Zytiga

[Fight11]

My husband been on Zytiga about 5 months his psa was coming down very slow last psa was 13.7 it’s now 14.5 does this means the med stopped working already? Is this something I should be concerned about? Can you have small fluctuations In a psa

[dockam]

Yes, that's a possibility. But, MO will probably want a trend of rising PSAs before possibly switching out the med. Maybe also a scan eg Axumin. I started Abiraterone last Jan and had a slow drop from 10.2 and over several months only got to 4.1.

Then it started going up and at one point 5.1 to 9.2 in a month

Got on Xtandi only 2 months ago and PSA still rose 😭

Gonna do a rechallenge with Taxotere

Had 15 in 2015 and a PSA nadir of 0.1 in the Summer of 2017.

This was published last September:

prostatecancer.net/living/c...

My best to you and hubby

Fight on

Randy

[Gearhead in reply to dockam]

"started Abiraterone last Jan" "Got on Zytiga only 2 months ago" Zytiga is abiraterone, so I'm little confused.

[Chask in reply to Gearhead]

I agree, that is a little confusing. However my experience has shown a few ups and downs until a very steady rise which indicated “failure”. These are my readings from just before I started Abiraterone...

07/18 .46

07/18 Abiraterone/Prednisone started

08/18 .86

09/18. .81

10/18. .76

11/18. .83

01/19. .80

02/19. 1.20

04/19. .8

06/19. .95

08/19. 1.2

10/19. 1.4

11/19. 1.1

01/20. 1.4

03/20. 2.1

05/20. 2.3

08/20. 3.1

09/20. 4.0

11/20. 10.0

It was after the 9/20 reading that I switched from Prednisone to Dexamethasone. Am back now on Prednisone and about to start the next level of treatment. Because I am Oligometastatic (2 bone mets) will try SBRT - while continuing Zoladex and Abiraterone.

[Engraver68 in reply to Chask]

Hi

I have had a similar trend with Zytiga + pred and I had SABR treatment to be met in September. My PSA has halved from 2.5 - 1.2 in four months while staying on systemic treatment. It seems to work if you are low burden cancer and oligometastic

Good luck!👍

[Chask in reply to Engraver68]

Good for you! I am hoping for a similar result, and hopefully an ongoing reduction in PSA.

[dhccpa in reply to Gearhead]

I had same question.

[dockam in reply to Gearhead]

Oops. meant Xtandi

[dhccpa]

Is he taking with or without food?

[Fight11 in reply to dhccpa]

Without

[Magnus1964]

It is a small increase and may be due to irritations or inflammation. Look for trends. If the next two readings are higher, then he is failing zytiga and it's time to move to another drug.

[Fight11 in reply to Magnus1964]

His Oncologist has him come every 6 weeks to check his psa. Do you think that’s to long of a gap? Should it be sooner seen as though he is castrate resistant?

[Magnus1964 in reply to Fight11]

That could be increased to once pre month.

[Ldtyson]

The Zytiga and prednisone really bothered me. I had horrible headaches. Dr. Finally put me on Erleada with no prednisone and I use a half dose and I'm now fine. .01 psa. The prednisone caused me to constantly eat. They claim this was all in my head. Right.