Prednizone Dose "Survey"- 5mg vs 10mg per day

[efsculpt]

Hi, all. I have been on Prednizone (with Zytiga, Lupron) for two years. Going "off" mid July. Prednizone, in addition to being necessary when taking Zytiga, thins the skin. My arm look like hell.

If there is a "next time" I am questioning the 10 mg per day I have followed.

So......

Who has taken Lupron, Zytiga, Prednizone and took only 5 mg per day of Prednizone?

Best Regards,

Craig

[Tall_Allen]

The replacement dose is 5 mg/day when used with Zytiga for mHSPC, 10 mg/day when used with Zytiga for mCRPC. Everyone is different - you may need more or less - if you want to experiment, make changes slowly and monitor potassium, BP and edema.

[Hidden]

I'm currently taking Zytiga and 5mg of Prednisone per day as recommended by my doctor. I agree with taking 5mg, so far it's working fine for me. I did take 10mg with Docetaxel chemotherapy, but just for the first 10 days after infusion. That made a huge difference coping with side effects.

One of the big concerns I have is a potential resistance path through the glucocorticoid receptor.

There is ongoing research on this subject. Here's an article:

ncbi.nlm.nih.gov/pmc/articl...

Taking 10mg with Docetaxel chemotherapy was short term (10 days X 6 cycles) vs. the much longer term use of Prednisone with Zytiga. I'm coming up on one year on Zytiga, hoping for much more. I'm going to keep at 5mg.

[bellyhappy]

I am taking Zytiga with 5mg Prednisone per day for the last 6 months...and once in three months, a Lucrin jab.

[Hidden]

My husband took 1000mg zytiga with 5 mg prednisone (mCRPC) with food for a year until Zytiga stopped working.

[dougnola]

Hi there. I’ve been on Lupron (every 6 months) plus Zytiga (daily empty) and prednisone 5mg (daily w meal) since July 2017. PSA (500 in 1/17) went quickly below 1 and ND early 8/18. Had all sorts of bruising, fatigue, flashes at first. It pretty much went away a year ago but I walk 10km/day, eat healthy, rest well and do weight training to prevent muscle/bone loss (with licensed trainer and docs’ consult). Osteopenia so far is slowing down w calcium and vit D. It’s a constant effort to not lose muscle though! Feeling great and will do this course as long as current results hold. Good luck!

[Hidden]

Allen’s answer should give you the proper standard dosage. Me? If was in your shoes, listen to your Medical Oncologist. Everyone is different with scope of disease and current treatment. For example, in 2004 I underwent a six month chemotherapy-hormone therapy clinical trial. It included 30 mg of Prednisone a day for the 180 day period.....

I wish you the best in kicking this bastard disease.

GD

[Schwah]

I started with 10 and went to 5 after about a year. I’m hormone sensitive. No difference for me. Interestingly I’m on a “vacation” from Lupron Zytega and prednisone as of two weeks ago and I had terrible side affects from weaning off my prednisone. Way more fatigue and malaise than the 2 years on. My workouts were a huge struggle. This lasted about 10 days and I’m just now starting to feel good now. Still on 2.5 prednisone daily (half) and will continue to wean to zero

Schwah

[efsculpt in reply to Schwah]

Thanks for the "going off" heads up. My fate in a month.

[Hirsch in reply to Schwah]

Why are you taking a vacation ?

[Schwah in reply to Hirsch]

after 21 months of treatment including lupron chemo zytega prednisone zometa Celebrex Metformin SBRT to my three mets and a resultant 1 year at between .01 and .02 PSA, I, my MO and a second opinion at Ucla thought a vacation to see if I had a long term remission or dare say a cure (there word not mine) was in order. I just did. Psma test at Ucla as a baseline to help determine any future disease progression. We shall see.

Schwah

[efsculpt in reply to Schwah]

Good Luck, Schwah. You are a month ahead of me. Set me a good example, will you?

Regards,

Craig

[Schwah in reply to efsculpt]

I’m not doing a very good job of that. Look at my latest post 🙈

[timotur]

Taking 5mg Prednisone daily with Zytiga + Lupron adjunctive to HDR Brachy done last week. I break up the 5mg tablet in halves, and take over the course of the day to spread out the dose.

[SeosamhM in reply to timotur]

Great suggestion, Timotur. I'm going to give this approach a try.

[RayF]

Lupron , Zytiga, and 5mg Prednisone for app 7 months. PSA has gone from 2.9 to .02.

Still lifting to prevent muscle loss, on Zumeta and Ca, D, K for bone health.

Gleason 9 with mets to bones.

[rrs18]

Easy answer. Me. Appears to be little difference between 5 and 10. At least in my experience.

[Tfly]

We tried decreasing from 10 to 5 and experienced a big jump in tiredness, lethargy. Same Zytiga, Lupron regimen. We went back up to 10

[SeosamhM]

5 mg/day with Zytiga (mCRPC).... I'm with you in my sensitivity to Prednizone, I cannot tolerate it every day, but monitor my BP a couple of times a day. Timotur has a great idea to keep some hormone-supplement in the system by breaking tablets in half....I'm going to give it a try. Good luck. - Joe M.

[jedgar1]

I have been on Zytiga and 5 mg prednisone for 15 months, 2 year treatment. I bruise just looking at me. My MO said he didn't understand why? All the other stuff too, tired, confused. I have lost 20 lbs. 151 to 131. But I work out really hard and results are good from that. I just don't have any desire to eat. It takes almost forcing myself to eat.

I have been T and PSA undetectable for 9 months. I just fear my next PSA like all of us.

[Hidden in reply to jedgar1]

I know what you mean. My BTA (blood test anxiety) rises rapidly every 3 months.

[timotur in reply to jedgar1]

I also bruise easily, nurse missed a vein last week and the bruise covers half of my forearm. Evidently it’s due to low RBC and platelet count.

[efsculpt in reply to jedgar1]

I've read that, and witness, my skin is like tissue paper. Very thin. My guess is the bruising is connected to the thin skin.

[leo2634]

My Doctor says 10 for me so 10 it is. I've been on Zytiga, Prednisone, Eligard for 17 months now PSA 0.1 since first month so why rock the boat.

[JazzMan42]

I started on 1000mg Zytiga and two doses of 5mg prednisone. I am hormone sensitive. My liver enzymes started going beyond a safe range so my MO reduced me to 750mg Zytiga and one dose with food of 5mg prednisone. So far so good - latest PSA dropped to 0.69 and enzymes back to normal. I take the prednisone with breakfast and the Zytiga at bedtime so I do not conflict with the 2 hour before and one hour after meals rules.

[jfoesq]

It's been a while since I was on Zytiga but when I was I took 5mg of Prednisone.

[Hirsch]

I take 7.5 daily and have since beginning of Zytiga therapy. I think what you are doing makes sense. What will the parameters be for “next time “ to start it again. You should see my arms. A mess. Good luck

[efsculpt in reply to Hirsch]

7.5mg is an option. I bought "arm guards". Run from the wrist to elbow, padded on the outside. They help a lot, if one remembers to wear them.

Regards,

Craig

[StePeteMN]

New here. Last month my oncologist suggested dropping down to 5mg. That was four weeks ago and I feel better, over-all. I'll see the urology guy at Mayo next week and ask if I should cut it in half again (but my dream would be to be told I should discontinue Zytiga!).