Hi
Been taking Zitiga, prednisalone, 3 monthly Prostap injections for about 18 months. Last couple of months been getting ectopic heartbeats and a few a fib results. Could this be the Zytiga has anyone experienced similar. psa seems ok steady 0.26 ish.
AF is listed as one of the side effects of Zytiga, The incidence of arrhythmias was 7.2% in patients taking Zytiga plus prednisone vs 4,6 % in patients taking placebo plus prednisone.
Since hypokalemia is a known complication of Zytiga treatment and hypokalemia could cause arrhythmias, you should have your electrolytes checked.
Solid info. Hope all is well in tangoville...
Fish
All well. Surviving and with the barbarians at the gates of the villa.
Hopefully not too close to the gates....wish the barbarians would run into a virus loaded with chemotherapeutics or radiation laden or something that would result in total genocide of the barbarians....and then....we could all resume normal lives and this would just be like a bad dream.....
Fish
Thanks.
Your welcome....I believe I made the woman unhappy on the liver post yesterday....perhaps she was bothered by my wishes for your good health coming before hers....we reply to people and one never knows how it will be taken. Keep up the good work...and fight on....with 290 trials, I feel we are due some breakthroughs.... Take care, brother....
Fish
Take care, best of luck with your treatment. Let's see if there will be good clinical trials in our future.
Consider getting on a low dose beta blocker to help stay in sinus rhythm if your blood pressure is slightly elevated or even normal....see below:
ncbi.nlm.nih.gov/pubmed/221...
Zytiga is known to cause blood pressure elevation--I would have your MD consider metoprolol 12.5 mg bid (2x/day) to start....
Good luck,
Don Pescado
Hi thanks for your reply. Had high bp for years increased bisoprolol to 10mg will ask cardiologist about metoprolol
If you are already on bisoprolol, then I am not sure you will get any more "bang for the buck" with metoprolol... your Cardiologist could raise the dose, or look at adding a rate related calcium channel blocker like Cardizem/diltiazem to your regimen or if you have a history of CHF(Congestive Heart Failure) then maybe adding Digoxin might make sense. The Cardiologist can guide you--just a few suggestions....
Don Pescado
Thanks for that, love this place everyone knows way more than me.
So what has your psa trajectory looked like over 18 months.
Did you get a prostatectomy or radiation treatment... And how long ago was that?
Hi metastatic when diagnose T3 11.2 psa gleason 9 Zitiga reduced fairly quickly averages 0.25/.27. diagnosed 18 months ago after gp treated me for 3 years for BHP !
You should ask your oncologist about taking a vacation from treatment and see how your psa responds.
If it pops up, then levels off, maybe can leave it alone for a while.
The more you pound away at it, the more likely and or sooner you may generate castrate resistant strains of the cancer.
If you still have your prostate, you will always have some level of psa. It is never going to be 0. You have prostate cells, and those cells will always generate psa.
If you are having episodes of paroxysmal AF (duration less than 7 days) you could consult with your doctor about adding Flecainide and/or a new oral anticoagulant (Xarelto, apixaban etc). The risk of thromboembolism during atrial fibrillation could be calculated using the CHADs score system:
clincalc.com/Cardiology/Str...
A score of 2 or higher indicates high risk and anti-coagulation is recommended.
The portable Kardia monitor is useful to monitor AF. It works with the cell phones. It does an automatic analysis of the ECGs and indicates the presence or absence of AF.
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