PSMA PET-CT in patients with high-risk prostate cancer before curative-intent surgery or radiotherapy ((proPSMA): a RCT study.

[tango65]

"PSMA PET-CT is a suitable replacement for conventional imaging, providing superior accuracy, to the combined findings of CT and bone scanning."

thelancet.com/journals/lanc...

[cesces]

Hmmm

They don't appear to explain who they confirmed the accuracy of the two legs of the trial.

Psma just plain misses some non-pmsa cancers. Seems risky to rely on the test to catch those.

[Schwah in reply to cesces]

Why do you say that the PSMA scan Mrs. non-PSMA cancers.? When I had my PSMA scanned at UCLA, the head radiologist there (Dr Czerian) said that their scan also included conventional pet scan that should catch non-PSMA Avett cancer. Do you disagree ?

Schwah

[cesces in reply to Schwah]

Well it sounds like they did 2scans.

Tall Allen is the expert on this. He recommends another type of complimentary scan, but I don't remember it's name.

[immunity1 in reply to cesces]

I only have read the abstract. In this study incorporating a collection of patients at different sites thePSMA PETscan-CT was more accurate (includes sensitivity and specificity) than conventional CT scan plus a bone scan (using a gamma camera presumably after radioactive infusion of technetium). The latter is the SOC for many Radiation Oncologists. The paper does not discuss the use of FDG PET scan that Hofman and others like to use, as a complement to the PSMA PET in order to better manage future treatment.

Having had both types of diagnostic imaging carried out on me, twice, I agree with their findings.

[marnieg46]

Hi tango65. In addition to the article in The Lancet you might find the related video from urotoday (see link below) of interest.

Doctors Murphy and Hofman point out that it is fairly well established that men with high -risk localised prostate cancer are at an even higher risk of biochemical occurrence or persistence following initial treatment and that one of the reasons is that standard conventional imaging CT and bone scan fail to identify the true state of disease in these men. Two additional benefits of PSMA PET-CT noted are that the actual exposure to radiation is half that of current scanning of CT and bone scan and furthermore there is a significant cost benefit.

Regards, Marnieg.

urotoday.com/center-of-exce...