yr old..thank God for Medicine advances in just the past 5 yrs...I currently Advocate and speak around the world on Genomics and Immunotheraphy advances for all types of cancer, I firmly believe it will be something other than PC that will be my Denise when my number is called..God Bless all us Warriors!.

[Fight11 in reply to Hotrod65]

My husband has some Mets as well. Psa was 0.1 in Jan after 42 rounds of radiation the prostate couldn’t be removed it was fused to the rectum. Now the psa 6 months later is 10.49 😩😩😩 he has been getting Lupron it’s not working. They are going to try Zytiga. Any suggestions you might be able to help me with so can tell the Dr

[Fight11]

Omg what a blessing!!!