Prolia vs Xgeva ? MO wants to give me Xgeva shot every four weeks whereas Prolia is every six months. Both has the same effect?

[Melaine50]

On Lupron , Zytiga and Prednisone- MO wants me to go on Xgeva next week Because of bone Met. My psa has decreased from 500 to 2.2 .

[tango65]

They are the same drug (denosumab). Prolia is used to treat osteoporosis in patients with high risk for fractures. Xgeva is used to reduce the incidence of skeletal events (fractures, pain) in patients with bone metastases.

xgeva.com/about-xgeva/clini...

[Melaine50 in reply to tango65]

Thanks . Dr. recommending XGEVA based on his patients experiences with the drug and also because of my bone Mets.

[tango65 in reply to Melaine50]

Best of luck!!

[Tall_Allen]

Think of prolia as Xgeva Lite. With a metastasis and danger of fracture or spinal compression, you'll want Xgeva. Consider adding Celebrex.

[Melaine50 in reply to Tall_Allen]

Good description of the two. I used to take Celebrex as off label drug but forgot to ask doctor about Celebrex. Will do so in April

[Hidden]

Great drop in psa. I started prolia due to osteopenia from adt use . Our bones take a heavy hit in all of this . Good luck with Xgeva..I pray that this med helps us both.. good luck 🍀

[Cheerr in reply to Hidden]

How did you decide you needed it? Did you do a DEXA bone scan ?

Our MO says once in 6 months or a year is enough for dad now. But I want to make sure we take it more often if needed?

[Hidden in reply to Cheerr]

I’m on a test drug and test annually for bone loss, a dexa scan showed I’m in osteopenia after five years of adt . lost 5% this year , 15 % last year . If I keep it up I felt I’ll be slug like in few more years . Just trying to hang on . Cheers to you in this adventure !

[Melaine50 in reply to Hidden]

After consulting with Dr. today I will be going with Exgeva. All the best.

[Hidden in reply to Melaine50]

May it save your bones.😎

[leo2634]

I was given Xgeva for around 10 months until it started really lowering my Calcium level which by the way can really do a number on you. I have been on a Xgeva vacation now for 3 months and Doc has doubled my Calcium supplement so now level is back to normal range. I will probably resume Xgeva injection on my next visit around the end of March. Leo

[Hidden in reply to leo2634]

Calcium so important now !😎

[Melaine50 in reply to leo2634]

It’s good to see some flexibility in your Exgeva treatment. I am taking calcium pills plus calcium rich foods. Best

[Hidden in reply to leo2634]

How much calcium are you taking ?

[leo2634 in reply to Hidden]

2000 units in the morning and 2000 at night

I go back to the doctor on the 24th so my guess is I'll be back to the 2000 once a day beings my levels are normal again

It's been four months since last Xgeva injection

[Melaine50 in reply to Hidden]

1500 mg

[Melaine50 in reply to Hidden]

1500

[Break60]

I was on xgeva monthly after bone mets then switched to quarterly because my annual bone density scans are good. See my profile.

[Hidden in reply to Break60]

👍

[Melaine50 in reply to Break60]

That’s good news! And being able to switch to quarterly schedule From monthly.

[noirhole]

You can get a 3 month xgeva injection. I think the hospital charges my insurance about 11k. Sure would like to shop around for better drug prices. Need more competition.

[Melaine50 in reply to noirhole]

At least the three month injection cost is less than a monthly one? And more convenient .Was led to believe that there was only a monthly one. Agree on the lack of competition

[Break60 in reply to Melaine50]

I get the same dose quarterly that I had gotten monthly . So it’s a lower daily dose because I don’t need as much. So cost per day is obviously lower.

[Break60 in reply to noirhole]

That is preposterous! I buy my injection from Walgreens or CVS which costs me no more than $600 declining every three months . Insurance under Medicare part D pays the rest (around$1800) and my urologist injects it for $35!

[dmt1121]

I was on Xgeva for a few months and changed MO's. The new MO placed me on Prolia as a counter to osteoporosis because I only had one small met that had been treated on my left femur. She felt that Xgeva was too strong and had a history of a higher increased risk for certain types of fractures, including necrosis of the jaw than Prolia. She felt the benefits did not outway the risks of side effects in my case.

Essentially, I understand Xgeva to be for bone mets where it actually strengthens the areas where bone mets occur (as well as overall bone strengthening) and Prolia is for bone strengthening related to osteoporosis level risk for fracture and provides a lower risk for related side effects.

[Break60 in reply to dmt1121]

I think you’re right. When I first went on long term Lupron ( 13 MOs) my RO put me on prolia to mitigate osteoporosis. When I later had a bone met he suggested monthly xgeva which I was on for a couple years . My urologist suggested I drop down to quarterly after good bone density results. That’s where I am now with no mets and undetectable psa.

[Melaine50 in reply to Break60]

Congratulations on the outcome. Wish you continued success.

[Hidden in reply to Break60]

Hallelujah!

[Melaine50 in reply to dmt1121]

Thanks for the information. After a lengthy discussion with my MO today I am going with XGEVA because of my bone Mets.

[Hidden in reply to Melaine50]

May it serve you well!😎