Zytiga and diabetes

[longleaf]

My husband has been started on zytiga for a month. His psa dropped from 3.5 to .77 so that was hopeful. He has been on lupron since May and underwent 6 treatments of docetaxal ending in September. His psa dropped to 1 then rose to 2.9 then 3.5. We’re very happy to see a good response on the zytiga. However his glucose was 162. The dr said we’d get another reading before diagnosing with diabetes. If he is diagnosed with diabetes what are his options?

[LearnAll]

Increased blood pressure and increased blood sugar are two common side effects of zytiga.

Dietary changes and physical activity with weght loss can reduce these side effects. Sometimes, meds may have to used to control blood sugar.

[Jimhoy]

LL

After being dx’ed with aPC, I learned a ton of info including drug names, side effects, symptoms, etc.... ADT symptoms have mostly moved on with my vacation except my mind!!! So there is a med that works both for PC and A1c but I can’t recall its name!!! Others will kick in the name I’m sure!!! Best of luck.

Jim C

[LearnAll in reply to Jimhoy]

Well..That medicine which lowers HbA1C and slows PCa growth is called Metformin....the supplement version of it is called Berberine.

[Jimhoy in reply to LearnAll]

What he said!!!!

Jc

[Kaliber]

It’s the same with Lupron Xtandi. My bg used to be 90 something in the mornings and could go up to 150 an hour after evening meals. My A1C low.

Now, after Lupron Xtandi my low bg happens around 5 in the evening at about 125 - 130 and climbs to 180 plus mornings. Higher and reversed of what it used to be. My GP has diagnosed it as “ drug induced diabetes “ . Still .... oddly my A1C is only 6.7 . I did start taking 250mg of metformin mornings just in case.

Shows you that your bg can look high daily but your A1C , the more important measure, can still look respectable. I’d wait and get that A1C reading to make decisions. Close consultation with your GP is always your best advice. Home A1C kits are as commonly available as bg kits if you want to watch it yourself.

🌸🦋🌻🌼😁

[Tall_Allen]

Zytiga may cause hyperglycemia. You can try cutting back on the dose or taking low-dose metformin with it.

Prednisone should not be a culprit at the dose he is taking (10 mg/day?), but he can try cutting back to 5 mg/day. It should be taken with meals. Peak blood glucose is 4 hours afterwards, so he should time his blood test when it is not paeking from the prednisone.