Zytiga

[Fight11]

I’m very concerned!! My husband most recently had a bone scan. He has been on Zytiga since Sept. As I had mentioned his psa was 13.3 went up a point to 14.6 then back down to to 13.7. His bone scan revealed a uptick in a couple new spots and more in the spots he had already. I spoke with his Oncologist and asked him what the plan is now? He said he didn’t feel as though the uptick in the bones was enough to change his med. I told him I’m concerned. I let a few messages with the Oncologist in Boston however I’ve yet to hear from them. I’m nervous the Zytiga is not doing it’s job obviously and no med change. The local Oncologist whom I spoke with said he is stable. How can he be stable if there are more areas on the bone scan?

[Tall_Allen]

Sorry - that's too small to read. What does it say?

[Fight11 in reply to Tall_Allen]

It says. Comparison 10/23/20 Focal intense uptake at the manubrium and right glenoid similar to prior exam.Developing focal moderate to intense activity within the inferior aspect of the left scapular body and mild focal uptake to the let 7th 8th and 10th ribs. Moderate to intense uptake within the iliac bones greater on left than right and mild uptake in the thoracombular by each kidney and excretion into the urinary bladder.

Impression

Developing uptake within the left scapular body and left ribs in keeping with modest progression of disease. 😩😩 what do you think

[Tall_Allen in reply to Fight11]

I think it's time to change therapies.

[Fight11 in reply to Tall_Allen]

I do to the local Oncologist doesn’t . I called his top notch Oncologist. I hope she calls back tried 5 times

[carbide in reply to Tall_Allen]

I had same problem.Just scroll down.

Thx

[Tall_Allen in reply to carbide]

Scroll down to what?

[carbide in reply to Tall_Allen]

Worked for me after two trys.Sorry. 👍

[tango65]

You could request to change prednisone for dexamethasone. It could extend the efficacy of Zytiga

pubmed.ncbi.nlm.nih.gov/300...

[Fight11 in reply to tango65]

It sure exactly what that means

[tango65 in reply to Fight11]

He is taking zytiga plus prednisone. Discuss changing prednisone for dexamethasone 0.5 mg/day. It could extend the efficacy of zytiga for a while.

[Faith1111]

Hi, I am no expert but it sounds like it’s time to find something else. If you are near Boston, my brother sees Dr. Beltran at Dana Farber. Bob failed Zytiga after a few short months. He is now in a clinical trial at Yale New Haven. ARV 110 It actually degrades the AR receptor. His PSA dropped from 15 to 1.7 in four weeks. We are waiting for the latest PSA results and he will be scanned in two weeks to get a better picture. Hoping to report back here some good results. Something you may want to look into. Also, has your husband been checked for mutations?

[Fight11 in reply to Faith1111]

Yes he has the cdk12 mutation. He too sees Dr Beltran waiting on a call

[Hidden in reply to Faith1111]

Hi Faith:How long has your husband had PC?

Thanks

[Faith1111 in reply to Hidden]

Diagnosed Oct 2018. Stage four at diagnosis Gleason 8. Several Mets. He is my youngest brother at 57.

[Hidden in reply to Faith1111]

Thanks