After Zytiga & Extandi....? - Advanced Prostate...

Advanced Prostate Cancer

22,277 members27,978 posts

After Zytiga & Extandi....?

4luvofrob profile image
17 Replies

Hi ... I cannot tell you how grateful I have been for this site over the past 9 years!

My Rob is a Gleason 9. He had his prostate removed in 2012, received radiation at Datolli in Sarasota, and was on Avodart, Zytiga, and Firmagon until it appeared that the Zytiga was failing last year...PSA was increasing and an Axium Scan revealed a met on the hip and a nodule in the pelvic area....and he was taken off the Zytiga and Avodart. He was given the Provenge treatment which was completed this past December and started on Xtandi, one and then, two pills in February when his PSA was 4.05, We have now learned that his PSA is up to 12 and his oncologist is going to Telehealth meet with us on Tuesday. Besides increasing the Xtandi (Rob nor the doctor feel he will be able to handle it at a higher dose.), what other treatment options would you suggest? Thanking you and praying for your safe keeping and good health during our present Covid crisis.

Written by
4luvofrob profile image
4luvofrob
To view profiles and participate in discussions please or .
Read more about...
17 Replies
Tall_Allen profile image
Tall_Allen

Docetaxel.

4luvofrob profile image
4luvofrob in reply toTall_Allen

Thank you, Tall_Allen!!! Blessings, b

Fairwind profile image
Fairwind

R-223 can be very effective against bone mets...For me Jevtana (Cabaztaxel) worked better than Doce and had fewer side-effects...

4luvofrob profile image
4luvofrob in reply toFairwind

Thank you, Fairwind...that is very helpful!!

DarkEnergy profile image
DarkEnergy

Also, discuss the "possibility" of rechallenging Zytiga or Xtandi after Taxotere (Docetaxel).

There's been increased interest in late, regarding sequencing PCa treatments. The last 3 years has been amazing,

Helpful healthunlocked link, relevant for you:

healthunlocked.com/advanced...

4luvofrob profile image
4luvofrob in reply toDarkEnergy

Yes, I have read about that and it is very interesting...Zytiga worked very well for Rob for about 5 years with very tolerable side effects...beyone fatigue and muscle atrophy...

First-line chemotherapy Docetaxel and second-line chemotherapy Cabazitaxel are both good, proven treatments.

Don't be afraid of chemotherapy. All chemotherapies are not the same as far as side effects go. These particular chemotherapies are quite tolerable for most.

I did 6 cycles of Docetaxel and it was not that bad. I would certainly do it again.

Cabazitaxel has less side effects for most. That will most likely be my next treatment.

Wishing you and him the best.

4luvofrob profile image
4luvofrob in reply to

Thanks, Gregg...that is encouraging...b

in reply to4luvofrob

I felt crappy for around the first week, but I also found a psychological benefit to that. That might sound strange, but you really feel like you are doing something against the cancer. You have a goal and a focus to get through each cycle. I was definitely happy to be done with it, but after I did find myself missing having a more active role in fighting the cancer.

MarkBC profile image
MarkBC in reply to

I never thought of it that way but I agree. I also agree with you that chemo was not as bad as I expected it to be.

4luvofrob profile image
4luvofrob in reply to

Thank you for the encouragement, Gregg...I will share it with Rob. Take care.

4luvofrob profile image
4luvofrob

Thanks, once again!!! I will definitely share your words with Rob....He and I both hoped he would never have to do chemo...but your experience is encouraging....My biggest fear for Rob is that it will wear him completely down...he is very fatigued and week now....but we will discuss it all and what the others have mentioned when we meet with Dr. Dawson on Wednesday.....God bless and keep you and all who have been so gracious to reply in such a timely and helpful manner. XOXOXO

erjlg3 profile image
erjlg3

You're an amazing Caregiver 💗

My continued love and prayers for both of you and prayers for this appointment to help Rob to get better and stronger.

🌻

4luvofrob profile image
4luvofrob in reply toerjlg3

Thank you and God bless you, precious friend....

Break60 profile image
Break60

Did he gave RT to pelvic lymph nodes at Dattoli or sbrt to bone met? I never jumped to second line ADT and instead went to estradiol after sbrt to bone mets. See my profile.

4luvofrob profile image
4luvofrob

Thank you ...Break60.....Rob's radiation was what Datolli called DART....it was to pelvic lymph nodes and to a spot on his pelvic bone though it was definitely confirmed to be cancer...

Survivor1965 profile image
Survivor1965

Not a doc to hard to prescribe anything, but when I was really bad I had Jevtana and carboplatin at the same time. Something my Onc in MN and Kwon at Mayo had come up with, and it worked well, knocked it right down. Then Lupron/Xtandi since. That was 3 1/2 years ago, PSA undetectable today. Btw, I started in 2012 also. Keep the faith.

Not what you're looking for?

You may also like...

Zytiga to Xtandi

Hello all! Just had my father’s latest oncology appointment today. After many years of being on...
PHnerd profile image

Starting Zytiga questions

My husband ended Xtandi as it was no longer holding/lowering his PSA. He is 76 and could only...
Grumpyswife profile image

Zytiga &Dexamethasone or what?

Dear all My dad started taking Zytiga with Prednisone 2.5 months ago and he would take PSA test...

Stopping Zytiga after 6months

After our last checkup with our med onco last Friday, he mentioned that my husband can stop taking...
dvcarola profile image

Zytiga after taxotere chemo? Help understanding

Hi everyone, My father has had 10 rounds of chemo (his last one is this week), he went from a psa...
ellie2211 profile image

Moderation team

Bethishere profile image
BethishereAdministrator
Number6 profile image
Number6Administrator
Darryl profile image
DarrylPartner

Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them.

Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked.