Zytiga and prednizone

[Altamonttt]

My MO prescribed zytiga 250×4 pills daily with 10 mg prednisone. I'm cspc and all literature says to take 5mg daily and for crpc take 10 mg daily. Does anyone know why the recommend lower dose for cspc?

Thank you.

[6357axbz]

5mg for CS cancer. You can find this right there on Jannsen’s website. My original MO also prescribed 10mg but changed it to 5mg after I corrected him. Here’s the excerpt:

------------------------------- DOSAGE AND ADMINISTRATION --------------------------

Metastatic castration-resistant prostate cancer:

• ZYTIGA 1,000 mg orally once daily with prednisone 5 mg orally twice daily. (2.1)

Metastatic castration-sensitive prostate cancer:

• ZYTIGA 1,000 mg orally once daily with prednisone 5 mg orally once daily. (2.2

[Tall_Allen]

The anticipated duration of steroid use is longer with mHSPC than mCRPC. Also, corticosteroids have anti-PC activity that vanishes over time, so you don't want to use up its effect sooner.

prostatecancer.news/2019/06...

These are just guesses at suitable replacement doses, and individual needs may vary. With mHSPC, I think it's a good idea to start at the lower dose, and ramp up if there is high blood pressure, low potassium or edema.

[Altamonttt in reply to Tall_Allen]

Thank you. I asked MO todat via email and he said to continue with 10 mg. Will speak with him.

[CalBear74]

Not to change the subject, but are you aware that you are taking the standard dose which has been supplanted by the low fat meal strategy for reducing a daily Zytiga dose to a single 250 mg tablet. This of course reduces your cost of medication substantially.

[Dfrige]

All depends on your Doc and your own research. After initially starting with 4 Zytiga and 5mg prednisone. I went down to 1 zytiga and a 5mg pred along with a semi fatty breakfast. Results were the same. PSA dropped and remained low. Went off all meds last December.

[toml77 in reply to Dfrige]

Was there a study done on this. I mentioned it to my Doc on my last visit and he had never heard of it. Wants me to do some research on it.

[treedown in reply to toml77]

The original work was no think Univ of Chicago uchicagomedicine.org/forefr...

Pretty sure it is in the current NCCN Guidelines as well.

[j-o-h-n]

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