Starting Zytiga questions

[Grumpyswife]

My husband ended Xtandi as it was no longer holding/lowering his PSA. He is 76 and could only tolerate half dose Xtandi.

Questions regarding Zytiga. Do others take it at bedtime without food? This would be easiest as it follows the same pattern he had with Xtandi.

He would do the prednisone at breakfast and supper with food.

Also, have others done half dose Zytiga to tolerate SE? I don’t recall posts about that.

Thanks

Mary

[LearnAll]

zytiga is normally taken empty stomach and the dose for this is 2000 mgs. if some one

takes it with fatty food, the absorption of zytiga goes FOUR times, thus requiring only 500 mg dose . Fat increases absortion of zytiga significantly.

[Grumpyswife in reply to LearnAll]

Yes I read that but I don’t want to kill him or have him end up in the hospital. At this point I would rather not tweak it.

[whatsinaname]

I take 4 tablets of Abiraterone at 10 PM. I finish dinner by 7.30 PM. So that gives a gap of 2.5 hours. I take Dexamethasone after breakfast and dinner.

[Grumpyswife in reply to whatsinaname]

Ok Thanks. That would be an easier pattern for him to follow and we can always tweak it as needed depending on SEs.

[MichaelDD]

I always get up around 3am. Time I use to wake for work. Take them go back to bed. I take 2- 500mg for a daily total of 1000mg a day. My other half is a nurse she wakes at 5am and I get up to make her coffee. My breakfast I take my Prednisone.

Didn't know that there was 2000mg taken in a day. 4 tablets for me were first given at 250mg each. Now the 2 at 500.

[Grumpyswife]

His Abiraterone Acetate is from Mylan (generic) and the dose is 4-250 mg pills per day--the same as you are taking. I think that first reply was a typo.

He is up all night peeing but it might be easier for him to take them at bedtime with no food.

[Hidden]

When I started Zytiga (4x250mg per day), I was taking it in the evening before bedtime, but I was getting pretty severe leg cramps in my calves, and less so in thighs (while "sleeping"). Finally decided to take it first thing in the morning when I was active so I get the drug out of my system as soon as possible. No longer have any muscle cramps/spasms. I take it with my morning coffee....

I see you headed to Minnesota.... I am going there tomorrow for three weeks to see family.