Falling platelets

[Baddawg]

Gleason 9, stage 4 in 2011

Seeding, radiation, lupron, patch, trelstar, exteva, xtandi, more radiation, still on xtandi but over last 6 months PSA has been rapidly increasing, then provenge treatment but PSA doubled to 247.

Now platelets have been going downhill and had platelet infusion but platelets are down to 29! Onc says bone marrow is not making platelets, probably due to radiation!

Any advise or experience with this? Thanks!

[Baddawg]

Good info, thanks!

[tango65]

I wonder what is happening with the other blood cells. Do you have the results of a recent CBC?

[Baddawg in reply to tango65]

Yes, White And red are low, hemoglobin too. Absolute Lymps are very low.

[tango65 in reply to Baddawg]

This could be a diffuse bone marrow infiltration by the cancer since all the blood cell lines are affected and his PSA has been increasing rapidly reaching a high value. If his MO is not a hematologists, you could request a consultation with a hematologist.

[Hidden]

It could be bone marrow invasion from the cancer. How long ago was the radiation and how does the rest of the CBC look? I agree with Nalakrats about getting molecular testing as soon as possible to see if there are targeted treatments available.

[Baddawg in reply to Hidden]

Thanks, will discuss with my hematologists.

[Baddawg]

Thanks, will do!

[Baddawg]

Thanks for the info, much appreciated and helpful!